An Fgf8-dependent bistable cell migratory event establishes CNS asymmetry.

abstract：:Simple decisions arise from the evaluation of sensory evidence. But decisions are determined by more than just evidence. Individuals establish internal decision criteria that influence how they respond. Where or how decision criteria are established in the brain remains poorly understood. Here, we show that neuronal a...

journal_title：Neuron

authors： Crapse TB,Lau H,Basso MA

更新日期：2018-01-03 00:00:00

abstract：:The precise subunit composition of synaptic ionotropic receptors in the brain is poorly understood. This information is of particular importance with regard to AMPA-type glutamate receptors, the multimeric complexes assembled from GluA1-A4 subunits, as the trafficking of these receptors into and out of synapses is pro...

journal_title：Neuron

authors： Lu W,Shi Y,Jackson AC,Bjorgan K,During MJ,Sprengel R,Seeburg PH,Nicoll RA

更新日期：2009-04-30 00:00:00

abstract：:Chen et al present data describing millisecond interactions in a human hyperdirect pathway that connects the inferior frontal gyrus and the subthalamic nucleus. They study this circuit during a stop-signal task in the context of inhibitory control. ...

journal_title：Neuron

authors： Narayanan NS,Wessel JR,Greenlee JDW

更新日期：2020-05-20 00:00:00

abstract：:Alzheimer's disease is characterized by the deposition of senile plaques and progressive dementia. The molecular mechanisms that couple plaque deposition to neural system failure, however, are unknown. Using transgenic mouse models of AD together with multiphoton imaging, we measured neuronal calcium in individual neu...

journal_title：Neuron

authors： Kuchibhotla KV,Goldman ST,Lattarulo CR,Wu HY,Hyman BT,Bacskai BJ

更新日期：2008-07-31 00:00:00

abstract：:Murine and canine narcolepsy can be caused by mutations of the hypocretin (Hcrt) (orexin) precursor or Hcrt receptor genes. In contrast to these animal models, most human narcolepsy is not familial, is discordant in identical twins, and has not been linked to mutations of the Hcrt system. Thus, the cause of human narc...

journal_title：Neuron

authors： Thannickal TC,Moore RY,Nienhuis R,Ramanathan L,Gulyani S,Aldrich M,Cornford M,Siegel JM

更新日期：2000-09-01 00:00:00

abstract：:Using a novel visual-tactile paradigm in rats, Nikbakht et al. (2018) describe multisensory behavior that outperformed predictions of optimal cue combination (indicating cross-modal synergy) and exposed encoding in PPC neurons (of stimulus and choice signals) that was independent of stimulus modality. ...

journal_title：Neuron

authors： Shalom S,Zaidel A

更新日期：2018-02-07 00:00:00

abstract：:Neurons that release hypocretin/orexin modulate sleep, arousal, and energy homeostasis; the absence of hypocretin results in narcolepsy. Here we present data on the physiological characteristics of these cells, identified with GFP in transgenic mouse brain slices. Hypocretin-1 and -2 depolarized hypocretin neurons by ...

journal_title：Neuron

authors： Li Y,Gao XB,Sakurai T,van den Pol AN

更新日期：2002-12-19 00:00:00

abstract：:Cortical development depends on the active integration of cell-autonomous and extrinsic cues, but the coordination of these processes is poorly understood. Here, we show that the apical complex protein Pals1 and Pten have opposing roles in localizing the Igf1R to the apical, ventricular domain of cerebral cortical pro...

journal_title：Neuron

authors： Lehtinen MK,Zappaterra MW,Chen X,Yang YJ,Hill AD,Lun M,Maynard T,Gonzalez D,Kim S,Ye P,D'Ercole AJ,Wong ET,LaMantia AS,Walsh CA

更新日期：2011-03-10 00:00:00

abstract：:Ventral midbrain dopamine (DA) is unambiguously involved in motivation and behavioral arousal, yet the contributions of other DA populations to these processes are poorly understood. Here, we demonstrate that the dorsal raphe nucleus DA neurons are critical modulators of behavioral arousal and sleep-wake patterning. U...

journal_title：Neuron

authors： Cho JR,Treweek JB,Robinson JE,Xiao C,Bremner LR,Greenbaum A,Gradinaru V

更新日期：2017-06-21 00:00:00

abstract：:To assess the role of exocytotic release in signaling by monoamines, we have disrupted the neuronal vesicular monoamine transporter 2 (VMAT2) gene. VMAT2-/- mice move little, feed poorly, and die within a few days after birth. Monoamine cell groups and their projections are indistinguishable from those of wild-type li...

