Origin and dynamics of extraclassical suppression in the lateral geniculate nucleus of the macaque monkey.


:In addition to the classical, center/surround receptive field of neurons in the lateral geniculate nucleus (LGN), there is an extraclassical, nonlinear surround that can strongly suppress LGN responses. This form of suppression likely plays an important role in adjusting the gain of LGN responses to visual stimuli. We performed experiments in alert and anesthetized macaque monkies to quantify extraclassical suppression in the LGN and determine the roles of feedforward and feedback pathways in the generation of LGN suppression. Results show that suppression is significantly stronger among magnocellular neurons than parvocellular neurons and that suppression arises too quickly for involvement from cortical feedback. Furthermore, the amount of suppression supplied by the retina is not significantly different from that in the LGN. These results indicate that extraclassical suppression in the macaque LGN relies on feedforward mechanisms and suggest that suppression in the cortex likely includes a component established in the retina.






Alitto HJ,Usrey WM




Has Abstract


2008-01-10 00:00:00
















  • V3 spinal neurons establish a robust and balanced locomotor rhythm during walking.

    abstract::A robust and well-organized rhythm is a key feature of many neuronal networks, including those that regulate essential behaviors such as circadian rhythmogenesis, breathing, and locomotion. Here we show that excitatory V3-derived neurons are necessary for a robust and organized locomotor rhythm during walking. When V3...


    pub_type: 杂志文章


    authors: Zhang Y,Narayan S,Geiman E,Lanuza GM,Velasquez T,Shanks B,Akay T,Dyck J,Pearson K,Gosgnach S,Fan CM,Goulding M

    更新日期:2008-10-09 00:00:00

  • The transmembrane protein Golden goal regulates R8 photoreceptor axon-axon and axon-target interactions.

    abstract::During Drosophila visual system development, photoreceptor (R) axons choose their correct paths and targets in a step-wise fashion. R axons with different identities make specific pathfinding decisions at different stages during development. We show here that the transmembrane protein Golden goal (Gogo), which is dyna...


    pub_type: 杂志文章


    authors: Tomasi T,Hakeda-Suzuki S,Ohler S,Schleiffer A,Suzuki T

    更新日期:2008-03-13 00:00:00

  • The endocannabinoid anandamide protects neurons during CNS inflammation by induction of MKP-1 in microglial cells.

    abstract::Endocannabinoids are released after brain injury and believed to attenuate neuronal damage by binding to CB(1) receptors and protecting against excitotoxicity. Such excitotoxic brain lesions initially result in primary destruction of brain parenchyma, which attracts macrophages and microglia. These inflammatory cells ...


    pub_type: 杂志文章


    authors: Eljaschewitsch E,Witting A,Mawrin C,Lee T,Schmidt PM,Wolf S,Hoertnagl H,Raine CS,Schneider-Stock R,Nitsch R,Ullrich O

    更新日期:2006-01-05 00:00:00

  • Spatial hearing in echoic environments: the role of the envelope in owls.

    abstract::In the precedence effect, sounds emanating directly from the source are localized preferentially over their reflections. Although most studies have focused on the delay between the onset of a sound and its echo, humans still experience the precedence effect when this onset delay is removed. We tested in barn owls the ...


    pub_type: 杂志文章


    authors: Nelson BS,Takahashi TT

    更新日期:2010-08-26 00:00:00

  • The Contribution of Area MT to Visual Motion Perception Depends on Training.

    abstract::Perceptual decisions require the transformation of raw sensory inputs into cortical representations suitable for stimulus discrimination. One of the best-known examples of this transformation involves the middle temporal area (MT) of the primate visual cortex. Area MT provides a robust representation of stimulus motio...


    pub_type: 杂志文章


    authors: Liu LD,Pack CC

    更新日期:2017-07-19 00:00:00

  • Olfactory bulb: odor signals put into context.

    abstract::In this issue, Doucette and colleagues demonstrate that information related to whether an odor is currently linked to reward can be observed uniquely in population activity in the olfactory bulb, changing our understanding both of what is coded by the first olfactory relay in the CNS and of how this coding is instanti...


