Abstract:
:Clathrin-mediated endocytosis of synaptic vesicles requires molecular rearrangements of proteins as well as lipids. In this issue of Neuron, Schuske et al. and Verstreken et al. show that the lipid-modifying enzyme endophilin recruits and stabilizes the polyphosphoinositide phosphatase synaptojanin at nerve terminals. This remarkable pairing of two enzymatic activities promotes multiple steps of clathrin-mediated endocytosis of synaptic vesicles.
journal_name
Neuronjournal_title
Neuronauthors
Song W,Zinsmaier KEdoi
10.1016/s0896-6273(03)00726-8subject
Has Abstractpub_date
2003-11-13 00:00:00pages
665-7issue
4eissn
0896-6273issn
1097-4199pii
S0896627303007268journal_volume
40pub_type
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