Notch1 and Notch3 instructively restrict bFGF-responsive multipotent neural progenitor cells to an astroglial fate.

abstract：:We recorded from single neurons in the hippocampus and entorhinal cortex (EC) of rats to investigate the role of these structures in navigation and memory representation. Our results revealed two novel phenomena: first, many cells in CA1 and the EC fired at significantly different rates when the animal was in the same...

journal_title：Neuron

authors： Frank LM,Brown EN,Wilson M

更新日期：2000-07-01 00:00:00

abstract：:Small conductance Ca(2+)-activated K(+) (SK) channels and voltage-gated A-type Kv4 channels shape dendritic excitatory postsynaptic potentials (EPSPs) in hippocampal CA1 pyramidal neurons. Synaptically evoked Ca(2+) influx through N-methyl-D-aspartate receptors (NMDARs) activates spine SK channels, reducing EPSPs and ...

journal_title：Neuron

authors： Wang K,Lin MT,Adelman JP,Maylie J

更新日期：2014-01-22 00:00:00

abstract：:We have examined the long-term effects of notochord ablation at chick stages 9-10 on formation of the floor plate and motor neurons. Although missing or reduced 2 days postablation, the floor plate and motor neurons were morphologically normal by 4 postoperative days. When isolated whole or ventral, but not lateral, n...

journal_title：Neuron

authors： Artinger KB,Bronner-Fraser M

更新日期：1993-12-01 00:00:00

abstract：:Trk tyrosine kinases are receptors for members of the neurotrophin family and are crucial for growth and survival of specific populations of neurons. Yet, the functions of neurotrophin-Trk signaling in postnatal development as well as maintenance and plasticity of the adult nervous system are less clear. We report her...

journal_title：Neuron

authors： Chen X,Ye H,Kuruvilla R,Ramanan N,Scangos KW,Zhang C,Johnson NM,England PM,Shokat KM,Ginty DD

更新日期：2005-04-07 00:00:00

abstract：:Commissural axons are attracted to the midline intermediate target by chemoattractants, but upon crossing the midline they switch off responsiveness to attractants and switch on responsiveness to midline repellents, which expel the axons from the midline and enable them to move on. Here we show that midline exit also ...

journal_title：Neuron

authors： Gore BB,Wong KG,Tessier-Lavigne M

更新日期：2008-02-28 00:00:00

abstract：:Inappropriate vocal expressions, e.g., vocal tics in Tourette syndrome, severely impact quality of life. Neural mechanisms underlying vocal tics remain unexplored because no established animal model representing the condition exists. We report that unilateral disinhibition of the nucleus accumbens (NAc) generates voca...

journal_title：Neuron

authors： McCairn KW,Nagai Y,Hori Y,Ninomiya T,Kikuchi E,Lee JY,Suhara T,Iriki A,Minamimoto T,Takada M,Isoda M,Matsumoto M

更新日期：2016-01-20 00:00:00

abstract：:We explored the relationship between regulation of the spine actin cytoskeleton, spine morphogenesis, and synapse formation by manipulating expression of the actin binding protein NrbI and its deletion mutants. In pyramidal neurons of cultured rat hippocampal slices, NrbI is concentrated in dendritic spines by binding...

journal_title：Neuron

authors： Zito K,Knott G,Shepherd GM,Shenolikar S,Svoboda K

更新日期：2004-10-14 00:00:00

abstract：:Proteolipid protein (PLP) is an integral membrane protein of CNS myelin. Mutations of the X chromosome-linked PLP gene cause glial cell death and myelin deficiency in jimpy mice and other neurological mutants. As part of an attempt to rescue these mutants by transgenic complementation, we generated normal mouse lines ...

journal_title：Neuron

authors： Readhead C,Schneider A,Griffiths I,Nave KA

更新日期：1994-03-01 00:00:00

abstract：:T-type calcium channels are essential contributors to the transmission of nociceptive signals in the primary afferent pain pathway. Here, we show that T-type calcium channels are ubiquitinated by WWP1, a plasma-membrane-associated ubiquitin ligase that binds to the intracellular domain III-IV linker region of the Cav3...

journal_title：Neuron

authors： García-Caballero A,Gadotti VM,Stemkowski P,Weiss N,Souza IA,Hodgkinson V,Bladen C,Chen L,Hamid J,Pizzoccaro A,Deage M,François A,Bourinet E,Zamponi GW

