Facilitation of NMDAR-independent LTP and spatial learning in mutant mice lacking ryanodine receptor type 3.

abstract：:The neocortex of mammals is composed of cortical fields that have a unique organization associated with the animal's ecological niche and lifestyle. Each cortical field has a specific pattern of connections with other cortical fields and brain structures, and together they comprise a neocortical network that generates...

journal_title：Neuron

authors： Krubitzer L

更新日期：2007-10-25 00:00:00

abstract：:Telling time and anticipating when external events will happen is among the most important tasks the brain performs. Yet the neural mechanisms underlying timing remain elusive. One theory proposes that timing is a general and intrinsic computation of cortical circuits. We tested this hypothesis using electrical and op...

journal_title：Neuron

authors： Goel A,Buonomano DV

更新日期：2016-07-20 00:00:00

abstract：:Nicotinic acetylcholine receptors (AChRs) immunoaffinity-purified from brains are composed of only two kinds of subunits rather than the four kinds present in muscle-type AChRs. Here we report the N-terminal protein sequences of the structural subunits of AChRs from rat and chicken brains and the cloning of full-lengt...

journal_title：Neuron

authors： Schoepfer R,Whiting P,Esch F,Blacher R,Shimasaki S,Lindstrom J

更新日期：1988-05-01 00:00:00

abstract：:Olfaction is a principal sensory modality in rodents, and rats quickly learn to discriminate between odors and to associate odor with reward. Here we show that such olfactory discrimination (OD) learning consists of two phases with distinct cellular mechanisms: an initial NMDAR-sensitive phase in which the animals acq...

journal_title：Neuron

authors： Quinlan EM,Lebel D,Brosh I,Barkai E

更新日期：2004-01-22 00:00:00

abstract：:In this issue, Doucette and colleagues demonstrate that information related to whether an odor is currently linked to reward can be observed uniquely in population activity in the olfactory bulb, changing our understanding both of what is coded by the first olfactory relay in the CNS and of how this coding is instanti...

journal_title：Neuron

authors： Katz DB,Maier JX

更新日期：2011-03-24 00:00:00

abstract：:Molecular determinants of threshold sensitivity of mammalian mechanoreceptors are unknown. Here, we identify a mechanosensitive (MS) K(+) current (IKmech) that governs mechanical threshold and adaptation of distinct populations of mechanoreceptors. Toxin profiling and transgenic mouse studies indicate that IKmech is c...

journal_title：Neuron

authors： Hao J,Padilla F,Dandonneau M,Lavebratt C,Lesage F,Noël J,Delmas P

更新日期：2013-03-06 00:00:00

abstract：:Little is known about genetic mechanisms that regulate the ratio of cortical excitatory and inhibitory neurons. We show that NPAS1 and NPAS3 transcription factors (TFs) are expressed in progenitor domains of the mouse basal ganglia (subpallium, MGE, and CGE). NPAS1(-/-) mutants had increased proliferation, ERK signali...

journal_title：Neuron

authors： Stanco A,Pla R,Vogt D,Chen Y,Mandal S,Walker J,Hunt RF,Lindtner S,Erdman CA,Pieper AA,Hamilton SP,Xu D,Baraban SC,Rubenstein JL

更新日期：2014-12-03 00:00:00

abstract：:The M current regulates neuronal excitability, with its amplitude resulting from high open probability modal M channel behavior. The M current is affected by changing intracellular calcium levels. It is proposed that internal calcium acts by regulating M channel modal gating. Intracellular application of a preactivate...

journal_title：Neuron

authors： Marrion NV

更新日期：1996-01-01 00:00:00

abstract：:A neural network can sustain and switch between different activity patterns to execute multiple behaviors. By monitoring the decision making for directional locomotion through motor circuit calcium imaging in behaving Caenorhabditis elegans (C. elegans), we reveal that C. elegans determines the directionality of movem...

journal_title：Neuron

authors： Kawano T,Po MD,Gao S,Leung G,Ryu WS,Zhen M

更新日期：2011-11-17 00:00:00

abstract：:Imaging large-scale circuit dynamics is crucial to understanding brain function, but most techniques have a limited depth of field. Here, we describe volumetric functional ultrasound imaging (vfUSI), a platform for brain-wide vfUSI of hemodynamic activity in awake head-fixed mice. We combined a high-frequency 1,024-ch...

journal_title：Neuron

authors： Brunner C,Grillet M,Sans-Dublanc A,Farrow K,Lambert T,Macé E,Montaldo G,Urban A

