Abstract:
:Calcium/calmodulin kinase II (CaMKII) is required for LTP and experience-dependent potentiation in the barrel cortex. Here, we find that whisker deprivation increases LTP in the layer IV to II/III pathway and that PKA antagonists block the additional LTP. No LTP was seen in undeprived CaMKII-T286A mice, but whisker deprivation again unmasked PKA-sensitive LTP. Infusion of a PKA agonist potentiated EPSPs in deprived wild-types and deprived CaMKII-T286A point mutants but not in undeprived animals of either genotype. The PKA-dependent potentiation mechanism was not present in GluR1 knockouts. Infusion of a PKA antagonist caused depression of EPSPs in undeprived but not deprived cortex. LTD was occluded by whisker deprivation and blocked by PKA manipulation, but not blocked by cannabinoid antagonists. NMDA receptor currents were unaffected by sensory deprivation. These results suggest that sensory deprivation causes synaptic depression by reversing a PKA-dependent process that may act via GluR1.
journal_name
Neuronjournal_title
Neuronauthors
Hardingham N,Wright N,Dachtler J,Fox Kdoi
10.1016/j.neuron.2008.10.018subject
Has Abstractpub_date
2008-12-10 00:00:00pages
861-74issue
5eissn
0896-6273issn
1097-4199pii
S0896-6273(08)00891-Xjournal_volume
60pub_type
杂志文章相关文献
NEURON文献大全abstract::We used the cerebellum as a model to study the morphogenetic and cellular processes underlying the formation of elaborate brain structures from a simple neural tube, using an inducible genetic fate mapping approach in mouse. We demonstrate how a 90 degrees rotation between embryonic days 9 and 12 converts the rostral-...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2004.12.021
更新日期:2005-01-06 00:00:00
abstract::cGMP has long been suspected to play a role in synaptic plasticity, but the inaccessibility of nerve terminals to electrical recording has impeded tests of this hypothesis. In posterior pituitary nerve terminals, nitric oxide enhanced Ca(2+)-activated K+ channel activity by activating guanylate cyclase and PKG. This e...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(01)00449-4
更新日期:2001-09-27 00:00:00
abstract::Neuromodulators are important regulators of synaptic transmission throughout the brain. At the presynaptic terminal, neuromodulation of calcium channels (CaVs) can affect transmission not only by changing neurotransmitter release probability, but also by shaping short-term plasticity (STP). Indeed, changes in STP are ...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2018.07.030
更新日期:2018-09-05 00:00:00
abstract::Neuronal gain control is important for processing information in the brain. Shunting inhibition is not thought to control gain since it shifts input-output relationships during tonic excitation rather than changing their slope. Here we show that tonic inhibition reduces the gain and shifts the offset of cerebellar gra...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(03)00200-9
更新日期:2003-05-08 00:00:00
abstract::The ability of perisynaptic glial cells to modulate transmitter release and synaptic depression was studied at the frog neuromuscular junction (nmj). Injection of GTPgammaS in perisynaptic Schwann cells (PSCs), glial cells at this synapse, induced a reduction in the amplitude of nerve-evoked synaptic responses but had...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(00)80600-5
更新日期:1998-10-01 00:00:00
abstract::The N-methyl-D-aspartate (NMDA) subtype of glutamate receptor is important for synaptic plasticity and nervous system development and function. We have used genetic and electrophysiological methods to demonstrate that NMR-1, a Caenorhabditis elegans NMDA-type ionotropic glutamate receptor subunit, plays a role in the ...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(01)00394-4
更新日期:2001-08-30 00:00:00
abstract::The modulation of high voltage-activated (HVA) Ca2+ currents by L-glutamate and its agonists was investigated in cultured rat hypothalamic neurons. L-Glutamate and agonists selective for NMDA or non-NMDA receptors reversibly inhibited HVA Ca2+ currents. The putative presynaptic glutamate receptor agonist L-2-amino-4-p...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(93)90203-4
更新日期:1993-05-01 00:00:00
abstract::Recent work has suggested a link between h channels and epilepsy. In this issue of Neuron, Shah et al. demonstrate that a robust, postseizure decrease in h channels during a critical phase of epileptogenesis mechanistically underlies dendritic hyperexcitability in entorhinal-hippocampal pyramidal cells. ...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2004.10.018
更新日期:2004-10-28 00:00:00
