Muscarinic modulation of sodium current by activation of protein kinase C in rat hippocampal neurons.


:Phosphorylation of brain Na+ channels by protein kinase C (PKC) decreases peak Na+ current and slows macroscopic inactivation, but receptor-activated modulation of Na+ currents via the PKC pathway has not been demonstrated. We have examined modulation of Na+ channels by activation of muscarinic receptors in acutely-isolated hippocampal neurons using whole-cell voltage-clamp recording. Application of the muscarinic agonist carbachol reduced peak Na+ current and slowed macroscopic inactivation at all potentials, without changing the voltage-dependent properties of the channel. These effects were mediated by PKC, since they were eliminated when the specific PKC inhibitor (PKCI19-36) was included in the pipette solution and mimicked by the extracellular application of the PKC activator, OAG. Thus, activation of endogenous muscarinic receptors on hippocampal neurons strongly modulates Na+ channel activity by activation of PKC. Cholinergic input from basal forebrain neurons may have this effect in the hippocampus in vivo.






Cantrell AR,Ma JY,Scheuer T,Catterall WA




Has Abstract


1996-05-01 00:00:00
















  • The metastable brain.

    abstract::Neural ensembles oscillate across a broad range of frequencies and are transiently coupled or "bound" together when people attend to a stimulus, perceive, think, and act. This is a dynamic, self-assembling process, with parts of the brain engaging and disengaging in time. But how is it done? The theory of Coordination...


    pub_type: 杂志文章,评审


    authors: Tognoli E,Kelso JA

    更新日期:2014-01-08 00:00:00

  • Functional topography of connections linking mirror-symmetric maps in the mouse olfactory bulb.

    abstract::In rodents, each main olfactory bulb contains two mirror-symmetric glomerular maps, a feature not found in the initial topographic maps of other sensory systems. Targeting tracer injections to identified glomeruli revealed that isofunctional odor columns-translaminar assemblies connected to a given glomerulus-were spe...


    pub_type: 杂志文章


    authors: Lodovichi C,Belluscio L,Katz LC

    更新日期:2003-04-24 00:00:00

  • Reinforcing rhythms in the sleeping brain with a computerized metronome.

    abstract::Sleep has many inherent benefits, including an important role in memory consolidation. In this issue of Neuron, Ngo et al. (2013b) demonstrate that appropriately timed sounds delivered during sleep can invigorate electrophysiological oscillations conducive to memory stabilization. ...


    pub_type: 评论,杂志文章


    authors: Oudiette D,Santostasi G,Paller KA

    更新日期:2013-05-08 00:00:00

  • Distinct roles of TRP channels in auditory transduction and amplification in Drosophila.

    abstract::Auditory receptor cells rely on mechanically gated channels to transform sound stimuli into neural activity. Several TRP channels have been implicated in Drosophila auditory transduction, but mechanistic studies have been hampered by the inability to record subthreshold signals from receptor neurons. Here, we develop ...


    pub_type: 杂志文章


    authors: Lehnert BP,Baker AE,Gaudry Q,Chiang AS,Wilson RI

    更新日期:2013-01-09 00:00:00

  • Reorganization of striatal inhibitory microcircuits leads to pathological synchrony in the Basal Ganglia.

    abstract::Neural synchronization plays an important role in information flow in the nervous system under healthy and pathological conditions. In this issue of Neuron, Gittis et al. show that reorganization of striatal microcircuits promotes synchronous activity and may underlie the pathological network oscillations at the root ...


    pub_type: 评论,杂志文章


    authors: Belujon P,Grace AA

    更新日期:2011-09-08 00:00:00

  • The mysterious motivational functions of mesolimbic dopamine.

    abstract::Nucleus accumbens dopamine is known to play a role in motivational processes, and dysfunctions of mesolimbic dopamine may contribute to motivational symptoms of depression and other disorders, as well as features of substance abuse. Although it has become traditional to label dopamine neurons as "reward" neurons, this...


    pub_type: 杂志文章,评审


    authors: Salamone JD,Correa M

    更新日期:2012-11-08 00:00:00

  • Fission and uncoating of synaptic clathrin-coated vesicles are perturbed by disruption of interactions with the SH3 domain of endophilin.

    abstract::Coordination between sequential steps in synaptic vesicle endocytosis, including clathrin coat formation, fission, and uncoating, appears to involve proteinprotein interactions. Here, we show that compounds that disrupt interactions of the SH3 domain of endophilin with dynamin and synaptojanin impair synaptic vesicle ...