更新日期：2020-12-09 00:00:00

abstract：:Perception of the thermal environment begins with the activation of peripheral thermosensory neurons innervating the body surface. To understand how temperature is represented in vivo, we used genetically encoded calcium indicators to measure temperature-evoked responses in hundreds of neurons across the trigeminal ga...

journal_title：Neuron

authors： Yarmolinsky DA,Peng Y,Pogorzala LA,Rutlin M,Hoon MA,Zuker CS

更新日期：2016-12-07 00:00:00

abstract：:Calcium/calmodulin kinase II (CaMKII) is required for LTP and experience-dependent potentiation in the barrel cortex. Here, we find that whisker deprivation increases LTP in the layer IV to II/III pathway and that PKA antagonists block the additional LTP. No LTP was seen in undeprived CaMKII-T286A mice, but whisker de...

journal_title：Neuron

authors： Hardingham N,Wright N,Dachtler J,Fox K

更新日期：2008-12-10 00:00:00

abstract：:In this issue of Neuron, Wahl et al. demonstrate via invasive recordings from Deep Brain Stimulation leads that the thalamus (but not basal ganglia) is sensitive to certain linguistic violations, consistent with a subcortical role in selective recruitment of language-related cortical areas. ...

journal_title：Neuron

authors： Münte TF,Kutas M

更新日期：2008-09-11 00:00:00

abstract：:Activation of kainate receptors causes Co2+ influx into neurons, type-2 astrocytes, and O-2A progenitor cells. Agonist-activated Co2+ uptake can be performed using cultured cells or fresh tissue slices. Based on the pattern of response to kainate, glutamate, and quisqualate, three functionally different kainate-activa...

journal_title：Neuron

authors： Pruss RM,Akeson RL,Racke MM,Wilburn JL

更新日期：1991-09-01 00:00:00

abstract：:The brain mechanisms underlying visual object categorization remain unclear. In this issue of Neuron, Minamimoto and colleagues introduce a novel task that associates each category with a different incentive value, and they demonstrate that it can be learned within a single session even after ablation of the lateral p...

journal_title：Neuron

authors： Buckley MJ,Sigala N

更新日期：2010-05-27 00:00:00

abstract：:Neuronal Ca2+ channels are key transducers coupling excitability to cellular function. As such, they are tightly regulated by multiple G protein-signaling pathways that finely tune their activity. In addition to fast, direct G(beta)gamma modulation of Ca2+ channels, a slower Galpha(q/11)-mediated mechanism has remaine...

journal_title：Neuron

authors： Delmas P,Coste B,Gamper N,Shapiro MS

更新日期：2005-07-21 00:00:00

abstract：:Does our understanding of the human brain remain incomplete without a proper understanding of how the brain processes music? Here, the author makes a passionate plea for the use of music in the investigation of human emotion and its brain correlates, arguing that music can change activity in all brain structures assoc...

journal_title：Neuron

authors： Koelsch S

更新日期：2018-06-27 00:00:00

abstract：:We have examined GABAA receptor activation by making rapid applications of GABA to outside-out patches excised from cultured postnatal rat cerebellar neurons. The rate of development of current increases with increasing GABA concentration from a low to a high concentration asymptote. The low concentration asymptote is...

journal_title：Neuron

authors： Maconochie DJ,Zempel JM,Steinbach JH

更新日期：1994-01-01 00:00:00

abstract：:AMPA-type glutamate receptors (AMPARs) are responsible for a variety of processes in the mammalian brain including fast excitatory neurotransmission, postsynaptic plasticity, or synapse development. Here, with comprehensive and quantitative proteomic analyses, we demonstrate that native AMPARs are macromolecular compl...

journal_title：Neuron

authors： Schwenk J,Harmel N,Brechet A,Zolles G,Berkefeld H,Müller CS,Bildl W,Baehrens D,Hüber B,Kulik A,Klöcker N,Schulte U,Fakler B

更新日期：2012-05-24 00:00:00

abstract：:To investigate the role of intracellular Ca2+ in the survival of developing neurons before they become neurotrophic factor dependent, we have studied chick embryo nodose neurons, which have a particularly protracted period of neuorophic factor independence. Pharmacological reduction of intracellular free Ca2+ or deple...

journal_title：Neuron

authors： Larmet Y,Dolphin AC,Davies AM

更新日期：1992-09-01 00:00:00

abstract：:To discover new genes involved in axon navigation, we conducted a forward genetic screen for recessive alleles affecting motor neuron pathfinding in GFP reporter mice mutagenized with ENU. In Magellan mutant embryos, motor axons were error prone and wandered inefficiently at choice points within embryos, but paradoxic...

