Abstract:
:Interactions between the hippocampus and prefrontal cortex (PFC) are critical for learning and memory. Hippocampal activity during awake sharp-wave ripple (SWR) events is important for spatial learning, and hippocampal SWR activity often represents past or potential future experiences. Whether or how this reactivation engages the PFC, and how reactivation might interact with ongoing patterns of PFC activity, remains unclear. We recorded hippocampal CA1 and PFC activity in animals learning spatial tasks and found that many PFC cells showed spiking modulation during SWRs. Unlike in CA1, SWR-related activity in PFC comprised both excitation and inhibition of distinct populations. Within individual SWRs, excitation activated PFC cells with representations related to the concurrently reactivated hippocampal representation, while inhibition suppressed PFC cells with unrelated representations. Thus, awake SWRs mark times of strong coordination between hippocampus and PFC that reflects structured reactivation of representations related to ongoing experience.
journal_name
Neuronjournal_title
Neuronauthors
Jadhav SP,Rothschild G,Roumis DK,Frank LMdoi
10.1016/j.neuron.2016.02.010subject
Has Abstractpub_date
2016-04-06 00:00:00pages
113-27issue
1eissn
0896-6273issn
1097-4199pii
S0896-6273(16)00103-3journal_volume
90pub_type
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