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Circadian regulation of iodopsin gene expression in embryonic photoreceptors in retinal cell culture.

Abstract：

:A circadian clock regulates a number of diverse physiological functions in the vertebrate eye. In this study, we show that mRNA for the red-sensitive cone pigment, iodopsin, fluctuates with a circadian rhythm in chicken retina. Transcript levels increase in the late afternoon just prior to the time of cone disc shedding. Furthermore, iodopsin mRNA levels are regulated similarly by a circadian oscillator in primary cultures of dispersed embryonic chick retina. Nuclear run-on experiments show that the circadian regulation of iodopsin transcript abundance occurs at the level of gene transcription. Our results provide a demonstration of clock-regulated gene expression in a vertebrate preparation maintained in cell culture.

journal_name

Neuron

journal_title

Neuron

authors

Pierce ME,Sheshberadaran H,Zhang Z,Fox LE,Applebury ML,Takahashi JS

doi

10.1016/0896-6273(93)90161-j

subject

Has Abstract

pub_date

1993-04-01 00:00:00

pages

579-84

issue

4

eissn

0896-6273

issn

1097-4199

pii

0896-6273(93)90161-J

journal_volume

10

pub_type

杂志文章

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