Abstract：
:Sensory input reaching the brain from bilateral and offset channels is nonetheless perceived as unified. This unity could be explained by simultaneous projections to both hemispheres, or inter-hemispheric information transfer between sensory cortical maps. Odor input, however, is not topographically organized, nor does it project bilaterally, making olfactory perceptual unity enigmatic. Here we report a circuit that interconnects mirror-symmetric isofunctional mitral/tufted cells between the mouse olfactory bulbs. Connected neurons respond to similar odors from ipsi- and contra-nostrils, whereas unconnected neurons do not respond to odors from the contralateral nostril. This connectivity is likely mediated through a one-to-one mapping from mitral/tufted neurons to the ipsilateral anterior olfactory nucleus pars externa, which activates the mirror-symmetric isofunctional mitral/tufted neurons glutamatergically. This circuit enables sharing of odor information across hemispheres in the absence of a cortical topographical organization, suggesting that olfactory glomerular maps are the equivalent of cortical sensory maps found in other senses.
journal_name
Neuronjournal_title
Neuronauthors
Grobman M,Dalal T,Lavian H,Shmuel R,Belelovsky K,Xu F,Korngreen A,Haddad Rdoi
10.1016/j.neuron.2018.07.012subject
Has Abstractpub_date
2018-08-22 00:00:00pages
800-813.e6issue
4eissn
0896-6273issn
1097-4199pii
S0896-6273(18)30586-5journal_volume
99pub_type
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