Synaptic homeostasis on the fast track.

abstract：:Several plasma membrane chloride channels are well characterized, but much less is known about the molecular identity and function of intracellular Cl- channels. ClC-3 is thought to mediate swelling-activated plasma membrane currents, but we now show that this broadly expressed chloride channel is present in endosomal...

journal_title：Neuron

authors： Stobrawa SM,Breiderhoff T,Takamori S,Engel D,Schweizer M,Zdebik AA,Bösl MR,Ruether K,Jahn H,Draguhn A,Jahn R,Jentsch TJ

更新日期：2001-01-01 00:00:00

abstract：:Hippocampal replays have been demonstrated to play a crucial role in memory. Chains of ripples (ripple bursts) in CA1 have been reported to co-occur with long-range place cell sequence replays during the quiet awake state, but roles of neural inputs to CA1 in ripple bursts and replays are unknown. Here we show that ri...

journal_title：Neuron

authors： Yamamoto J,Tonegawa S

更新日期：2017-09-27 00:00:00

abstract：:Spontaneous activity patterns in the developing retina appear important for the functional organization of the visual system. We show here that an absence of early retinal waves in mice lacking the beta2 subunit of the nicotinic acetylcholine receptor (nAChR) is associated with both gain and loss of functional organiz...

journal_title：Neuron

authors： Grubb MS,Rossi FM,Changeux JP,Thompson ID

更新日期：2003-12-18 00:00:00

abstract：:Relatively little is known about the neural circuitry underlying sex-specific behaviors. We have expressed the feminizing gene transformer in genetically defined subregions of the brain of male Drosophila, and in particular within different domains of the mushroom bodies. Mushroom bodies are phylogenetically conserved...

journal_title：Neuron

authors： O'Dell KM,Armstrong JD,Yang MY,Kaiser K

更新日期：1995-07-01 00:00:00

abstract：:Cytokines are pleotrophic proteins that coordinate the host response to infection as well as mediate normal, ongoing signaling between cells of nonimmune tissues, including the nervous system. As a consequence of this dual role, cytokines induced in response to maternal infection or prenatal hypoxia can profoundly imp...

journal_title：Neuron

authors： Deverman BE,Patterson PH

更新日期：2009-10-15 00:00:00

abstract：:We constructed a recombinant baculovirus, A. californica nuclear polyhedrosis virus, containing the Drosophila Shaker H4 K+ channel cDNA under control of the polyhedrin promoter. When infected with this recombinant baculovirus, the cell line Sf9, derived from the army-worm caterpillar S. frugiperda, expresses fully fu...

journal_title：Neuron

authors： Klaiber K,Williams N,Roberts TM,Papazian DM,Jan LY,Miller C

更新日期：1990-08-01 00:00:00

abstract：:Primates with long-standing therapeutic amputations of a limb at a young age were used to investigate the possibility that deefferented motor nerves sprout to new muscle targets. Injections of anatomical tracers into the muscles proximal to the amputated stump labeled a larger extent of motoneurons than matched inject...

journal_title：Neuron

authors： Wu CW,Kaas JH

更新日期：2000-12-01 00:00:00

abstract：:The forebrain is one of most complex cellular structures known. Two phenomena that enable this complexity are tangential migrations that mix neurons from distinct progenitor fields, and axon guidance across intervening, noninnervated fields. A new paper in Cell by López-Bendito et al. has discovered the convergence of...

journal_title：Neuron

authors： Maroof AM,Anderson SA

更新日期：2006-04-20 00:00:00

abstract：:Elevation of cAMP can overcome myelin inhibitors to encourage regeneration of the CNS. We show that a consequence of elevated cAMP is the synthesis of polyamines, resulting from an up-regulation of Arginase I, a key enzyme in their synthesis. Inhibiting polyamine synthesis blocks the cAMP effect on regeneration. Eithe...

journal_title：Neuron

authors： Cai D,Deng K,Mellado W,Lee J,Ratan RR,Filbin MT

更新日期：2002-08-15 00:00:00

abstract：:Locomotion is controlled by spinal networks that generate rhythm and coordinate left-right and flexor-extensor patterning. Defined populations of spinal interneurons have been linked to patterning circuits; however, neurons comprising the rhythm-generating kernel have remained elusive. Here, we identify an ipsilateral...

