Precise Holographic Manipulation of Olfactory Circuits Reveals Coding Features Determining Perceptual Detection.

abstract：:Perception of the thermal environment begins with the activation of peripheral thermosensory neurons innervating the body surface. To understand how temperature is represented in vivo, we used genetically encoded calcium indicators to measure temperature-evoked responses in hundreds of neurons across the trigeminal ga...

journal_title：Neuron

authors： Yarmolinsky DA,Peng Y,Pogorzala LA,Rutlin M,Hoon MA,Zuker CS

更新日期：2016-12-07 00:00:00

abstract：:Nociceptive terminals possess the elements for detecting, transmitting, and modulating noxious signals, thus being pivotal for pain sensation. Despite this, a functional description of the transduction process by the terminals, in physiological conditions, has not been fully achieved. Here, we studied how nociceptive ...

journal_title：Neuron

authors： Goldstein RH,Barkai O,Íñigo-Portugués A,Katz B,Lev S,Binshtok AM

更新日期：2019-05-22 00:00:00

abstract：:Homeostatic signaling systems are thought to interface with the mechanisms of neural plasticity to achieve stable yet flexible neural circuitry. However, the time course, molecular design, and implementation of homeostatic signaling remain poorly defined. Here we demonstrate that a homeostatic increase in presynaptic ...

journal_title：Neuron

authors： Frank CA,Kennedy MJ,Goold CP,Marek KW,Davis GW

更新日期：2006-11-22 00:00:00

abstract：:The constant dynamic movement of synapses and their components has emerged in the last decades as a key feature of synaptic transmission and its plasticity. Intramolecular protein movements drive conformation changes important to transduce transmitter binding into signaling. Constant cytoskeletal rearrangements power ...

journal_title：Neuron

authors： Choquet D,Triller A

更新日期：2013-10-30 00:00:00

abstract：:Telling time and anticipating when external events will happen is among the most important tasks the brain performs. Yet the neural mechanisms underlying timing remain elusive. One theory proposes that timing is a general and intrinsic computation of cortical circuits. We tested this hypothesis using electrical and op...

journal_title：Neuron

authors： Goel A,Buonomano DV

更新日期：2016-07-20 00:00:00

abstract：:Vaccinia virus can be used to infect cells in the CNS of frogs, Xenopus laevis, and Rana pipiens, both in vivo and in vitro. In vivo infections were accomplished by injection of viral solution into the tectal ventricle of stage 40-48 tadpoles or by local injections into distinct neural regions. Infections with high ti...

journal_title：Neuron

authors： Wu GY,Zou DJ,Koothan T,Cline HT

更新日期：1995-04-01 00:00:00

abstract：:Recently, we found that electrical stimulation of motor cortex caused monkeys to make coordinated, complex movements. These evoked movements were arranged across the cortex in a map of spatial locations to which the hand moved. We suggest that some of the subdivisions previously described within primary motor and prem...

journal_title：Neuron

authors： Graziano MS,Taylor CS,Moore T,Cooke DF

更新日期：2002-10-24 00:00:00

abstract：:Changes in social preference of amphibian larvae result from sustained exposure to kinship odorants. To understand the molecular and cellular mechanisms of this neuroplasticity, we investigated the effects of olfactory system activation on neurotransmitter (NT) expression in accessory olfactory bulb (AOB) interneurons...

journal_title：Neuron

authors： Dulcis D,Lippi G,Stark CJ,Do LH,Berg DK,Spitzer NC

更新日期：2017-09-13 00:00:00

abstract：:Migraine is thought to be triggered by excessive neocortical neuronal excitability that leads to cortical spreading depression. In this issue of Neuron, Tottene et al. study a mouse model of familial hemiplegic migraine type 1, and provide evidence for the hyperactivity of P/Q-type calcium channel-mediated cortical gl...

journal_title：Neuron

authors： Xue M,Rosenmund C

更新日期：2009-03-12 00:00:00

abstract：:People often perceive configurations rather than the elements they comprise, a bias that may emerge because configurations often predict outcomes. But how does the brain learn to associate configurations with outcomes and how does this learning differ from learning about individual elements? We combined behavior, rein...

journal_title：Neuron

authors： Duncan K,Doll BB,Daw ND,Shohamy D

更新日期：2018-05-02 00:00:00

abstract：:Spinal cord axons display a rostrocaudal, positional bias in their innervation of sympathetic ganglia and intercostal skeletal muscles. In an effort to examine the molecular basis of this positional specificity, we used the cyclophosphamide immunosuppression method to produce monoclonal antibodies that bind preferenti...