    pub_type: 杂志文章


    authors: Gad H,Ringstad N,Löw P,Kjaerulff O,Gustafsson J,Wenk M,Di Paolo G,Nemoto Y,Crun J,Ellisman MH,De Camilli P,Shupliakov O,Brodin L

    更新日期:2000-08-01 00:00:00

  • Pain-Induced Negative Affect Is Mediated via Recruitment of The Nucleus Accumbens Kappa Opioid System.

    abstract::Negative affective states affect quality of life for patients suffering from pain. These maladaptive emotional states can lead to involuntary opioid overdose and many neuropsychiatric comorbidities. Uncovering the mechanisms responsible for pain-induced negative affect is critical in addressing these comorbid outcomes...


    pub_type: 杂志文章


    authors: Massaly N,Copits BA,Wilson-Poe AR,Hipólito L,Markovic T,Yoon HJ,Liu S,Walicki MC,Bhatti DL,Sirohi S,Klaas A,Walker BM,Neve R,Cahill CM,Shoghi KI,Gereau RW 4th,McCall JG,Al-Hasani R,Bruchas MR,Morón JA

    更新日期:2019-05-08 00:00:00

  • Specification of neurotransmitter identity by Phox2 proteins in neural crest stem cells.

    abstract::We have investigated the specification of noradrenergic neurotransmitter identity in neural crest stem cells (NCSCs). Retroviral expression of both wild-type and dominant-negative forms of the paired homeodomain transcription factor Phox2a indicates a crucial and direct role for this protein (and/or the closely relate...


    pub_type: 杂志文章


    authors: Lo L,Morin X,Brunet JF,Anderson DJ

    更新日期:1999-04-01 00:00:00

  • Dynamic Nigrostriatal Dopamine Biases Action Selection.

    abstract::Dopamine is thought to play a critical role in reinforcement learning and goal-directed behavior, but its function in action selection remains largely unknown. Here we demonstrate that nigrostriatal dopamine biases ongoing action selection. When mice were trained to dynamically switch the action selected at different ...


    pub_type: 杂志文章


    authors: Howard CD,Li H,Geddes CE,Jin X

    更新日期:2017-03-22 00:00:00

  • Synaptic transmission and plasticity in the absence of AMPA glutamate receptor GluR2 and GluR3.

    abstract::The AMPA glutamate receptor (AMPAR) subunits GluR2 and GluR3 are thought to be important for synaptic targeting/stabilization of AMPARs and the expression of hippocampal long-term depression (LTD). In order to address this hypothesis genetically, we generated and analyzed knockout mice deficient in the expression of b...


    pub_type: 杂志文章


    authors: Meng Y,Zhang Y,Jia Z

    更新日期:2003-07-03 00:00:00

  • Development of direction selectivity in mouse cortical neurons.

    abstract::Previous studies of the ferret visual cortex indicate that the development of direction selectivity requires visual experience. Here, we used two-photon calcium imaging to study the development of direction selectivity in layer 2/3 neurons of the mouse visual cortex in vivo. Surprisingly, just after eye opening nearly...


    pub_type: 杂志文章


    authors: Rochefort NL,Narushima M,Grienberger C,Marandi N,Hill DN,Konnerth A

    更新日期:2011-08-11 00:00:00

  • Synaptic homeostasis on the fast track.

    abstract::Synaptic homeostasis is a phenomenon that prevents the nervous system from descending into chaos. In this issue of Neuron, Frank et al. overturn the notion that synaptic homeostasis at Drosophila NMJs is a slow developmental process. They report that postsynaptic changes are offset within minutes by a homeostatic incr...


    pub_type: 评论,杂志文章,评审


    authors: Macleod GT,Zinsmaier KE

    更新日期:2006-11-22 00:00:00

  • Functional-anatomic correlates of individual differences in memory.

    abstract::Memory abilities differ greatly across individuals. To explore a source of these differences, we characterized the varied strategies people adopt during unconstrained encoding. Participants intentionally encoded object pairs during functional MRI. Principal components analysis applied to a strategy questionnaire revea...


    pub_type: 杂志文章


    authors: Kirchhoff BA,Buckner RL

    更新日期:2006-07-20 00:00:00

  • cTag-PAPERCLIP Reveals Alternative Polyadenylation Promotes Cell-Type Specific Protein Diversity and Shifts Araf Isoforms with Microglia Activation.

