Abstract:
:Respiration is a rhythmic activity as well as one that requires responsiveness to internal and external circumstances; both the rhythm and neuromodulatory responses of breathing are controlled by brainstem neurons in the preBötzinger complex (preBötC) and the retrotrapezoid nucleus (RTN), but the specific ion channels essential to these activities remain to be identified. Because deficiency of sodium leak channel, non-selective (Nalcn) causes lethal apnea in humans and mice, we investigated Nalcn function in these neuronal groups. We found that one-third of mice lacking Nalcn in excitatory preBötC neurons died soon after birth; surviving mice developed apneas in adulthood. Interestingly, in both preBötC and RTN neurons, the Nalcn current influences the resting membrane potential, contributes to maintenance of stable network activity, and mediates modulatory responses to the neuropeptide substance P. These findings reveal Nalcn's specific role in both rhythmic stability and responsiveness to neuropeptides within the respiratory network.
journal_name
Neuronjournal_title
Neuronauthors
Yeh SY,Huang WH,Wang W,Ward CS,Chao ES,Wu Z,Tang B,Tang J,Sun JJ,Esther van der Heijden M,Gray PA,Xue M,Ray RS,Ren D,Zoghbi HYdoi
10.1016/j.neuron.2017.03.024subject
Has Abstractpub_date
2017-04-19 00:00:00pages
294-303.e4issue
2eissn
0896-6273issn
1097-4199pii
S0896-6273(17)30236-2journal_volume
94pub_type
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