journal_title：Neuron

authors： Suzue T,Kaprielian Z,Patterson PH

更新日期：1990-10-01 00:00:00

abstract：:We recently proposed that ciliary neurotrophic factor (CNTF) shares two receptor components with a generally acting cytokine, leukemia inhibitory factor (LIF), but that CNTF also requires a third receptor component (CNTFR alpha) that is mostly restricted to the nervous system in its expression. Here we demonstrate tha...

journal_title：Neuron

authors： Ip NY,McClain J,Barrezueta NX,Aldrich TH,Pan L,Li Y,Wiegand SJ,Friedman B,Davis S,Yancopoulos GD

更新日期：1993-01-01 00:00:00

abstract：:Examining the behavioral consequences of selective CNS neuronal activation is a powerful tool for elucidating mammalian brain function in health and disease. Newly developed genetic, pharmacological, and optical tools allow activation of neurons with exquisite spatiotemporal resolution; however, the inaccessibility to...

journal_title：Neuron

authors： Alexander GM,Rogan SC,Abbas AI,Armbruster BN,Pei Y,Allen JA,Nonneman RJ,Hartmann J,Moy SS,Nicolelis MA,McNamara JO,Roth BL

更新日期：2009-07-16 00:00:00

abstract：:The establishment of axon-dendrite polarity is fundamental for radial migration of neurons during cortex development of mammals. We demonstrate that the E3 ubiquitin ligases WW-Containing Proteins 1 and 2 (Wwp1 and Wwp2) are indispensable for proper polarization of developing neurons. We show that knockout of Wwp1 and...

journal_title：Neuron

authors： Ambrozkiewicz MC,Schwark M,Kishimoto-Suga M,Borisova E,Hori K,Salazar-Lázaro A,Rusanova A,Altas B,Piepkorn L,Bessa P,Schaub T,Zhang X,Rabe T,Ripamonti S,Rosário M,Akiyama H,Jahn O,Kobayashi T,Hoshino M,Tarabykin V,

更新日期：2018-12-05 00:00:00

abstract：:We describe the isolation and characterization of a cDNA encoding the alpha subunit of a new voltage-sensitive sodium channel, microI, from rat skeletal muscle. The 1840 amino acid microI peptide is homologous to alpha subunits from rat brain, but, like the protein from eel electroplax, lacks an extended (approximatel...

journal_title：Neuron

authors： Trimmer JS,Cooperman SS,Tomiko SA,Zhou JY,Crean SM,Boyle MB,Kallen RG,Sheng ZH,Barchi RL,Sigworth FJ

更新日期：1989-07-01 00:00:00

abstract：:Many excitatory synapses express Group 1, or Gq coupled, metabotropic glutamate receptors (Gp1 mGluRs) at the periphery of their postsynaptic density. Activation of Gp1 mGluRs typically occurs in response to strong activity and triggers long-term plasticity of synaptic transmission in many brain regions, including the...

journal_title：Neuron

authors： Lüscher C,Huber KM

更新日期：2010-02-25 00:00:00

abstract：:Cognitive control is subjectively costly, suggesting that engagement is modulated in relationship to incentive state. Dopamine appears to play key roles. In particular, dopamine may mediate cognitive effort by two broad classes of functions: (1) modulating the functional parameters of working memory circuits subservin...

journal_title：Neuron

authors： Westbrook A,Braver TS

更新日期：2016-02-17 00:00:00

abstract：:Simultaneous whole-cell recordings were made from the soma and dendrites of cerebellar Purkinje cells in rat brain slices. Sodium action potentials, evoked by either depolarizing current pulses or synaptic stimulation of parallel or climbing fibers, always occurred first at the soma and decreased in amplitude with inc...

journal_title：Neuron

authors： Stuart G,Häusser M

更新日期：1994-09-01 00:00:00

abstract：:Both the nucleus accumbens (NAc) and basolateral amygdala (BLA) contribute to learned behavioral choice. Neurons in both structures that encode reward-predictive cues may underlie the decision to respond to such cues, but the neural circuits by which the BLA influences reward-seeking behavior have not been established...

journal_title：Neuron

authors： Ambroggi F,Ishikawa A,Fields HL,Nicola SM

更新日期：2008-08-28 00:00:00

abstract：:The auditory cortex encodes information about sounds through the combined activity of large numbers of neurons, but the way this population activity is organized has not been clear. In this issue of Neuron, Bathellier et al. (2012) show that firing in the superficial layers of auditory cortex is organized into a small...

journal_title：Neuron

authors： Harris KD

更新日期：2012-10-18 00:00:00

abstract：:alpha-Latrotoxin is a potent stimulator of neurosecretion. Its action requires extracellular binding to high affinity presynaptic receptors. Neurexin I alpha was previously described as a high affinity alpha-latrotoxin receptor that binds the toxin only in the presence of calcium ions. Therefore, the interaction of al...