    abstract::Alternative polyadenylation (APA) is increasingly recognized to regulate gene expression across different cell types, but obtaining APA maps from individual cell types typically requires prior purification, a stressful procedure that can itself alter cellular states. Here, we describe a new platform, cTag-PAPERCLIP, t...


    pub_type: 杂志文章


    authors: Hwang HW,Saito Y,Park CY,Blachère NE,Tajima Y,Fak JJ,Zucker-Scharff I,Darnell RB

    更新日期:2017-09-13 00:00:00

  • Essential role for the PKC target MARCKS in maintaining dendritic spine morphology.

    abstract::Spine morphology is regulated by intracellular signals, like PKC, that affect cytoskeletal and membrane dynamics. We investigated the role of MARCKS (myristoylated, alanine-rich C-kinase substrate) in dendrites of 3-week-old hippocampal cultures. MARCKS associates with membranes via the combined action of myristoylati...


    pub_type: 杂志文章


    authors: Calabrese B,Halpain S

    更新日期:2005-10-06 00:00:00

  • Robust microcircuit synchronization by inhibitory connections.

    abstract::Microcircuits in different brain areas share similar architectural and biophysical properties with compact motor networks known as central pattern generators (CPGs). Consequently, CPGs have been suggested as valuable biological models for understanding of microcircuit dynamics and particularly, their synchronization. ...


    pub_type: 杂志文章


    authors: Szücs A,Huerta R,Rabinovich MI,Selverston AI

    更新日期:2009-02-12 00:00:00

  • A central source of movement variability.

    abstract::Movements are universally, sometimes frustratingly, variable. When such variability causes error, we typically assume that something went wrong during the movement. The same assumption is made by recent and influential models of motor control. These posit that the principal limit on repeatable performance is neuromusc...


    pub_type: 杂志文章


    authors: Churchland MM,Afshar A,Shenoy KV

    更新日期:2006-12-21 00:00:00

  • Inhibition of high voltage-activated calcium currents by L-glutamate receptor-mediated calcium influx.

    abstract::The modulation of high voltage-activated (HVA) Ca2+ currents by L-glutamate and its agonists was investigated in cultured rat hypothalamic neurons. L-Glutamate and agonists selective for NMDA or non-NMDA receptors reversibly inhibited HVA Ca2+ currents. The putative presynaptic glutamate receptor agonist L-2-amino-4-p...


    pub_type: 杂志文章


    authors: Zeilhofer HU,Müller TH,Swandulla D

    更新日期:1993-05-01 00:00:00

  • RNA-binding proteins hnRNP A2/B1 and CUGBP1 suppress fragile X CGG premutation repeat-induced neurodegeneration in a Drosophila model of FXTAS.

    abstract::Fragile X-associated tremor/ataxia syndrome (FXTAS) is a recently described neurodegenerative disorder of older adult carriers of premutation alleles (60-200 CGG repeats) in the fragile X mental retardation gene (FMR1). It has been proposed that FXTAS is an RNA-mediated neurodegenerative disease caused by the titratio...


    pub_type: 杂志文章


    authors: Sofola OA,Jin P,Qin Y,Duan R,Liu H,de Haro M,Nelson DL,Botas J

    更新日期:2007-08-16 00:00:00

  • Channelopathic pain: a growing but still small list of model disorders.

    abstract::In this issue of Neuron, Kremeyer et al. describe a gain-of-function mutation of TRPA1 that produces a painful disorder, familial episodic pain syndrome. This discovery enlarges the list of ion channels that, when mutated, produce pain. The growing universe of "channelopathic pain" presents some interesting overarchin...


    pub_type: 评论,杂志文章


    authors: Waxman SG

    更新日期:2010-06-10 00:00:00

  • Synapse and Active Zone Assembly in the Absence of Presynaptic Ca2+ Channels and Ca2+ Entry.

    abstract::Presynaptic CaV2 channels are essential for Ca2+-triggered exocytosis. In addition, there are two competing models for their roles in synapse structure. First, Ca2+ channels or Ca2+ entry may control synapse assembly. Second, active zone proteins may scaffold CaV2s to presynaptic release sites, and synapse structure i...


    pub_type: 杂志文章


    authors: Held RG,Liu C,Ma K,Ramsey AM,Tarr TB,De Nola G,Wang SSH,Wang J,van den Maagdenberg AMJM,Schneider T,Sun J,Blanpied TA,Kaeser PS

    更新日期:2020-08-19 00:00:00

  • Pheromones Modulate Learning by Regulating the Balanced Signals of Two Insulin-like Peptides.

