Abstract:
:In cerebellar Purkinje cell dendrites, heterosynaptic calcium signaling induced by the proximal climbing fiber (CF) input controls plasticity at distal parallel fiber (PF) synapses. The substrate and regulation of this long-range dendritic calcium signaling are poorly understood. Using high-speed calcium imaging, we examine the role of active dendritic conductances. Under basal conditions, CF stimulation evokes T-type calcium signaling displaying sharp proximodistal decrement. Combined mGluR1 receptor activation and depolarization, two activity-dependent signals, unlock P/Q calcium spikes initiation and propagation, mediating efficient CF signaling at distal sites. These spikes are initiated in proximal smooth dendrites, independently from somatic sodium action potentials, and evoke high-frequency bursts of all-or-none fast-rising calcium transients in PF spines. Gradual calcium spike burst unlocking arises from increasing inactivation of mGluR1-modulated low-threshold A-type potassium channels located in distal dendrites. Evidence for graded activity-dependent CF calcium signaling at PF synapses refines current views on cerebellar supervised learning rules.
journal_name
Neuronjournal_title
Neuronauthors
Otsu Y,Marcaggi P,Feltz A,Isope P,Kollo M,Nusser Z,Mathieu B,Kano M,Tsujita M,Sakimura K,Dieudonné Sdoi
10.1016/j.neuron.2014.08.035subject
Has Abstractpub_date
2014-10-01 00:00:00pages
137-151issue
1eissn
0896-6273issn
1097-4199pii
S0896-6273(14)00736-3journal_volume
84pub_type
杂志文章相关文献
NEURON文献大全abstract::Phosphatidylinositol 3-kinase (PI3K)-dependent phosphoinositide signaling has been implicated in diverse cellular systems coupled to receptors for many different ligands, but the extent to which it functions in sensory transduction is yet to be determined. We now report that blocking PI3K activity increases odorant-ev...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(02)00610-4
更新日期:2002-02-28 00:00:00
abstract::Regulation of AMPA-type glutamate receptor (AMPAR) number at synapses is a major mechanism for controlling synaptic strength during homeostatic scaling in response to global changes in neural activity. We show that the secreted guidance cue semaphorin 3F (Sema3F) and its neuropilin-2 (Npn-2)/plexinA3 (PlexA3) holorece...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2017.10.029
更新日期:2017-12-06 00:00:00
abstract::The process by which neural circuitry in the brain plans and executes movements is not well understood. Until recently, most available data were limited either to single-neuron electrophysiological recordings or to measures of aggregate field or metabolism. Neither approach reveals how individual neurons' activities a...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2011.05.047
更新日期:2011-08-11 00:00:00
abstract::The processing of sensory information varies widely across behavioral states. However, little is known about how behavioral states modulate the intracellular activity of cortical neurons to effect changes in sensory responses. Here, we performed whole-cell recordings from neurons in upper-layer primary visual cortex o...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2013.08.007
更新日期:2013-10-16 00:00:00
abstract::Interactions between the hippocampus and prefrontal cortex (PFC) are critical for learning and memory. Hippocampal activity during awake sharp-wave ripple (SWR) events is important for spatial learning, and hippocampal SWR activity often represents past or potential future experiences. Whether or how this reactivation...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2016.02.010
更新日期:2016-04-06 00:00:00
abstract::Neuroscience relies on techniques for imaging the structure and dynamics of neural circuits, but the cell bodies of individual neurons are often obscured by overlapping fluorescence from axons and dendrites in surrounding neuropil. Here, we describe two strategies for using the ribosome to restrict the expression of f...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2020.05.005
更新日期:2020-08-05 00:00:00
abstract::In the developing nervous system, neurons are generated at sites distant from their ultimate location. In the vertebrate CNS, neurons utilize distinct migration strategies to reach their ultimate residence. This review discusses the contribution of tangential migration to the architectural development of the cerebral ...
journal_title:Neuron
pub_type: 评论,杂志文章,评审
doi:10.1016/s0896-6273(01)00370-1
更新日期:2001-08-02 00:00:00
abstract::Sweet and bitter taste distinguishes good food sources from potential toxins, but what happens when these tastants are mixed? In this issue of Neuron, Jeong et al. (2013) show that in Drosophila, bitter compounds act through an extracellular odorant-binding protein to inhibit sweet-responsive neurons and block the res...
