Abstract:
:Phosphorylation of brain Na+ channels by protein kinase C (PKC) decreases peak Na+ current and slows macroscopic inactivation, but receptor-activated modulation of Na+ currents via the PKC pathway has not been demonstrated. We have examined modulation of Na+ channels by activation of muscarinic receptors in acutely-isolated hippocampal neurons using whole-cell voltage-clamp recording. Application of the muscarinic agonist carbachol reduced peak Na+ current and slowed macroscopic inactivation at all potentials, without changing the voltage-dependent properties of the channel. These effects were mediated by PKC, since they were eliminated when the specific PKC inhibitor (PKCI19-36) was included in the pipette solution and mimicked by the extracellular application of the PKC activator, OAG. Thus, activation of endogenous muscarinic receptors on hippocampal neurons strongly modulates Na+ channel activity by activation of PKC. Cholinergic input from basal forebrain neurons may have this effect in the hippocampus in vivo.
journal_name
Neuronjournal_title
Neuronauthors
Cantrell AR,Ma JY,Scheuer T,Catterall WAdoi
10.1016/s0896-6273(00)80125-7subject
Has Abstractpub_date
1996-05-01 00:00:00pages
1019-26issue
5eissn
0896-6273issn
1097-4199pii
S0896-6273(00)80125-7journal_volume
16pub_type
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