    abstract::Social environment modulates learning through unknown mechanisms. Here, we report that a pheromone mixture that signals overcrowding inhibits C. elegans from learning to avoid pathogenic bacteria. We find that learning depends on the balanced signaling of two insulin-like peptides (ILPs), INS-16 and INS-4, which act r...


    pub_type: 杂志文章


    authors: Wu T,Duan F,Yang W,Liu H,Caballero A,Fernandes de Abreu DA,Dar AR,Alcedo J,Ch'ng Q,Butcher RA,Zhang Y

    更新日期:2019-12-18 00:00:00

  • Cerebellar Control of Reach Kinematics for Endpoint Precision.

    abstract::The cerebellum is well appreciated to impart speed, smoothness, and precision to skilled movements such as reaching. How these functions are executed by the final output stage of the cerebellum, the cerebellar nuclei, remains unknown. Here, we identify a causal relationship between cerebellar output and mouse reach ki...


    pub_type: 杂志文章


    authors: Becker MI,Person AL

    更新日期:2019-07-17 00:00:00

  • Essential roles for the Abl and Arg tyrosine kinases in neurulation.

    abstract::The Abl and Arg tyrosine kinases play fundamental roles in the development and function of the central nervous system. Arg is most abundant in adult mouse brain, especially in synapse-rich regions. arg(-/-) mice develop normally but exhibit multiple behavioral abnormalities, suggesting that arg(-/-) brains suffer from...


    pub_type: 杂志文章


    authors: Koleske AJ,Gifford AM,Scott ML,Nee M,Bronson RT,Miczek KA,Baltimore D

    更新日期:1998-12-01 00:00:00

  • The cortical control of movement revisited.

    abstract::Recently, we found that electrical stimulation of motor cortex caused monkeys to make coordinated, complex movements. These evoked movements were arranged across the cortex in a map of spatial locations to which the hand moved. We suggest that some of the subdivisions previously described within primary motor and prem...


    pub_type: 杂志文章,评审


    authors: Graziano MS,Taylor CS,Moore T,Cooke DF

    更新日期:2002-10-24 00:00:00

  • Slit1 and Slit2 cooperate to prevent premature midline crossing of retinal axons in the mouse visual system.

    abstract::During development, retinal ganglion cell (RGC) axons either cross or avoid the midline at the optic chiasm. In Drosophila, the Slit protein regulates midline axon crossing through repulsion. To determine the role of Slit proteins in RGC axon guidance, we disrupted Slit1 and Slit2, two of three known mouse Slit genes....


    pub_type: 杂志文章


    authors: Plump AS,Erskine L,Sabatier C,Brose K,Epstein CJ,Goodman CS,Mason CA,Tessier-Lavigne M

    更新日期:2002-01-17 00:00:00

  • Excitatory and Inhibitory Subnetworks Are Equally Selective during Decision-Making and Emerge Simultaneously during Learning.

    abstract::Inhibitory neurons, which play a critical role in decision-making models, are often simplified as a single pool of non-selective neurons lacking connection specificity. This assumption is supported by observations in the primary visual cortex: inhibitory neurons are broadly tuned in vivo and show non-specific connecti...


    pub_type: 杂志文章


    authors: Najafi F,Elsayed GF,Cao R,Pnevmatikakis E,Latham PE,Cunningham JP,Churchland AK

    更新日期:2020-01-08 00:00:00

  • Two alpha-herpesvirus strains are transported differentially in the rodent visual system.

    abstract::Uptake and transneuronal passage of wild-type and attenuated strains of a swine alpha-herpesvirus (pseudorabies [PRV]) were examined in rat visual projections. Both strains of virus infected subpopulations of retinal ganglion cells and passed transneuronally to infect retino-recipient neurons in the forebrain. However...


    pub_type: 杂志文章


    authors: Card JP,Whealy ME,Robbins AK,Moore RY,Enquist LW

    更新日期:1991-06-01 00:00:00

  • Dysfunction of cortical dendritic integration in neuropathic pain reversed by serotoninergic neuromodulation.

    abstract::Neuropathic pain is caused by long-term modifications of neuronal function in the peripheral nervous system, the spinal cord, and supraspinal areas. Although functional changes in the forebrain are thought to contribute to the development of persistent pain, their significance and precise subcellular nature remain une...


    pub_type: 杂志文章


    authors: Santello M,Nevian T

    更新日期:2015-04-08 00:00:00