abstract::We present evidence that synapse retraction occurs during normal synaptic growth at the Drosophila neuromuscular junction (NMJ). An RNAi-based screen to identify the molecular mechanisms that regulate synapse retraction identified Arp-1/centractin, a subunit of the dynactin complex. Arp-1 dsRNA enhances synapse retrac...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(02)00721-3
更新日期:2002-05-30 00:00:00
abstract::Ultrasound has received widespread attention as an emerging technology for targeted, non-invasive neuromodulation based on its ability to evoke electrophysiological and motor responses in animals. However, little is known about the spatiotemporal pattern of ultrasound-induced brain activity that could drive these resp...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2018.05.009
更新日期:2018-06-06 00:00:00
abstract::Embryonic mouse neural tubes produce a variety of terminally differentiated cells in vitro, mostly neurons and glia. We report here that some of these cells differentiate into skeletal muscle cells. The possibility of mesoderm contamination was ruled out as follows. First, Dil+ muscle cells were present in cultures fr...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(94)90248-8
更新日期:1994-10-01 00:00:00
abstract::The directional selectivity of retinal ganglion cell responses represents a primitive pattern recognition that operates within a retinal neural circuit. The cellular origin and mechanism of directional selectivity were investigated by selectively eliminating retinal starburst amacrine cells, using immunotoxin-mediated...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(01)00316-6
更新日期:2001-06-01 00:00:00
abstract::Local axon degeneration is a common pathological feature of many neurodegenerative diseases and peripheral neuropathies. While it is believed to operate with an apoptosis-independent molecular program, the underlying molecular mechanisms are largely unknown. In this study, we used the degeneration of transected axons,...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(03)00429-x
更新日期:2003-07-17 00:00:00
abstract::Using primary cultures and immortalized multipotential stem cell lines derived from wild-type and Mash1 mutant neural crest cells, we have analyzed the cellular function of MASH1 in autonomic neurogenesis. We present evidence for the existence of a precursor expressing MASH1 and neuronal markers such as neurofilament,...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(95)90005-5
更新日期:1995-12-01 00:00:00
abstract::A critical feature of neural networks is that they balance excitation and inhibition to prevent pathological dysfunction. How this is achieved is largely unknown, although deficits in the balance contribute to many neurological disorders. We show here that a microRNA (miR-101) is a key orchestrator of this essential f...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2016.11.017
更新日期:2016-12-21 00:00:00
abstract::Opiate analgesia, tolerance, and addiction are mediated by drug-induced activation of the mu opioid receptor. A fundamental question in addiction biology is why exogenous opiate drugs have a high liability for inducing tolerance and addiction while native ligands do not. Studies indicate that highly addictive opiate d...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(01)80032-5
更新日期:1999-08-01 00:00:00
abstract::Oxygen (O₂) and carbon dioxide (CO₂) levels vary in different environments and locally fluctuate during respiration and photosynthesis. Recent studies in diverse animals have identified sensory neurons that detect these external variations and direct a variety of behaviors. Detection allows animals to stay within a pr...
journal_title:Neuron
pub_type: 杂志文章,评审
doi:10.1016/j.neuron.2010.12.018
更新日期:2011-01-27 00:00:00
abstract::Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are age-related neurodegenerative disorders with shared genetic etiologies and overlapping clinical and pathological features. Here we studied a novel ALS/FTD family and identified the P362L mutation in the low-complexity domain (LCD) of T cell-rest...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2017.07.025
更新日期:2017-08-16 00:00:00
abstract::In recent years, nerve growth factor (NGF) has gained attention as a potential therapeutic agent for Alzheimer's disease (AD). To study the expression of NGF and its homologs, brain-derived neurotrophic factor (BDNF) and neurotrophin 3 (NT-3), postmortem samples of hippocampus from AD and control donors were examined ...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(91)90273-3
更新日期:1991-11-01 00:00:00
abstract::The dorsal anterior cingulate cortex (dACC) has a near-ubiquitous presence in the neuroscience of cognitive control. It has been implicated in a diversity of functions, from reward processing and performance monitoring to the execution of control and action selection. Here, we propose that this diversity can be unders...