更新日期：2014-09-03 00:00:00

abstract：:A series of recent papers highlight a prominent role for ubiquitin in the formation and function of neural circuits. These new results focus attention on the molecular remodeling that occurs at various decision points in the life of growth cones and synapses. ...

journal_title：Neuron

authors： Murphey RK,Godenschwege TA

更新日期：2002-09-26 00:00:00

abstract：:Forty years ago, von Békésy demonstrated that the spatial source of an odorant is determined by comparing input across nostrils, but it is unknown how this comparison is effected in the brain. To address this, we delivered odorants to the left or right of the nose, and contrasted olfactory left versus right localizati...

journal_title：Neuron

authors： Porter J,Anand T,Johnson B,Khan RM,Sobel N

更新日期：2005-08-18 00:00:00

abstract：:Direction-selective ganglion cells (DSGCs) are tuned to motion in one direction. Starburst amacrine cells (SACs) are thought to mediate this direction selectivity through precise anatomical wiring to DSGCs. Nevertheless, we previously found that visual adaptation can reverse DSGCs's directional tuning, overcoming the ...

journal_title：Neuron

authors： Vlasits AL,Bos R,Morrie RD,Fortuny C,Flannery JG,Feller MB,Rivlin-Etzion M

更新日期：2014-09-03 00:00:00

abstract：:Using somatic cell nuclear transfer, Hazen et al. (2016) examined clonally expanded single neurons for mutations and found ∼100 mutations from a variety of classes. Post-mitotic mutations in individual neurons represent an exploratory direction for finding fundamental origins of neurodegeneration. ...

journal_title：Neuron

authors： Kosik KS

更新日期：2016-03-16 00:00:00

abstract：:The product of the Wnt-1 proto-oncogene is a secreted glycoprotein that is normally produced in regions of the embryonic neural tube. We show here that expression of mouse Wnt-1 cDNA in the rat PC12 pheochromocytoma cell line causes a dramatic conversion from a round to a flat cell morphology. In addition, PC12 cells ...

journal_title：Neuron

authors： Shackleford GM,Willert K,Wang J,Varmus HE

更新日期：1993-11-01 00:00:00

abstract：:The hippocampal CA2 subregion has a different anatomical connectivity pattern within the entorhino-hippocampal circuit than either the CA1 or CA3 subregion. Yet major differences in the neuronal activity patterns of CA2 compared with the other CA subregions have not been reported. We show that standard spatial and tem...

journal_title：Neuron

authors： Mankin EA,Diehl GW,Sparks FT,Leutgeb S,Leutgeb JK

更新日期：2015-01-07 00:00:00

abstract：:The mesolimbic system is known to play a role in self-administration of opioids and psychostimulants. Although morphine and cocaine act by separate cellular mechanisms initially, the present study describes a common change in synaptic regulation of dopamine cells in the ventral tegmental area 1 week after termination ...

journal_title：Neuron

authors： Bonci A,Williams JT

更新日期：1996-03-01 00:00:00

abstract：:Protrusive behavior of dendritic spines on developing neurons has been previously suggested to mediate the formation of new axodendritic synaptic contacts. A study by Zito et al. in this issue of Neuron links actin polymerization in dendritic spines with the motility that the spines exhibit and the synapses that they ...

journal_title：Neuron

authors： Dunaevsky A

更新日期：2004-10-14 00:00:00

abstract：:Postlingually deaf subjects learn the meaning of sounds after cochlear implantation by forming new associations between sounds and their sources. Implants generate coarse frequency responses, preventing place-coding fine enough to discriminate sounds with similar temporal characteristics, e.g., buck/duck. This limitat...

journal_title：Neuron

authors： Giraud AL,Price CJ,Graham JM,Truy E,Frackowiak RS

更新日期：2001-06-01 00:00:00

abstract：:Olfaction is a vitally important sense for all animals. There are striking similarities between species in the organization of the olfactory pathway, from the nature of the odorant receptor proteins, to perireceptor processes, to the organization of the olfactory CNS, through odor-guided behavior and memory. These com...

journal_title：Neuron

authors： Ache BW,Young JM

更新日期：2005-11-03 00:00:00

abstract：:Synaptic clustering of neurotransmitter receptors is crucial for efficient signal transduction and integration in neurons. PDZ domain-containing proteins such as PSD-95/SAP90 interact with the intracellular C termini of a variety of receptors and are thought to be important in the targeting and anchoring of receptors ...

