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Specification of motor axon trajectory by ephrin-B:EphB signaling: symmetrical control of axonal patterning in the developing limb.

Abstract：

:Studies of the innervation of limb muscles by spinal motor neurons have helped to define mechanisms by which axons establish trajectories to their targets. Related motor axons select dorsal or ventral pathways at the base of the limb, raising the question of how these alternate trajectories are specified. EphA signaling has been proposed to control the dorsal trajectory of motor axons in conjunction with other signaling systems, although the respective contributions of each system to motor axon guidance are unclear. We show that the expression of EphB receptors by motor axons, and ephrin-B ligands by limb mesenchymal cells, directs the ventral trajectory of motor axons. Our findings reveal symmetry in the molecular strategies that establish this aspect of nerve-muscle connectivity. The involvement of ephrin:Eph signaling in guiding both sets of motor axons raises the possibility that other signaling systems function primarily to refine or modulate a core Eph signaling program.

journal_name

Neuron

journal_title

Neuron

authors

Luria V,Krawchuk D,Jessell TM,Laufer E,Kania A

doi

10.1016/j.neuron.2008.11.011

subject

Has Abstract

pub_date

2008-12-26 00:00:00

pages

1039-53

issue

6

eissn

0896-6273

issn

1097-4199

pii

S0896-6273(08)00964-1

journal_volume

60

pub_type

杂志文章

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