journal_title：Neuron

authors： Krasnoperov VG,Bittner MA,Beavis R,Kuang Y,Salnikow KV,Chepurny OG,Little AR,Plotnikov AN,Wu D,Holz RW,Petrenko AG

更新日期：1997-06-01 00:00:00

abstract：:Both acute and chronic changes in AMPA receptor (AMPAR) localization are critical for synaptic formation, maturation, and plasticity. Here I report that AMPARs are differentially sorted between recycling and degradative pathways following endocytosis. AMPAR sorting occurs in early endosomes and is regulated by synapti...

journal_title：Neuron

authors： Ehlers MD

更新日期：2000-11-01 00:00:00

abstract：:Forming long-term memory (LTM) often requires repetitive experience spread over time. Studies in Drosophila suggest aversive olfactory LTM is optimal after spaced training, multiple trials of differential odor conditioning with rest intervals. Memory after spaced training is frequently compared to that after the same ...

journal_title：Neuron

authors： Jacob PF,Waddell S

更新日期：2020-06-17 00:00:00

abstract：:Quantitative differences in cadherin activity have been proposed to play important roles in patterning connections between pre- and postsynaptic neurons. However, no examples of such a function have yet been described, and the mechanisms that would allow such differences to direct growth cones to specific synaptic tar...

journal_title：Neuron

authors： Chen PL,Clandinin TR

更新日期：2008-04-10 00:00:00

abstract：:The blood-brain barrier (BBB) poses a major challenge for developing effective antibody therapies for neurological diseases. Using transcriptomic and proteomic profiling, we searched for proteins in mouse brain endothelial cells (BECs) that could potentially be exploited to transport antibodies across the BBB. Due to ...

journal_title：Neuron

authors： Zuchero YJ,Chen X,Bien-Ly N,Bumbaca D,Tong RK,Gao X,Zhang S,Hoyte K,Luk W,Huntley MA,Phu L,Tan C,Kallop D,Weimer RM,Lu Y,Kirkpatrick DS,Ernst JA,Chih B,Dennis MS,Watts RJ

更新日期：2016-01-06 00:00:00

abstract：:The development and homeostasis of neurons relies heavily on the selective targeting of vesicles into axon and dendrites. Microtubule-based motor proteins play an important role in polarized transport; however, the sorting mechanism to exclude dendritic cargo from the axon is unclear. We show that the dynein regulator...

journal_title：Neuron

authors： Kuijpers M,van de Willige D,Freal A,Chazeau A,Franker MA,Hofenk J,Rodrigues RJ,Kapitein LC,Akhmanova A,Jaarsma D,Hoogenraad CC

更新日期：2016-02-03 00:00:00

abstract：:To achieve simultaneous measurement of multiple cellular events in molecularly defined groups of neurons in vivo, we designed a spectrometer-based fiber photometry system that allows for spectral unmixing of multiple fluorescence signals recorded from deep brain structures in behaving animals. Using green and red Ca2+...

journal_title：Neuron

authors： Meng C,Zhou J,Papaneri A,Peddada T,Xu K,Cui G

更新日期：2018-05-16 00:00:00

abstract：:The maturation of synaptic structures depends on inductive interactions between axons and their prospective targets. One example of such an interaction is the influence of proprioceptive sensory axons on the differentiation of muscle spindles. We have monitored the expression of three transcription factors, Egr3, Pea3...

journal_title：Neuron

authors： Hippenmeyer S,Shneider NA,Birchmeier C,Burden SJ,Jessell TM,Arber S

更新日期：2002-12-19 00:00:00

abstract：:Under ambient air conditions, NO inhibits NMDAR activity by reacting with the NR2A subunit C399 along with two additional cysteine pairs if their disulfide bonds are reduced to free thiol groups [NR1(C744,C798); NR2(C87,C320)]. Here we demonstrate that relative hypoxia enhances S-nitrosylation of NMDARs by a unique me...

journal_title：Neuron

authors： Takahashi H,Shin Y,Cho SJ,Zago WM,Nakamura T,Gu Z,Ma Y,Furukawa H,Liddington R,Zhang D,Tong G,Chen HS,Lipton SA

更新日期：2007-01-04 00:00:00

abstract：:The hippocampal CA2 subregion has a different anatomical connectivity pattern within the entorhino-hippocampal circuit than either the CA1 or CA3 subregion. Yet major differences in the neuronal activity patterns of CA2 compared with the other CA subregions have not been reported. We show that standard spatial and tem...

journal_title：Neuron

authors： Mankin EA,Diehl GW,Sparks FT,Leutgeb S,Leutgeb JK

更新日期：2015-01-07 00:00:00