Abstract：
:The modulation of high voltage-activated (HVA) Ca2+ currents by L-glutamate and its agonists was investigated in cultured rat hypothalamic neurons. L-Glutamate and agonists selective for NMDA or non-NMDA receptors reversibly inhibited HVA Ca2+ currents. The putative presynaptic glutamate receptor agonist L-2-amino-4-phosphonobutyric acid and the selective metabotropic agonist trans-ACPD were ineffective. Inhibition was dependent on the presence of extracellular Ca2+ and blocked by internal perfusion of the cells with BAPTA. The calmodulin antagonists trifluoperazine and calmidazolium completely prevented the inhibition. Increases in the intracellular Ca2+ concentration due to Ca2+ influx through non-NMDA receptor channels were visualized using fura-2. These results indicate that not only NMDA but also non-NMDA receptor channels in these neurons are permeable for Ca2+ and that Ca2+ influx through these channels activates a calmodulin-dependent mechanism, which leads to HVA Ca2+ current inhibition.
journal_name
Neuronjournal_title
Neuronauthors
Zeilhofer HU,Müller TH,Swandulla Ddoi
10.1016/0896-6273(93)90203-4subject
Has Abstractpub_date
1993-05-01 00:00:00pages
879-87issue
5eissn
0896-6273issn
1097-4199pii
0896-6273(93)90203-4journal_volume
10pub_type
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