Dendritic h channelopathy in epileptogenesis.

abstract：:Little is known about genetic mechanisms that regulate the ratio of cortical excitatory and inhibitory neurons. We show that NPAS1 and NPAS3 transcription factors (TFs) are expressed in progenitor domains of the mouse basal ganglia (subpallium, MGE, and CGE). NPAS1(-/-) mutants had increased proliferation, ERK signali...

journal_title：Neuron

authors： Stanco A,Pla R,Vogt D,Chen Y,Mandal S,Walker J,Hunt RF,Lindtner S,Erdman CA,Pieper AA,Hamilton SP,Xu D,Baraban SC,Rubenstein JL

更新日期：2014-12-03 00:00:00

abstract：:The directional selectivity of retinal ganglion cell responses represents a primitive pattern recognition that operates within a retinal neural circuit. The cellular origin and mechanism of directional selectivity were investigated by selectively eliminating retinal starburst amacrine cells, using immunotoxin-mediated...

journal_title：Neuron

authors： Yoshida K,Watanabe D,Ishikane H,Tachibana M,Pastan I,Nakanishi S

更新日期：2001-06-01 00:00:00

abstract：:Primates can learn to recognize a virtually limitless number of visual objects. A candidate neural substrate for this adult plasticity is the inferior temporal cortex (ITC). Using a large stimulus set, we explored the impact that long-term experience has on the response properties of two classes of neurons in ITC: bro...

journal_title：Neuron

authors： Woloszyn L,Sheinberg DL

更新日期：2012-04-12 00:00:00

abstract：:The neurotrophin survival dependence of peripheral neurons in vitro is regulated by the proapoptotic BCL-2 homolog BAX. To study peripheral neuron development in the absence of neurotrophin signaling, we have generated mice that are double null for BAX and nerve growth factor (NGF), and BAX and the NGF receptor TrkA. ...

journal_title：Neuron

authors： Patel TD,Jackman A,Rice FL,Kucera J,Snider WD

更新日期：2000-02-01 00:00:00

abstract：:Attention or variations in event processing help drive learning. Lesion studies have implicated the central nucleus of the amygdala (CeA) in this process, particularly when expected rewards are omitted. However, lesion studies cannot specify how information processing in CeA supports such learning. To address these qu...

journal_title：Neuron

authors： Calu DJ,Roesch MR,Haney RZ,Holland PC,Schoenbaum G

更新日期：2010-12-09 00:00:00

abstract：:Homeostatic mechanisms stabilize neuronal activity in vivo, but whether this process gives rise to balanced network dynamics is unknown. Here, we continuously monitored the statistics of network spiking in visual cortical circuits in freely behaving rats for 9 days. Under control conditions in light and dark, networks...

journal_title：Neuron

authors： Ma Z,Turrigiano GG,Wessel R,Hengen KB

更新日期：2019-11-20 00:00:00

abstract：:Balance between excitation and inhibition (E-I balance) in neural circuits is believed to be tightly regulated. To the contrary, in this issue of Neuron, Bridi et al. (2020) reveal that inverse oscillations of synaptic inhibition and excitation lead to peaks and valleys in E-I balance across the 24 h day. ...

journal_title：Neuron

authors： Brunwasser SJ,Hengen KB

更新日期：2020-02-19 00:00:00

abstract：:FLRTs are broadly expressed proteins with the unique property of acting as homophilic cell adhesion molecules and as heterophilic repulsive ligands of Unc5/Netrin receptors. How these functions direct cell behavior and the molecular mechanisms involved remain largely unclear. Here we use X-ray crystallography to revea...

journal_title：Neuron

authors： Seiradake E,del Toro D,Nagel D,Cop F,Härtl R,Ruff T,Seyit-Bremer G,Harlos K,Border EC,Acker-Palmer A,Jones EY,Klein R

更新日期：2014-10-22 00:00:00

abstract：:Neuropeptides activate G protein-coupled receptors to acutely modulate cellular excitability and synaptic transmission. However, due to the lack of reagents for precise delivery of peptides within dense brain tissue, the spatiotemporal scale over which neuropeptides act is unknown. To achieve rapid and spatially delim...

journal_title：Neuron

authors： Banghart MR,Sabatini BL

更新日期：2012-01-26 00:00:00

abstract：:Although many studies have identified neural correlates of memory, relatively little is known about the circuit properties connecting single-neuron physiology to behavior. Here we developed a modeling framework to bridge this gap and identify circuit interactions capable of maintaining short-term memory. Unlike typica...