journal_title：Neuron

authors： Fon EA,Pothos EN,Sun BC,Killeen N,Sulzer D,Edwards RH

更新日期：1997-12-01 00:00:00

abstract：:Using electrical acupuncture, Liu et al. show how electrical stimulation of primary somatosensory neurons at different body regions can tap into discreet autonomic circuits and, depending on the parameters, initiate either a pro- or anti-inflammatory response. ...

journal_title：Neuron

authors： Kupari J,Ernfors P

更新日期：2020-11-11 00:00:00

abstract：:Information processing by a sensory system is reflected in the changes in stimulus representation along its successive processing stages. We measured information content and stimulus-induced redundancy in the neural responses to a set of natural sounds in three successive stations of the auditory pathway-inferior coll...

journal_title：Neuron

authors： Chechik G,Anderson MJ,Bar-Yosef O,Young ED,Tishby N,Nelken I

更新日期：2006-08-03 00:00:00

abstract：:The targeting of sensory afferent neurons in the leech CNS occurs in two discrete steps that are mediated via different carbohydrate recognitions, as shown by molecular perturbations of cultured embryos. A constitutive carbohydrate marker that is generic to all of these neurons mediates their initial defasciculation a...

journal_title：Neuron

authors： Song J,Zipser B

更新日期：1995-03-01 00:00:00

abstract：:Olfactory information is first encoded in a combinatorial fashion by olfactory bulb glomeruli, which individually represent distinct chemical features of odors. This information is then transmitted to piriform (olfactory) cortex, via axons of olfactory bulb mitral and tufted (M/T) cells, where it is presumed to form t...

journal_title：Neuron

authors： Franks KM,Isaacson JS

更新日期：2006-02-02 00:00:00

abstract：:The paraventricular nucleus of the thalamus (PVT) is thought to regulate behavioral responses under emotionally arousing conditions. Reward-associated cues activate PVT neurons; however, the specific PVT efferents regulating reward seeking remain elusive. Using a cued sucrose-seeking task, we manipulated PVT activity ...

journal_title：Neuron

authors： Do-Monte FH,Minier-Toribio A,Quiñones-Laracuente K,Medina-Colón EM,Quirk GJ

更新日期：2017-04-19 00:00:00

abstract：:Vaccinia virus can be used to infect cells in the CNS of frogs, Xenopus laevis, and Rana pipiens, both in vivo and in vitro. In vivo infections were accomplished by injection of viral solution into the tectal ventricle of stage 40-48 tadpoles or by local injections into distinct neural regions. Infections with high ti...

journal_title：Neuron

authors： Wu GY,Zou DJ,Koothan T,Cline HT

更新日期：1995-04-01 00:00:00

abstract：:The molecular specification of central circuits that coordinate expression of innate behaviors in response to specific sensory cues from the environment remains a puzzle. In this issue of Neuron, Choi, Dong, and colleagues used expression profiling and genetic axonal tracing to visualize a hypothalamic point of conver...

journal_title：Neuron

authors： Simerly R

更新日期：2005-05-19 00:00:00

abstract：:Motor behaviors recruit task-specific neuronal ensembles in motor cortices, which are consolidated over subsequent learning. However, little is known about the molecules that can identify the participating neurons and predict the outcomes of the consolidation process. Using a mouse rotarod-learning task, we showed tha...

journal_title：Neuron

authors： Cao VY,Ye Y,Mastwal S,Ren M,Coon M,Liu Q,Costa RM,Wang KH

更新日期：2015-06-17 00:00:00

abstract：:Simultaneous whole-cell recordings were made from the soma and dendrites of cerebellar Purkinje cells in rat brain slices. Sodium action potentials, evoked by either depolarizing current pulses or synaptic stimulation of parallel or climbing fibers, always occurred first at the soma and decreased in amplitude with inc...

journal_title：Neuron

authors： Stuart G,Häusser M

更新日期：1994-09-01 00:00:00

abstract：:Heterotrimeric G proteins mediate a variety of signaling processes by coupling seven-transmembrane receptors to intracellular effector molecules. The Drosophila phototransduction cascade is a G protein-coupled signaling cascade that utilizes a phospholipase C (PLC beta) effector. PLC beta has been shown to be activate...

