Abstract：
:Abl is an axonal tyrosine kinase that has yet to be clearly linked to a receptor; Notch is a receptor for which the signaling pathway remains incompletely understood. We show here that Notch and abl mutations interact synergistically to produce synthetic lethality and defects in axon extension. Surprisingly, we cannot account for these axonal aberrations on the basis of changes in cell identity. We show, moreover, that Notch is present in the growth cones of extending axons, and that the Abl accessory protein Disabled binds to a signaling domain of Notch in vitro. We therefore speculate that Disabled and Abl may play a role in Notch signaling in Drosophila axons, perhaps by binding to the Notch intracellular domain.
journal_name
Neuronjournal_title
Neuronauthors
Giniger Edoi
10.1016/s0896-6273(00)81007-7subject
Has Abstractpub_date
1998-04-01 00:00:00pages
667-81issue
4eissn
0896-6273issn
1097-4199pii
S0896-6273(00)81007-7journal_volume
20pub_type
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