    pub_type: 评论,杂志文章


    authors: Katz DB,Maier JX

    更新日期:2011-03-24 00:00:00

  • For love or money: a common neural currency for social and monetary reward.

    abstract::Two papers in the current issue of Neuron (Izuma et al. and Zink et al.) report that activity in specific regions of the brain, especially the striatum, reflects a common signal of reward in both the economic (e.g., money) and social (e.g., praise and status) domains. ...


    pub_type: 评论,杂志文章


    authors: Saxe R,Haushofer J

    更新日期:2008-04-24 00:00:00

  • A role for neuregulin1 signaling in muscle spindle differentiation.

    abstract::The maturation of synaptic structures depends on inductive interactions between axons and their prospective targets. One example of such an interaction is the influence of proprioceptive sensory axons on the differentiation of muscle spindles. We have monitored the expression of three transcription factors, Egr3, Pea3...


    pub_type: 杂志文章


    authors: Hippenmeyer S,Shneider NA,Birchmeier C,Burden SJ,Jessell TM,Arber S

    更新日期:2002-12-19 00:00:00

  • Figuring space by time.

    abstract::Sensory information is encoded both in space and in time. Spatial encoding is based on the identity of activated receptors, while temporal encoding is based on the timing of activation. In order to generate accurate internal representations of the external world, the brain must decode both types of encoded information...


    pub_type: 杂志文章,评审


    authors: Ahissar E,Arieli A

    更新日期:2001-10-25 00:00:00

  • A role for proteoglycans in the guidance of a subset of pioneer axons in cultured embryos of the cockroach.

    abstract::Several molecules involved in the development of the nervous system have specific binding sites for the glycosaminoglycan (GAG) side chains of proteoglycans. Exogenous GAGs should bind to these sites, competitively inhibit interactions with proteoglycans, and perturb development. GAGs added to the culture medium pertu...


    pub_type: 杂志文章


    authors: Wang L,Denburg JL

    更新日期:1992-04-01 00:00:00

  • Primary structure and functional expression of a mammalian skeletal muscle sodium channel.

    abstract::We describe the isolation and characterization of a cDNA encoding the alpha subunit of a new voltage-sensitive sodium channel, microI, from rat skeletal muscle. The 1840 amino acid microI peptide is homologous to alpha subunits from rat brain, but, like the protein from eel electroplax, lacks an extended (approximatel...


    pub_type: 杂志文章


    authors: Trimmer JS,Cooperman SS,Tomiko SA,Zhou JY,Crean SM,Boyle MB,Kallen RG,Sheng ZH,Barchi RL,Sigworth FJ

    更新日期:1989-07-01 00:00:00

  • An unbiased expression screen for synaptogenic proteins identifies the LRRTM protein family as synaptic organizers.

    abstract::Delineating the molecular basis of synapse development is crucial for understanding brain function. Cocultures of neurons with transfected fibroblasts have demonstrated the synapse-promoting activity of candidate molecules. Here, we performed an unbiased expression screen for synaptogenic proteins in the coculture ass...


    pub_type: 杂志文章


    authors: Linhoff MW,Laurén J,Cassidy RM,Dobie FA,Takahashi H,Nygaard HB,Airaksinen MS,Strittmatter SM,Craig AM

    更新日期:2009-03-12 00:00:00

  • Testing the Amyloid Hypothesis with a Humanized AD Mouse Model.

    abstract::In this issue of Neuron, Espuny-Camacho et al. (2017) generate a humanized Alzheimer's disease (AD) model that reveals species-specific vulnerability of human neurons to AD pathology. This model provides key insights for disease mechanism and therapeutic discovery for AD. ...


    pub_type: 杂志文章,评审


    authors: Cahill MK,Huang EJ

    更新日期:2017-03-08 00:00:00

  • An automatic valuation system in the human brain: evidence from functional neuroimaging.

    abstract::According to economic theories, preference for one item over others reveals its rank value on a common scale. Previous studies identified brain regions encoding such values. Here we verify that these regions can valuate various categories of objects and further test whether they still express preferences when attentio...


    pub_type: 杂志文章


    authors: Lebreton M,Jorge S,Michel V,Thirion B,Pessiglione M

    更新日期:2009-11-12 00:00:00

  • Altered representation of the spatial code for odors after olfactory classical conditioning; memory trace formation by synaptic recruitment.