journal_title:Neuron
pub_type: 评论,杂志文章
doi:10.1016/j.neuron.2013.07.038
更新日期:2013-08-21 00:00:00
abstract::Mouse vision is based on the parallel output of more than 30 functional types of retinal ganglion cells (RGCs). Little is known about how representations of visual information change between retina and dorsolateral geniculate nucleus (dLGN) of the thalamus, the main relay between retina and cortex. Here, we functional...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2019.01.040
更新日期:2019-04-17 00:00:00
abstract::The mechanisms that constrain memory formation are of special interest because they provide insights into the brain's memory management systems and potential avenues for correcting cognitive disorders. RNAi knockdown in the Drosophila mushroom body neurons (MBn) of a newly discovered memory suppressor gene, Solute Car...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2016.03.017
更新日期:2016-05-04 00:00:00
abstract::Propagation in higher animals requires the efficient and accurate display of innate mating behaviors. In Drosophila melanogaster, male courtship consists of a stereotypic sequence of behaviors involving multiple sensory modalities, such as vision, audition, and chemosensation. For example, taste bristles located in th...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(03)00542-7
更新日期:2003-09-11 00:00:00
abstract::Synaptic homeostasis is a phenomenon that prevents the nervous system from descending into chaos. In this issue of Neuron, Frank et al. overturn the notion that synaptic homeostasis at Drosophila NMJs is a slow developmental process. They report that postsynaptic changes are offset within minutes by a homeostatic incr...
journal_title:Neuron
pub_type: 评论,杂志文章,评审
doi:10.1016/j.neuron.2006.11.006
更新日期:2006-11-22 00:00:00
abstract::Kainate receptors signal through both ionotropic and metabotropic pathways. The high-affinity subunits, GluK4 and GluK5, are unique among the five receptor subunits, as they do not form homomeric receptors but modify the properties of heteromeric assemblies. Disruption of the Grik4 gene locus resulted in a significant...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2009.08.010
更新日期:2009-09-24 00:00:00
abstract::To investigate the role of the pathogenic prion protein (PrP(Sc)) in controlling susceptibility to foreign prions, two Syrian hamster (SHa) prion strains, Sc237 and DY, were transmitted to transgenic mice expressing chimeric SHa/mouse PrP genes, Tg(MH2M). First passage of SHa(Sc237) prions exhibited prolonged incubati...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(02)00726-2
更新日期:2002-06-13 00:00:00
abstract::We have investigated ubiquitinated paired helical filaments, which produce a proteinaceous smear in SDS-polyacrylamide gel electrophoresis and immunoblotting. The smear consisted largely of the carboxy-terminal portion of tau and ubiquitin. The ubiquitin-targeted protein was identified as tau in paired helical filamen...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(93)90063-w
更新日期:1993-06-01 00:00:00
abstract::The mechanism coupling exocytosis and endocytosis remains to be elucidated at central synapses. Here, we show that the mechanism linking these two processes is dependent on microdomain-[Ca2+](i) similar to that which triggers exocytosis, as well as the exocytotic protein synaptobrevin/VAMP. Furthermore, block of endoc...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2009.06.010
更新日期:2009-07-30 00:00:00
abstract::Learning can be characterized as the extraction of reliable predictions about stimulus occurrences from past experience. In two experiments, we investigated the interval of temporal integration of previous learning trials in different brain regions using implicit and explicit Pavlovian fear conditioning with a dynamic...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2005.06.008
更新日期:2005-07-21 00:00:00
abstract::Midbrain dopamine (DA) neurons are not homogeneous but differ in their molecular properties and responses to external stimuli. We examined whether the modulation of excitatory synapses on DA neurons by rewarding or aversive stimuli depends on the brain area to which these DA neurons project. We identified DA neuron su...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2011.03.025
更新日期:2011-06-09 00:00:00
abstract::In mammals, the osmolality of the extracellular fluid (ECF) is highly stable despite radical changes in salt/water intake and excretion. Afferent systems are required to detect hypo- or hyperosmotic shifts in the ECF to trigger homeostatic control of osmolality. In humans, a pressor reflex is triggered by simply drink...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2010.12.028
更新日期:2011-01-27 00:00:00
abstract::The dopaminergic D3 receptor (D3R) is emerging as an antagonist of sensitized behavior induced by addictive drugs such as cocaine. New work by Wang and coworkers in this issue of Neuron now identifies CaMKII as an important negative regulator of the D3R. CaMKII relieves the D3R-mediated inhibition on sensitized behavi...