journal_title：Neuron

authors： Dougherty KJ,Zagoraiou L,Satoh D,Rozani I,Doobar S,Arber S,Jessell TM,Kiehn O

更新日期：2013-11-20 00:00:00

abstract：:Phosphorylation of brain Na+ channels by protein kinase C (PKC) decreases peak Na+ current and slows macroscopic inactivation, but receptor-activated modulation of Na+ currents via the PKC pathway has not been demonstrated. We have examined modulation of Na+ channels by activation of muscarinic receptors in acutely-is...

journal_title：Neuron

authors： Cantrell AR,Ma JY,Scheuer T,Catterall WA

更新日期：1996-05-01 00:00:00

abstract：:Pathological aggregation of the microtubule-associated protein tau is a common feature of many neurodegenerative diseases. Although tau aggregation is associated with abnormal tau phosphorylation, the role of phosphorylation in the initiation of neurodegeneration has been unclear. Now, several animal models and data f...

journal_title：Neuron

authors： Geschwind DH

更新日期：2003-10-30 00:00:00

abstract：:Parkinson's disease (PD) is a neurodegenerative disease characterized by the selective demise of specific neuronal populations leading to impairment of motor functions. Recent genetic studies have uncovered several genes involved in inherited forms of the disease. These gene products are implicated in the biochemical ...

journal_title：Neuron

authors： Giasson BI,Lee VM

更新日期：2001-09-27 00:00:00

abstract：VIDEO ABSTRACT:The precise connectivity of inputs and outputs is critical for cerebral cortex function; however, the cellular mechanisms that establish these connections are poorly understood. Here, we show that the secreted molecule Sonic Hedgehog (Shh) is involved in synapse formation of a specific cortical circuit. ...

journal_title：Neuron

authors： Harwell CC,Parker PR,Gee SM,Okada A,McConnell SK,Kreitzer AC,Kriegstein AR

更新日期：2012-03-22 00:00:00

abstract：:Acquisition of new learning is challenged by the phenomenon of proactive interference (PI), which occurs when previous learning disrupts later learning. Whereas human neuroimaging studies have focused on the cortical contributions to interference resolution, animal studies demonstrate that efficient resolution of PI d...

journal_title：Neuron

authors： De Rosa E,Desmond JE,Anderson AK,Pfefferbaum A,Sullivan EV

更新日期：2004-03-04 00:00:00

abstract：:Dendritic structure critically determines the electrical properties of neurons and, thereby, defines the fundamental process of input-to-output conversion. The diversity of dendritic architectures enables neurons to fulfill their specialized circuit functions during cognitive processes. It is known that this dendritic...

journal_title：Neuron

authors： Šišková Z,Justus D,Kaneko H,Friedrichs D,Henneberg N,Beutel T,Pitsch J,Schoch S,Becker A,von der Kammer H,Remy S

更新日期：2014-12-03 00:00:00

abstract：:The role of the target cell in neurotrophin-induced modifications of glutamatergic synaptic transmission was examined in cultured hippocampal neurons. Brain-derived neurotrophic factor (BDNF) induced rapid and persistent potentiation of evoked glutamate release when the postsynaptic neuron was glutamatergic, or excita...

journal_title：Neuron

authors： Schinder AF,Berninger B,Poo M

更新日期：2000-01-01 00:00:00

abstract：:We generated transgenic mice that specifically express foreign genes in myelinating Schwann cells. A 1.1 kb segment of 5' flanking sequence from the rat P0 gene was used to drive expression of the genes encoding human growth hormone (hGH) and bacterial diphtheria toxin A chain (DT-A). The P0-hGH mice expressed hGH in ...

journal_title：Neuron

authors： Messing A,Behringer RR,Hammang JP,Palmiter RD,Brinster RL,Lemke G

更新日期：1992-03-01 00:00:00

abstract：:Light-evoked responses of all three major classes of retinal ganglion cells (RGCs) are mediated by NMDA receptors (NMDARs) and AMPA receptors (AMPARs). Although synaptic activity at RGC synapses is highly dynamic, synaptic plasticity has not been observed in adult RGCs. Here, using patch-clamp recordings in dark-adapt...

journal_title：Neuron

authors： Jones RS,Carroll RC,Nawy S

更新日期：2012-08-09 00:00:00

abstract：:Abl is an axonal tyrosine kinase that has yet to be clearly linked to a receptor; Notch is a receptor for which the signaling pathway remains incompletely understood. We show here that Notch and abl mutations interact synergistically to produce synthetic lethality and defects in axon extension. Surprisingly, we cannot...