journal_title：Neuron

authors： Fisher D,Olasagasti I,Tank DW,Aksay ER,Goldman MS

更新日期：2013-09-04 00:00:00

abstract：:Perception of the thermal environment begins with the activation of peripheral thermosensory neurons innervating the body surface. To understand how temperature is represented in vivo, we used genetically encoded calcium indicators to measure temperature-evoked responses in hundreds of neurons across the trigeminal ga...

journal_title：Neuron

authors： Yarmolinsky DA,Peng Y,Pogorzala LA,Rutlin M,Hoon MA,Zuker CS

更新日期：2016-12-07 00:00:00

abstract：:Autism spectrum disorders (ASD) are a group of neurodevelopmental disorders with symptoms including social deficits, anxiety, and communication difficulties. However, ASD pathogenic mechanisms are poorly understood. Mutations of CUL3, which encodes Cullin 3 (CUL3), a component of an E3 ligase complex, are thought of a...

journal_title：Neuron

authors： Dong Z,Chen W,Chen C,Wang H,Cui W,Tan Z,Robinson H,Gao N,Luo B,Zhang L,Zhao K,Xiong WC,Mei L

更新日期：2020-02-05 00:00:00

abstract：:Elucidating the molecular mechanisms underlying quantitative neurocognitive phenotypes will further our understanding of the brain's structural and functional architecture and advance the diagnosis and treatment of the psychiatric disorders that these traits underlie. Although many neurocognitive traits are highly her...

journal_title：Neuron

authors： Congdon E,Poldrack RA,Freimer NB

更新日期：2010-10-21 00:00:00

abstract：:Asymmetric Ca(2+) elevations across the axonal growth cone mediate its turning responses to attractive and repulsive guidance cues. Here we show that clathrin-mediated endocytosis acts downstream of Ca(2+) signals as driving machinery for growth cone turning. In dorsal root ganglion neurons, the formation of clathrin-...

journal_title：Neuron

authors： Tojima T,Itofusa R,Kamiguchi H

更新日期：2010-05-13 00:00:00

abstract：:Molecular determinants of Ca2+ channel responsiveness to inhibition by receptor-coupled G proteins were investigated in Xenopus oocytes. The inhibitory response of alpha1B (N-type) channels was much larger than alpha1A (P/Q-type) channels, while alpha1C (L-type) channels were unresponsive. Differences in both degree a...

journal_title：Neuron

authors： Zhang JF,Ellinor PT,Aldrich RW,Tsien RW

更新日期：1996-11-01 00:00:00

abstract：:The mechanisms through which estrogen regulates gonadotropin-releasing hormone (GnRH) neurons to control mammalian ovulation are unknown. We found that estrogen positive feedback to generate the preovulatory gonadotropin surge was normal in estrogen receptor beta knockout (ERbeta) mutant mice, but absent in ERalpha mu...

journal_title：Neuron

authors： Wintermantel TM,Campbell RE,Porteous R,Bock D,Gröne HJ,Todman MG,Korach KS,Greiner E,Pérez CA,Schütz G,Herbison AE

更新日期：2006-10-19 00:00:00

abstract：:Slob is a novel protein that binds to the carboxy-terminal domain of the Drosophila Slowpoke (dSlo) calcium-dependent potassium (K(Ca)) channel. A yeast two-hybrid screen with Slob as bait identifies the zeta isoform of 14-3-3 as a Slob-binding protein. Coimmunoprecipitation experiments from Drosophila heads and trans...

journal_title：Neuron

authors： Zhou Y,Schopperle WM,Murrey H,Jaramillo A,Dagan D,Griffith LC,Levitan IB

更新日期：1999-04-01 00:00:00

abstract：:GABA, the major inhibitory neurotransmitter in the mammalian brain, binds to GABAA receptors, which form chloride ion channels. The predicted structure of the GABAA receptor places a consensus phosphorylation site for cAMP-dependent protein kinase (PKA) on an intracellular domain of the channel. Phosphorylation by var...

journal_title：Neuron

authors： Porter NM,Twyman RE,Uhler MD,Macdonald RL

更新日期：1990-12-01 00:00:00

abstract：:Small G proteins are an extensive family of proteins that bind and hydrolyze GTP. They are ubiquitous inside cells, regulating a wide range of cellular processes. Recently, many studies have examined the role of small G proteins, particularly the Ras family of G proteins, in memory formation. Once thought to be primar...

journal_title：Neuron

authors： Ye X,Carew TJ

更新日期：2010-11-04 00:00:00

abstract：:Particle-mediated gene transfer and two-photon microscopy were used to monitor the behavior of dendrites of individual cortical pyramidal neurons coexpressing green fluorescent protein (GFP) and brain-derived neurotrophic factor (BDNF). While the dendrites and spines of neurons expressing GFP alone grew modestly over ...

