Abstract：
:TRP and TRPL are two light-sensitive cation channel subunits required for the Drosophila photoresponse; however, our understanding of the identities, subunit composition, and function of the light-responsive channels is incomplete. To explain the residual photoresponse that remains in the trp mutant, a third TRP-related subunit has previously been proposed to function with TRPL. Here, we identify such a subunit, TRPgamma. We show that TRPgamma is highly enriched in photoreceptor cells and preferentially heteromultimerizes with TRPL in vitro and in vivo. The N-terminal domain of TRPgamma dominantly suppressed the TRPL-dependent photoresponse, indicating that TRPgamma-TRPL heteromultimers contribute to the photoresponse. While TRPL and TRPgamma homomultimers are constitutively active, we demonstrate that TRPL-TRPgamma heteromultimers form a regulated phospholipase C- (PLC-) stimulated channel.
journal_name
Neuronjournal_title
Neuronauthors
Xu XZ,Chien F,Butler A,Salkoff L,Montell Cdoi
10.1016/s0896-6273(00)81201-5subject
Has Abstractpub_date
2000-06-01 00:00:00pages
647-57issue
3eissn
0896-6273issn
1097-4199pii
S0896-6273(00)81201-5journal_volume
26pub_type
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