journal_title:Neuron
pub_type: 评论,杂志文章
doi:10.1016/j.neuron.2009.01.025
更新日期:2009-02-12 00:00:00
abstract::Brandon et al. (2014) show that the formation of place cell representations in new environments is preserved under septal inactivation, and is thus likely independent of the hippocampal theta rhythm and, by implication, the firing of entorhinal grid cells and the process of path integration. ...
journal_title:Neuron
pub_type: 评论,杂志文章
doi:10.1016/j.neuron.2014.05.011
更新日期:2014-05-21 00:00:00
abstract::Sequential neural activity patterns are as ubiquitous as the outputs they drive, which include motor gestures and sequential cognitive processes. Neural sequences are long, compared to the activation durations of participating neurons, and sequence coding is sparse. Numerous studies demonstrate that spike-time-depende...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2010.02.003
更新日期:2010-02-25 00:00:00
abstract::Autism spectrum disorders (ASD) are a group of neurodevelopmental disorders with symptoms including social deficits, anxiety, and communication difficulties. However, ASD pathogenic mechanisms are poorly understood. Mutations of CUL3, which encodes Cullin 3 (CUL3), a component of an E3 ligase complex, are thought of a...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2019.10.035
更新日期:2020-02-05 00:00:00
abstract::The dorsal anterior cingulate cortex (dACC) has a near-ubiquitous presence in the neuroscience of cognitive control. It has been implicated in a diversity of functions, from reward processing and performance monitoring to the execution of control and action selection. Here, we propose that this diversity can be unders...
journal_title:Neuron
pub_type: 杂志文章,评审
doi:10.1016/j.neuron.2013.07.007
更新日期:2013-07-24 00:00:00
abstract::In this issue, Gill et al. apply holographic optogenetic stimulation in the olfactory bulb to control select neuronal ensembles in 3D. This approach allows them to dissociate the contribution of temporal spike features and spike rate to stimulus detection. ...
journal_title:Neuron
pub_type: 评论,杂志文章
doi:10.1016/j.neuron.2020.10.007
更新日期:2020-10-28 00:00:00
abstract::Lattice-like structures known as perineuronal nets (PNNs) are key components of the extracellular matrix (ECM). Once fully crystallized by adulthood, they are largely stable throughout life. Contrary to previous reports that PNNs inhibit processes involving plasticity, here we report that the dynamic regulation of PNN...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2017.06.007
更新日期:2017-07-05 00:00:00
abstract::Olfactory information is first encoded in a combinatorial fashion by olfactory bulb glomeruli, which individually represent distinct chemical features of odors. This information is then transmitted to piriform (olfactory) cortex, via axons of olfactory bulb mitral and tufted (M/T) cells, where it is presumed to form t...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2005.12.026
更新日期:2006-02-02 00:00:00
abstract::The structural basis for the synthesis of specific proteins within distinct intraneuronal compartments is unknown. We studied the distribution of poly(A) mRNA within cultured cerebrocortical neurons using high resolution in situ hybridization to identify cytoskeletal components that may anchor mRNA. After 1 day in cul...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(94)90213-5
更新日期:1994-03-01 00:00:00
abstract::We utilized the Cre-LoxP system to establish erbB2 conditional mutant mice in order to investigate the role of erbB2 in postnatal development of the enteric nervous system. The erbB2/nestin-Cre conditional mutants exhibit retarded growth, distended colons, and premature death, resembling human Hirschsprung's disease. ...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(02)01128-5
更新日期:2003-01-09 00:00:00
abstract::Inhibitors in myelin play a major role in preventing spontaneous axonal regeneration after CNS injury. Elevation of cAMP overcomes this inhibition, in a transcription-dependent manner, through the upregulation of Arginase I (Arg I) and increased synthesis of polyamines. Here, we show that the cAMP effect requires acti...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2004.10.030
更新日期:2004-11-18 00:00:00