journal_title:Neuron
pub_type: 杂志文章,评审
doi:10.1016/j.neuron.2013.07.007
更新日期:2013-07-24 00:00:00
abstract::The molecular pathways controlling cerebellar Purkinje cell dendrite formation and maturation are poorly understood. The Purkinje cell degeneration (pcd) mutant mouse is characterized by mutations in Nna1, a gene discovered in an axonal regenerative context, but whose actual function in development and disease is unkn...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2010.08.013
更新日期:2010-10-06 00:00:00
abstract::Clathrin-mediated endocytosis of synaptic vesicles requires molecular rearrangements of proteins as well as lipids. In this issue of Neuron, Schuske et al. and Verstreken et al. show that the lipid-modifying enzyme endophilin recruits and stabilizes the polyphosphoinositide phosphatase synaptojanin at nerve terminals....
journal_title:Neuron
pub_type: 评论,杂志文章,评审
doi:10.1016/s0896-6273(03)00726-8
更新日期:2003-11-13 00:00:00
abstract::Phorbol esters and purified protein kinase C (PKC) have been shown to down-modulate the voltage-dependent Na+ channels expressed in Xenopus oocytes injected with chick brain RNA. We used the two-electrode voltage-clamp technique to demonstrate that a Na+ channel expressed in oocytes injected with RNA coding for the al...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(91)90131-i
更新日期:1991-01-01 00:00:00
abstract::The performance of a task is often assumed to be a prerequisite for the learning of many tasks, including the associative conditioning of courtship in the fruit fly, Drosophila melanogaster. Transgenic flies specifically inhibited for the enzyme protein kinase C dissociate the acquisition of learning and memory from p...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(00)80270-6
更新日期:1997-02-01 00:00:00
abstract::Studies of the innervation of limb muscles by spinal motor neurons have helped to define mechanisms by which axons establish trajectories to their targets. Related motor axons select dorsal or ventral pathways at the base of the limb, raising the question of how these alternate trajectories are specified. EphA signali...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2008.11.011
更新日期:2008-12-26 00:00:00
abstract::Rho GTPases are essential regulators of cytoskeletal reorganization, but how they do so during neuronal morphogenesis in vivo is poorly understood. Here we show that the actin depolymerization factor cofilin is essential for axon growth in Drosophila neurons. Cofilin function in axon growth is inhibited by LIM kinase ...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2004.11.014
更新日期:2004-12-02 00:00:00
abstract::Experience-dependent plasticity in the adult brain has clinical potential for functional rehabilitation following central and peripheral nerve injuries. Here, plasticity induced by unilateral infraorbital (IO) nerve resection in 4-week-old rats was mapped using MRI and synaptic mechanisms were elucidated by slice elec...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2012.04.024
更新日期:2012-05-24 00:00:00
abstract::The biologically active photoproduct of rhodopsin, metarhodopsin II (M II), exists in a pH-sensitive equilibrium with its precursor, metarhodopsin I (M I). Increasing acidity favors M II, with the midpoint of the pH titration curve at pH 6.4. To test the long-standing proposal that histidine protonation regulates this...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(92)90274-h
更新日期:1992-03-01 00:00:00
abstract::Sensory systems transform the external world into time-varying spike trains. What features of spiking activity are used to guide behavior? In the mouse olfactory bulb, inhalation of different odors leads to changes in the set of neurons activated, as well as when neurons are activated relative to each other (synchrony...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2020.07.034
更新日期:2020-10-28 00:00:00
abstract::Neuroscientific findings are rarely translated into public policies that improve the health and well-being of people experiencing serious disorders. I advocate here for investment in policymaker-scientist networks dedicated to such translation for a range of diseases. ...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2019.08.016
更新日期:2019-09-25 00:00:00