journal_title：Neuron

authors： Xia J,Zhang X,Staudinger J,Huganir RL

更新日期：1999-01-01 00:00:00

abstract：:Alternative polyadenylation (APA) is increasingly recognized to regulate gene expression across different cell types, but obtaining APA maps from individual cell types typically requires prior purification, a stressful procedure that can itself alter cellular states. Here, we describe a new platform, cTag-PAPERCLIP, t...

journal_title：Neuron

authors： Hwang HW,Saito Y,Park CY,Blachère NE,Tajima Y,Fak JJ,Zucker-Scharff I,Darnell RB

更新日期：2017-09-13 00:00:00

abstract：:alpha-tectorin is an extracellular matrix molecule of the inner ear. Mice homozygous for a targeted deletion in a-tectorin have tectorial membranes that are detached from the cochlear epithelium and lack all noncollagenous matrix, but the architecture of the organ of Corti is otherwise normal. The basilar membranes of...

journal_title：Neuron

authors： Legan PK,Lukashkina VA,Goodyear RJ,Kössi M,Russell IJ,Richardson GP

更新日期：2000-10-01 00:00:00

abstract：:Functionally distinct types of neurons develop in stereotypical positions in the vertebrate spinal cord. The mechanisms that generate this diversity have been well studied in the ventral and intermediate regions of the spinal cord, while dorsal cells have received less attention. In this issue of Neuron, two papers fo...

journal_title：Neuron

authors： Matise M

更新日期：2002-05-16 00:00:00

abstract：:Plus end tracking proteins (+TIPS) bind to microtubules. Results reported by Lee et al. and Zhou et al. in this issue of Neuron demonstrate that, via intracellular pathways signaling to +TIPs, microtubules can be a direct target of guidance cues in steering growth cones and regulating axon elongation. ...

journal_title：Neuron

authors： Kalil K,Dent EW

更新日期：2004-06-24 00:00:00

abstract：:To assess the role of exocytotic release in signaling by monoamines, we have disrupted the neuronal vesicular monoamine transporter 2 (VMAT2) gene. VMAT2-/- mice move little, feed poorly, and die within a few days after birth. Monoamine cell groups and their projections are indistinguishable from those of wild-type li...

journal_title：Neuron

authors： Fon EA,Pothos EN,Sun BC,Killeen N,Sulzer D,Edwards RH

更新日期：1997-12-01 00:00:00

abstract：:Voltage-gated ion channels generate electrical signals in species from bacteria to man. Their voltage-sensing modules are responsible for initiation of action potentials and graded membrane potential changes in response to synaptic input and other physiological stimuli. Extensive structure-function studies, structure ...

journal_title：Neuron

authors： Catterall WA

更新日期：2010-09-23 00:00:00

abstract：:Currently, there are no medications that effectively treat the core symptoms of Autism Spectrum Disorder (ASD). We recently found that the bacterial species Lactobacillus (L.) reuteri reverses social deficits in maternal high-fat-diet offspring. However, whether the effect of L. reuteri on social behavior is generaliz...

journal_title：Neuron

authors： Sgritta M,Dooling SW,Buffington SA,Momin EN,Francis MB,Britton RA,Costa-Mattioli M

更新日期：2019-01-16 00:00:00

abstract：:Rhythmic spontaneous electrical activity occurs in many parts of the developing nervous system, where it plays essential roles in the refinement of neural connections. By blocking or slowing this bursting activity, via in ovo drug applications at precise developmental periods, we show that such activity is also requir...

journal_title：Neuron

authors： Hanson MG,Landmesser LT

更新日期：2004-09-02 00:00:00

abstract：:bHLH and LIM-HD transcription factors were originally thought to act at different stages of neurogenesis: bHLHs as neuronal "inducers" and LIM-HDs as postmitotic subtype determinants. These distinctions are becoming blurred, and a current study by Lee and Pfaff in this issue of Neuron shows that interaction between th...

journal_title：Neuron

authors： Allan DW,Thor S

更新日期：2003-06-05 00:00:00

abstract：:We have examined the role of presynaptic residual calcium in maintaining long-term changes in synaptic efficacy observed at mossy fiber synapses between hippocampal dentate granule cells and CA3 pyramidal cells. Calcium concentrations in individual mossy fiber terminals in hippocampal slice were optically measured wit...

journal_title：Neuron

authors： Regehr WG,Tank DW

更新日期：1991-09-01 00:00:00