journal_title：Neuron

authors： Scott K,Becker A,Sun Y,Hardy R,Zuker C

更新日期：1995-10-01 00:00:00

abstract：:The role of cellular interactions in determining the fates of two identified motoneurons in the embryonic zebrafish was investigated by transplanting individual motoneurons from labeled donor embryos to unlabeled hosts. The results suggest that although these cells normally adopt different fates, they form an equivale...

journal_title：Neuron

authors： Eisen JS

更新日期：1992-02-01 00:00:00

abstract：:In this issue of Neuron, Fossati et al. (2016) report that through its domain structure, SRGAP2A, a Rho-GTPase-activating protein, can co-regulate excitatory and inhibitory synapse development, offering a putative evolutionary genetic mechanism for preserving excitatory/inhibitory balance during speciation. ...

journal_title：Neuron

authors： Subramanian J,Nedivi E

更新日期：2016-07-20 00:00:00

abstract：:Two critical amino acids in the visual pigment rhodopsin are Lys-296, the site of attachment of retinal to the protein through a protonated Schiff base linkage, and Glu-113, the Schiff base counterion. Mutation of Lys-296 or Glu-113 results in constitutive activation of opsin, as assayed by its ability to activate tra...

journal_title：Neuron

authors： Robinson PR,Cohen GB,Zhukovsky EA,Oprian DD

更新日期：1992-10-01 00:00:00

abstract：:While there are selective regions of occipitotemporal cortex that respond to faces, letters, and bodies, the large-scale neural organization of most object categories remains unknown. Here, we find that object representations can be differentiated along the ventral temporal cortex by their real-world size. In a functi...

journal_title：Neuron

authors： Konkle T,Oliva A

更新日期：2012-06-21 00:00:00

abstract：:The interactions between cortical and hippocampal circuits are critical for memory formation, yet their basic organization at the neuronal network level is not well understood. Here, we demonstrate that a significant portion of neurons in the medial prefrontal cortex of freely behaving rats are phase locked to the hip...

journal_title：Neuron

authors： Siapas AG,Lubenov EV,Wilson MA

更新日期：2005-04-07 00:00:00

abstract：:Locomotor activity in many species undergoes pronounced alterations in early postnatal life, and environmental cues may be responsible for modifying this process. To determine how these events are reflected in the nervous system, we studied rats reared under two different conditions-the presence or absence of gravity-...

journal_title：Neuron

authors： Inglis FM,Zuckerman KE,Kalb RG

更新日期：2000-05-01 00:00:00

abstract：:Studies on postmortem brains from Parkinson's patients reveal elevated iron in the substantia nigra (SN). Selective cell death in this brain region is associated with oxidative stress, which may be exacerbated by the presence of excess iron. Whether iron plays a causative role in cell death, however, is controversial....

journal_title：Neuron

authors： Kaur D,Yantiri F,Rajagopalan S,Kumar J,Mo JQ,Boonplueang R,Viswanath V,Jacobs R,Yang L,Beal MF,DiMonte D,Volitaskis I,Ellerby L,Cherny RA,Bush AI,Andersen JK

更新日期：2003-03-27 00:00:00

abstract：:Recent results implicating cholesterol metabolism in the pathophysiology of Alzheimer's disease (AD) bring cholesterol to the forefront of AD research. Research from genetics, epidemiology, and cell biology all converge, suggesting that cholesterol plays a central role in the biology of amyloid precursor protein and t...

journal_title：Neuron

authors： Wolozin B

更新日期：2004-01-08 00:00:00

abstract：:Proper mRNA quality control prevents immune activation; when it goes awry, mice and flies develop abnormal behavioral phenotypes. In this issue of Neuron, Johnson et al. (2019) report that inhibiting nonsense-mediated mRNA decay (NMD) contributes to the pathogenesis of neurodevelopmental disorder (NDD) phenotypes by t...

journal_title：Neuron

authors： Kim E,Huh JR

更新日期：2019-11-20 00:00:00

abstract：:GABA, the major inhibitory neurotransmitter in the mammalian brain, binds to GABAA receptors, which form chloride ion channels. The predicted structure of the GABAA receptor places a consensus phosphorylation site for cAMP-dependent protein kinase (PKA) on an intracellular domain of the channel. Phosphorylation by var...

journal_title：Neuron

authors： Porter NM,Twyman RE,Uhler MD,Macdonald RL

更新日期：1990-12-01 00:00:00