Abstract：
:Formation of the normal mammalian cerebral cortex requires the migration of GABAergic inhibitory interneurons from an extracortical origin, the lateral ganglionic eminence (LGE). Mechanisms guiding the migratory direction of these neurons, or other neurons in the neocortex, are not well understood. We have used an explant assay to study GABAergic neuronal migration and found that the ventricular zone (VZ) of the LGE is repulsive to GABAergic neurons. Furthermore, the secreted protein Slit is a chemorepellent guiding the migratory direction of GABAergic neurons, and blockade of endogenous Slit signaling inhibits the repulsive activity in the VZ. These results have revealed a cellular source of guidance for GABAergic neurons, demonstrated a molecular cue important for cortical development, and suggested a guidance mechanism for the migration of extracortical neurons into the neocortex.
journal_name
Neuronjournal_title
Neuronauthors
Zhu Y,Li H,Zhou L,Wu JY,Rao Ydoi
10.1016/s0896-6273(00)80801-6subject
Has Abstractpub_date
1999-07-01 00:00:00pages
473-85issue
3eissn
0896-6273issn
1097-4199pii
S0896-6273(00)80801-6journal_volume
23pub_type
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