Abstract:
:In recent years, nerve growth factor (NGF) has gained attention as a potential therapeutic agent for Alzheimer's disease (AD). To study the expression of NGF and its homologs, brain-derived neurotrophic factor (BDNF) and neurotrophin 3 (NT-3), postmortem samples of hippocampus from AD and control donors were examined by in situ hybridization. Hybridization signal for BDNF, but not NGF or NT-3, was decreased in samples of hippocampus from donors with AD. Decreased transcript abundance of BDNF mRNA in hippocampi of individuals with AD was verified by an RNAase protection assay. These results suggest the possibility that decreased expression of BDNF may contribute to the progression of cell death in AD.
journal_name
Neuronjournal_title
Neuronauthors
Phillips HS,Hains JM,Armanini M,Laramee GR,Johnson SA,Winslow JWdoi
10.1016/0896-6273(91)90273-3subject
Has Abstractpub_date
1991-11-01 00:00:00pages
695-702issue
5eissn
0896-6273issn
1097-4199pii
0896-6273(91)90273-3journal_volume
7pub_type
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