Abstract:
:The replay of previously stored memories during hippocampal sharp wave ripples (SWRs) is thought to support both memory retrieval and consolidation in distributed hippocampal-neocortical circuits. Replay events consist of precisely timed sequences of spikes from CA3 and CA1 neurons that are coordinated both within and across hemispheres. The mechanism of this coordination is not understood. Here, we show that during SWRs in both awake and quiescent states there are transient increases in slow gamma (20-50 Hz) power and synchrony across dorsal CA3 and CA1 networks of both hemispheres. These gamma oscillations entrain CA3 and CA1 spiking. Moreover, during awake SWRs, higher levels of slow gamma synchrony are predictive of higher quality replay of past experiences. Our results indicate that CA3-CA1 gamma synchronization is a central component of awake memory replay and suggest that transient gamma synchronization serves as a clocking mechanism to enable coordinated memory reactivation across the hippocampal network.
journal_name
Neuronjournal_title
Neuronauthors
Carr MF,Karlsson MP,Frank LMdoi
10.1016/j.neuron.2012.06.014subject
Has Abstractpub_date
2012-08-23 00:00:00pages
700-13issue
4eissn
0896-6273issn
1097-4199pii
S0896-6273(12)00576-4journal_volume
75pub_type
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