journal_title：Neuron

authors： Lewcock JW,Genoud N,Lettieri K,Pfaff SL

更新日期：2007-11-21 00:00:00

abstract：:The Neurodata Without Borders (NWB) initiative promotes data standardization in neuroscience to increase research reproducibility and opportunities. In the first NWB pilot project, neurophysiologists and software developers produced a common data format for recordings and metadata of cellular electrophysiology and opt...

journal_title：Neuron

authors： Teeters JL,Godfrey K,Young R,Dang C,Friedsam C,Wark B,Asari H,Peron S,Li N,Peyrache A,Denisov G,Siegle JH,Olsen SR,Martin C,Chun M,Tripathy S,Blanche TJ,Harris K,Buzsáki G,Koch C,Meister M,Svoboda K,Sommer FT

更新日期：2015-11-18 00:00:00

abstract：:The molecular pathways controlling cerebellar Purkinje cell dendrite formation and maturation are poorly understood. The Purkinje cell degeneration (pcd) mutant mouse is characterized by mutations in Nna1, a gene discovered in an axonal regenerative context, but whose actual function in development and disease is unkn...

journal_title：Neuron

authors： Li J,Gu X,Ma Y,Calicchio ML,Kong D,Teng YD,Yu L,Crain AM,Vartanian TK,Pasqualini R,Arap W,Libermann TA,Snyder EY,Sidman RL

更新日期：2010-10-06 00:00:00

abstract：:Cognitive maps are encoded in the hippocampal formation and related regions and range from the spatial to the purely conceptual. Neural mechanisms that encode information into relational structures, up to an arbitrary level of abstraction, may explain such a broad range of representation. Research now indicates that s...

journal_title：Neuron

authors： Schafer M,Schiller D

更新日期：2018-10-24 00:00:00

abstract：:Small G proteins are an extensive family of proteins that bind and hydrolyze GTP. They are ubiquitous inside cells, regulating a wide range of cellular processes. Recently, many studies have examined the role of small G proteins, particularly the Ras family of G proteins, in memory formation. Once thought to be primar...

journal_title：Neuron

authors： Ye X,Carew TJ

更新日期：2010-11-04 00:00:00

abstract：:The primary visual cortex has a map of multiple visual parameters whose topographic relations remain poorly understood. A new study (Nauhaus et al., 2016) reveals a nearly geometric map-topography that coexists within a remarkably precise representation of visual space. ...

journal_title：Neuron

authors： Alonso JM

更新日期：2016-08-17 00:00:00

abstract：:In this issue of Neuron, Viader et al. (2013) report on the production of toxic lipids by Schwann cells deficient in mitochondrial respiration, which are capable of destroying neighboring axons. This may have implications for understanding the neurobiology and treatment of mitochondrial neuropathies. ...

journal_title：Neuron

authors： Di Paolo G,Przedborski S

更新日期：2013-03-06 00:00:00

abstract：:Glucose-inhibited neurons orchestrate behavior and metabolism according to body energy levels, but how glucose inhibits these cells is unknown. We studied glucose inhibition of orexin/hypocretin neurons, which promote wakefulness (their loss causes narcolepsy) and also regulate metabolism and reward. Here we demonstra...

journal_title：Neuron

authors： Burdakov D,Jensen LT,Alexopoulos H,Williams RH,Fearon IM,O'Kelly I,Gerasimenko O,Fugger L,Verkhratsky A

更新日期：2006-06-01 00:00:00

abstract：:Small conductance Ca(2+)-activated K(+) (SK) channels and voltage-gated A-type Kv4 channels shape dendritic excitatory postsynaptic potentials (EPSPs) in hippocampal CA1 pyramidal neurons. Synaptically evoked Ca(2+) influx through N-methyl-D-aspartate receptors (NMDARs) activates spine SK channels, reducing EPSPs and ...

journal_title：Neuron

authors： Wang K,Lin MT,Adelman JP,Maylie J

更新日期：2014-01-22 00:00:00

abstract：:Structure-function studies have identified key functional motifs in the acetylcholine receptor, including residues that contribute to the ion channel and to the ligand-binding sites. Little is known, however, about determinants of channel gating kinetics. To identify structural correlates of gating, we examined the st...

journal_title：Neuron

authors： Bouzat C,Bren N,Sine SM

更新日期：1994-12-01 00:00:00