Abstract：
:The mechanism coupling exocytosis and endocytosis remains to be elucidated at central synapses. Here, we show that the mechanism linking these two processes is dependent on microdomain-[Ca2+](i) similar to that which triggers exocytosis, as well as the exocytotic protein synaptobrevin/VAMP. Furthermore, block of endocytosis has a limited, retrograde action on exocytosis, delaying recruitment of release-ready vesicles and enhancing short-term depression. This effect sets in so rapidly that it cannot be explained by the nonavailability of recycled vesicles. Rather, we postulate that perturbation of a step linking exocytosis and endocytosis temporarily prevents new vesicles from docking at specialized sites for exocytosis.
journal_name
Neuronjournal_title
Neuronauthors
Hosoi N,Holt M,Sakaba Tdoi
10.1016/j.neuron.2009.06.010subject
Has Abstractpub_date
2009-07-30 00:00:00pages
216-29issue
2eissn
0896-6273issn
1097-4199pii
S0896-6273(09)00463-2journal_volume
63pub_type
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