    abstract::In the olfactory bulb of vertebrates or the homologous antennal lobe of insects, odor quality is represented by stereotyped patterns of neuronal activity that are reproducible within and between individuals. Using optical imaging to monitor synaptic activity in the Drosophila antennal lobe, we show here that classical...


    pub_type: 杂志文章


    authors: Yu D,Ponomarev A,Davis RL

    更新日期:2004-05-13 00:00:00

  • cDNA cloning, characterization, and brain region-specific expression of a neuromedin-B-preferring bombesin receptor.

    abstract::Recent binding studies in the central nervous system and other tissues provide evidence that the mammalian bombesin-like peptides, gastrin-releasing peptide (GRP) and neuromedin-B (NMB), exert their numerous physiological effects through at least two different receptors. We describe the structure and expression of a c...


    pub_type: 杂志文章


    authors: Wada E,Way J,Shapira H,Kusano K,Lebacq-Verheyden AM,Coy D,Jensen R,Battery J

    更新日期:1991-03-01 00:00:00

  • The neural basis of perceptual learning.

    abstract::Perceptual learning is a lifelong process. We begin by encoding information about the basic structure of the natural world and continue to assimilate information about specific patterns with which we become familiar. The specificity of the learning suggests that all areas of the cerebral cortex are plastic and can rep...


    pub_type: 杂志文章,评审


    authors: Gilbert CD,Sigman M,Crist RE

    更新日期:2001-09-13 00:00:00

  • ETS transcription factor Erm controls subsynaptic gene expression in skeletal muscles.

    abstract::Accumulation of specific proteins at synaptic structures is essential for synapse assembly and function, but mechanisms regulating local protein enrichment remain poorly understood. At the neuromuscular junction (NMJ), subsynaptic nuclei underlie motor axon terminals within extrafusal muscle fibers and are transcripti...


    pub_type: 杂志文章


    authors: Hippenmeyer S,Huber RM,Ladle DR,Murphy K,Arber S

    更新日期:2007-09-06 00:00:00

  • Leptin activates hypothalamic CART neurons projecting to the spinal cord.

    abstract::The adipocyte-derived hormone leptin decreases body weight in part by activating the sympathetic nervous system, resulting in increased thermogenesis and energy expenditure. We investigated hypothalamic pathways underlying leptin's effects on stimulating the sympathetic nervous system. We found that leptin activates n...


    pub_type: 杂志文章


    authors: Elias CF,Lee C,Kelly J,Aschkenasi C,Ahima RS,Couceyro PR,Kuhar MJ,Saper CB,Elmquist JK

    更新日期:1998-12-01 00:00:00

  • Neuroscience of behavioral and pharmacological treatments for addictions.

    abstract::Although substantial advances have been made in behavioral and pharmacological treatments for addictions, moving treatment development to the next stage may require novel ways of approaching addictions, particularly ways based on new findings regarding the neurobiological underpinnings of addictions that also assimila...


    pub_type: 杂志文章,评审


    authors: Potenza MN,Sofuoglu M,Carroll KM,Rounsaville BJ

    更新日期:2011-02-24 00:00:00

  • The dynamic synapse.

    abstract::The constant dynamic movement of synapses and their components has emerged in the last decades as a key feature of synaptic transmission and its plasticity. Intramolecular protein movements drive conformation changes important to transduce transmitter binding into signaling. Constant cytoskeletal rearrangements power ...


    pub_type: 杂志文章,评审


    authors: Choquet D,Triller A

    更新日期:2013-10-30 00:00:00

  • High-affinity kainate receptor subunits are necessary for ionotropic but not metabotropic signaling.

    abstract::Kainate receptors signal through both ionotropic and metabotropic pathways. The high-affinity subunits, GluK4 and GluK5, are unique among the five receptor subunits, as they do not form homomeric receptors but modify the properties of heteromeric assemblies. Disruption of the Grik4 gene locus resulted in a significant...


    pub_type: 杂志文章


    authors: Fernandes HB,Catches JS,Petralia RS,Copits BA,Xu J,Russell TA,Swanson GT,Contractor A

