Abstract:
:To assess the role of exocytotic release in signaling by monoamines, we have disrupted the neuronal vesicular monoamine transporter 2 (VMAT2) gene. VMAT2-/- mice move little, feed poorly, and die within a few days after birth. Monoamine cell groups and their projections are indistinguishable from those of wild-type littermates, but the brains of mutant mice show a drastic reduction in monoamines. Using midbrain cultures from the mutant animals, amphetamine but not depolarization induces dopamine release. In vivo, amphetamine increases movement, promotes feeding, and prolongs the survival of VMAT2-/- animals, indicating that precise, temporally regulated exocytotic release of monoamine is not required for certain complex behaviors. In addition, the brains of VMAT2 heterozygotes contain substantially lower monoamine levels than those of wild-type littermates, and depolarization induces less dopamine release from heterozygous than from wild-type cultures, suggesting that VMAT2 expression regulates monoamine storage and release.
journal_name
Neuronjournal_title
Neuronauthors
Fon EA,Pothos EN,Sun BC,Killeen N,Sulzer D,Edwards RHdoi
10.1016/s0896-6273(00)80418-3subject
Has Abstractpub_date
1997-12-01 00:00:00pages
1271-83issue
6eissn
0896-6273issn
1097-4199pii
S0896-6273(00)80418-3journal_volume
19pub_type
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