journal_title：Neuron

authors： Giniger E

更新日期：1998-04-01 00:00:00

abstract：:FLRTs are broadly expressed proteins with the unique property of acting as homophilic cell adhesion molecules and as heterophilic repulsive ligands of Unc5/Netrin receptors. How these functions direct cell behavior and the molecular mechanisms involved remain largely unclear. Here we use X-ray crystallography to revea...

journal_title：Neuron

authors： Seiradake E,del Toro D,Nagel D,Cop F,Härtl R,Ruff T,Seyit-Bremer G,Harlos K,Border EC,Acker-Palmer A,Jones EY,Klein R

更新日期：2014-10-22 00:00:00

abstract：:Neuronal activity-dependent processes are believed to mediate the formation of synaptic connections during neocortical development, but the underlying intracellular mechanisms are not known. In the visual system, altering the pattern of visually driven neuronal activity by monocular deprivation induces cortical synapt...

journal_title：Neuron

authors： Pham TA,Impey S,Storm DR,Stryker MP

更新日期：1999-01-01 00:00:00

abstract：:How does a visual search goal modulate the activity of neurons encoding different visual features (e.g., color, direction of motion)? Previous research suggests that goal-driven attention enhances the gain of neurons representing the target's visual features. Here, we present mathematical and behavioral evidence that ...

journal_title：Neuron

authors： Navalpakkam V,Itti L

更新日期：2007-02-15 00:00:00

abstract：:For each environment a rodent has explored, its hippocampus contains a map consisting of a unique subset of neurons, called place cells, that have spatially tuned spiking there, with the remaining neurons being essentially silent. Using whole-cell recording in freely moving rats exploring a novel maze, we observed dif...

journal_title：Neuron

authors： Epsztein J,Brecht M,Lee AK

更新日期：2011-04-14 00:00:00

abstract：:Advances in defining mechanisms of cortical development have been paralleled in recent years by an intense interest in translating these findings into greater insight of both childhood- and adult-onset cognitive and mental health disorders of developmental etiology. Successful integration of basic and clinical finding...

journal_title：Neuron

authors： Levitt P

更新日期：2005-05-05 00:00:00

abstract：:The brain mechanisms underlying visual object categorization remain unclear. In this issue of Neuron, Minamimoto and colleagues introduce a novel task that associates each category with a different incentive value, and they demonstrate that it can be learned within a single session even after ablation of the lateral p...

journal_title：Neuron

authors： Buckley MJ,Sigala N

更新日期：2010-05-27 00:00:00

abstract：:At each of the brain's vast number of synapses, the presynaptic nerve terminal, synaptic cleft, and postsynaptic specialization form a transcellular unit to enable efficient transmission of information between neurons. While we know much about the molecular machinery within each compartment, we are only beginning to u...

journal_title：Neuron

authors： Biederer T,Kaeser PS,Blanpied TA

更新日期：2017-11-01 00:00:00

abstract：:The product of the Wnt-1 proto-oncogene is a secreted glycoprotein that is normally produced in regions of the embryonic neural tube. We show here that expression of mouse Wnt-1 cDNA in the rat PC12 pheochromocytoma cell line causes a dramatic conversion from a round to a flat cell morphology. In addition, PC12 cells ...

journal_title：Neuron

authors： Shackleford GM,Willert K,Wang J,Varmus HE

更新日期：1993-11-01 00:00:00

abstract：:A study by Zhang et al. in this issue of Neuron reveals a novel mechanism of control of vestibular motor functions by the orexin (hypocretin) system in the perifornical/LH area through the lateral vestibular nucleus in the brainstem. This knowledge provides new insights into the understanding of brain circuitry that c...

journal_title：Neuron

authors： Gao XB,Horvath TL

更新日期：2011-02-24 00:00:00

abstract：:Embryonic mouse neural tubes produce a variety of terminally differentiated cells in vitro, mostly neurons and glia. We report here that some of these cells differentiate into skeletal muscle cells. The possibility of mesoderm contamination was ruled out as follows. First, Dil+ muscle cells were present in cultures fr...

journal_title：Neuron

authors： Tajbakhsh S,Vivarelli E,Cusella-De Angelis G,Rocancourt D,Buckingham M,Cossu G

更新日期：1994-10-01 00:00:00