Abstract：
:Kainate receptors signal through both ionotropic and metabotropic pathways. The high-affinity subunits, GluK4 and GluK5, are unique among the five receptor subunits, as they do not form homomeric receptors but modify the properties of heteromeric assemblies. Disruption of the Grik4 gene locus resulted in a significant reduction in synaptic kainate receptor currents. Moreover, ablation of GluK4 and GluK5 caused complete loss of synaptic ionotropic kainate receptor function. The principal subunits were distributed away from postsynaptic densities and presynaptic active zones. There was also a profound alteration in the activation properties of the remaining kainate receptors. Despite this, kainate receptor-mediated inhibition of the slow afterhyperpolarization current (I(sAHP)), which is dependent on metabotropic pathways, was intact in GluK4/GluK5 knockout mice. These results uncover a previously unknown obligatory role for the high-affinity subunits for ionotropic kainate receptor function and further demonstrate that kainate receptor participation in metabotropic signaling pathways does not require their classic role as ion channels.
journal_name
Neuronjournal_title
Neuronauthors
Fernandes HB,Catches JS,Petralia RS,Copits BA,Xu J,Russell TA,Swanson GT,Contractor Adoi
10.1016/j.neuron.2009.08.010subject
Has Abstractpub_date
2009-09-24 00:00:00pages
818-29issue
6eissn
0896-6273issn
1097-4199pii
S0896-6273(09)00620-5journal_volume
63pub_type
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