    更新日期:2009-09-24 00:00:00

  • Petrified or aroused with fear: the central amygdala takes the lead.

    abstract::The behavioral expression of fear ranges from active, cognitive responses to passive, freezing-like reactions. In this issue of Neuron, Gozzi, Jain, and colleagues suggest that neurons in the central amygdala orchestrate output signals toward either the brainstem or cholinergic basal forebrain and thereby can shift fe...


    pub_type: 评论,杂志文章


    authors: Pape HC

    更新日期:2010-08-26 00:00:00

  • Distinct Sources of Deterministic and Stochastic Components of Action Timing Decisions in Rodent Frontal Cortex.

    abstract::The selection and timing of actions are subject to determinate influences such as sensory cues and internal state as well as to effectively stochastic variability. Although stochastic choice mechanisms are assumed by many theoretical models, their origin and mechanisms remain poorly understood. Here we investigated th...


    pub_type: 杂志文章


    authors: Murakami M,Shteingart H,Loewenstein Y,Mainen ZF

    更新日期:2017-05-17 00:00:00

  • Channelopathic pain: a growing but still small list of model disorders.

    abstract::In this issue of Neuron, Kremeyer et al. describe a gain-of-function mutation of TRPA1 that produces a painful disorder, familial episodic pain syndrome. This discovery enlarges the list of ion channels that, when mutated, produce pain. The growing universe of "channelopathic pain" presents some interesting overarchin...


    pub_type: 评论,杂志文章


    authors: Waxman SG

    更新日期:2010-06-10 00:00:00

  • Animal models of PD: pieces of the same puzzle?

    abstract::Parkinson's disease (PD) is a common neurodegenerative disorder with no known cure. The etiology of PD is likely due, in part, to combinations of genetic susceptibilities and environmental factors. In rare familial cases, PD is due to genetic mutations. A number of new genetic and toxin models of PD and advances in ol...


    pub_type: 杂志文章,评审


    authors: Dawson T,Mandir A,Lee M

    更新日期:2002-07-18 00:00:00

  • Visinin: a novel calcium binding protein expressed in retinal cone cells.

    abstract::Visinin is a retinal cone cell-specific protein (molecular weight 24,000, pI 5.1). To investigate its function, visinin cDNA was isolated from a chick retinal lambda gt11 cDNA library, using anti-visinin serum. The beta-galactosidase-visinin fusion protein was used for purifying epitope-selected antibody. The purified...


    pub_type: 杂志文章


    authors: Yamagata K,Goto K,Kuo CH,Kondo H,Miki N

    更新日期:1990-03-01 00:00:00

  • Shunting inhibition modulates neuronal gain during synaptic excitation.

    abstract::Neuronal gain control is important for processing information in the brain. Shunting inhibition is not thought to control gain since it shifts input-output relationships during tonic excitation rather than changing their slope. Here we show that tonic inhibition reduces the gain and shifts the offset of cerebellar gra...


    pub_type: 杂志文章


    authors: Mitchell SJ,Silver RA

    更新日期:2003-05-08 00:00:00

  • Prefrontal phase locking to hippocampal theta oscillations.

    abstract::The interactions between cortical and hippocampal circuits are critical for memory formation, yet their basic organization at the neuronal network level is not well understood. Here, we demonstrate that a significant portion of neurons in the medial prefrontal cortex of freely behaving rats are phase locked to the hip...


    pub_type: 杂志文章


    authors: Siapas AG,Lubenov EV,Wilson MA

    更新日期:2005-04-07 00:00:00

  • RIM-binding protein links synaptic homeostasis to the stabilization and replenishment of high release probability vesicles.

    abstract::Here we define activities of RIM-binding protein (RBP) that are essential for baseline neurotransmission and presynaptic homeostatic plasticity. At baseline, rbp mutants have a ∼10-fold decrease in the apparent Ca(2+) sensitivity of release that we attribute to (1) impaired presynaptic Ca(2+) influx, (2) looser coupli...


    pub_type: 杂志文章


    authors: Müller M,Genç Ö,Davis GW

    更新日期:2015-03-04 00:00:00