Abstract：
:We used the cerebellum as a model to study the morphogenetic and cellular processes underlying the formation of elaborate brain structures from a simple neural tube, using an inducible genetic fate mapping approach in mouse. We demonstrate how a 90 degrees rotation between embryonic days 9 and 12 converts the rostral-caudal axis of dorsal rhombomere 1 into the medial-lateral axis of the wing-like bilateral cerebellar primordium. With the appropriate use of promoters, we marked specific medial-lateral domains of the cerebellar primordium and derived a positional fate map of the murine cerebellum. We show that the adult medial cerebellum is produced by expansion, rather than fusion, of the thin medial primordium. Furthermore, ventricular-derived cells maintain their original medial-lateral coordinates into the adult, whereas rhombic lip-derived granule cells undergo lateral to medial posterior transverse migrations during foliation. Thus, we show that progressive changes in the axes of the cerebellum underlie its genesis.
journal_name
Neuronjournal_title
Neuronauthors
Sgaier SK,Millet S,Villanueva MP,Berenshteyn F,Song C,Joyner ALdoi
10.1016/j.neuron.2004.12.021subject
Has Abstractpub_date
2005-01-06 00:00:00pages
27-40issue
1eissn
0896-6273issn
1097-4199pii
S0896627304008025journal_volume
45pub_type
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