journal_title：Neuron

authors： Horch HW,Krüttgen A,Portbury SD,Katz LC

更新日期：1999-06-01 00:00:00

abstract：:Motion detection is a fundamental neural computation performed by many sensory systems. In the fly, local motion computation is thought to occur within the first two layers of the visual system, the lamina and medulla. We constructed specific genetic driver lines for each of the 12 neuron classes in the lamina. We the...

journal_title：Neuron

authors： Tuthill JC,Nern A,Holtz SL,Rubin GM,Reiser MB

更新日期：2013-07-10 00:00:00

abstract：:We have studied the expression of NGF receptor (NGFR) mRNA in the mouse trigeminal system at closely staged intervals throughout development. The level of NGFR mRNA per neuron is at a constant low level before the earliest axons reach the target field and increases 5-fold to plateau shortly after the arrival of the la...

journal_title：Neuron

authors： Wyatt S,Shooter EM,Davies AM

更新日期：1990-03-01 00:00:00

abstract：:Animals must discern important stimuli and place them onto their cognitive map of their environment. The neocortex conveys general representations of sensory events to the hippocampus, and the hippocampus is thought to classify and sharpen the distinctions between these events. We recorded populations of dentate gyrus...

journal_title：Neuron

authors： Woods NI,Stefanini F,Apodaca-Montano DL,Tan IMC,Biane JS,Kheirbek MA

更新日期：2020-07-08 00:00:00

abstract：:We review the central tenets and neuroanatomical basis of the global neuronal workspace (GNW) hypothesis, which attempts to account for the main scientific observations regarding the elementary mechanisms of conscious processing in the human brain. The GNW hypothesis proposes that, in the conscious state, a non-linear...

journal_title：Neuron

authors： Mashour GA,Roelfsema P,Changeux JP,Dehaene S

更新日期：2020-03-04 00:00:00

abstract：:Screens for genes that orchestrate neural circuit formation in mammals have been hindered by practical constraints of germline mutagenesis. To overcome these limitations, we combined RNA-seq with somatic CRISPR mutagenesis to study synapse development in the mouse retina. Here synapses occur between cellular layers, f...

journal_title：Neuron

authors： Sarin S,Zuniga-Sanchez E,Kurmangaliyev YZ,Cousins H,Patel M,Hernandez J,Zhang KX,Samuel MA,Morey M,Sanes JR,Zipursky SL

更新日期：2018-04-04 00:00:00

abstract：:In this issue of Neuron, Royal et al. (2018) find that a mutant form of the TRESK ion channel linked to migraine undergoes alternative translation to produce an inhibitory protein that blocks TREK channels, leading to neuronal hyperexcitability and migraine in rodents. ...

journal_title：Neuron

authors： Hill RZ,Bautista DM

更新日期：2019-01-16 00:00:00

abstract：:The local field potential (LFP) reflects activity of many neurons in the vicinity of the recording electrode and is therefore useful for studying local network dynamics. Much of the nature of the LFP is, however, still unknown. There are, for instance, contradicting reports on the spatial extent of the region generati...

journal_title：Neuron

authors： Lindén H,Tetzlaff T,Potjans TC,Pettersen KH,Grün S,Diesmann M,Einevoll GT

更新日期：2011-12-08 00:00:00

abstract：:The Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway is involved in many cellular processes, including cell growth and differentiation, immune functions and cancer. It is activated by various cytokines, growth factors, and protein tyrosine kinases (PTKs) and regulates the transcriptio...

journal_title：Neuron

authors： Nicolas CS,Peineau S,Amici M,Csaba Z,Fafouri A,Javalet C,Collett VJ,Hildebrandt L,Seaton G,Choi SL,Sim SE,Bradley C,Lee K,Zhuo M,Kaang BK,Gressens P,Dournaud P,Fitzjohn SM,Bortolotto ZA,Cho K,Collingridge GL

更新日期：2012-01-26 00:00:00

abstract：:Sensory systems transform the external world into time-varying spike trains. What features of spiking activity are used to guide behavior? In the mouse olfactory bulb, inhalation of different odors leads to changes in the set of neurons activated, as well as when neurons are activated relative to each other (synchrony...

journal_title：Neuron

authors： Gill JV,Lerman GM,Zhao H,Stetler BJ,Rinberg D,Shoham S

更新日期：2020-10-28 00:00:00

abstract：:Microglia are the immune cells of the brain. Here we show a massive infiltration of highly ramified and elongated microglia within the core of amyloid plaques in transgenic mouse models of Alzheimer's disease (AD). Many of these cells originate from the bone marrow, and the beta-amyloid-40 and -42 isoforms are able to...

journal_title：Neuron

authors： Simard AR,Soulet D,Gowing G,Julien JP,Rivest S

更新日期：2006-02-16 00:00:00