Abstract：
:People often perceive configurations rather than the elements they comprise, a bias that may emerge because configurations often predict outcomes. But how does the brain learn to associate configurations with outcomes and how does this learning differ from learning about individual elements? We combined behavior, reinforcement learning models, and functional imaging to understand how people learn to associate configurations of cues with outcomes. We found that configural learning depended on the relative predictive strength of elements versus configurations and was related to both the strength of BOLD activity and patterns of BOLD activity in the hippocampus. Configural learning was further related to functional connectivity between the hippocampus and nucleus accumbens. Moreover, configural learning was associated with flexible knowledge about associations and differential eye movements during choice. Together, this suggests that configural learning is associated with a distinct computational, cognitive, and neural profile that is well suited to support flexible and adaptive behavior.
journal_name
Neuronjournal_title
Neuronauthors
Duncan K,Doll BB,Daw ND,Shohamy Ddoi
10.1016/j.neuron.2018.03.042subject
Has Abstractpub_date
2018-05-02 00:00:00pages
645-657.e6issue
3eissn
0896-6273issn
1097-4199pii
S0896-6273(18)30248-4journal_volume
98pub_type
杂志文章相关文献
NEURON文献大全abstract：:Disruption of one allele of the LIS1 gene causes a severe developmental brain abnormality, type I lissencephaly. In Aspergillus nidulans, the LIS1 homolog, NUDF, and cytoplasmic dynein are genetically linked and regulate nuclear movements during hyphal growth. Recently, we demonstrated that mammalian LIS1 regulates dy...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/s0896-6273(00)00147-1
更新日期：2000-12-01 00:00:00
abstract：:Backpropagating action potentials (bAPs) are an important signal for associative synaptic plasticity in many neurons, but they often fail to fully invade distal dendrites. In this issue of Neuron, Sjöström and Häusser show that distal propagation failure leads to a spatial gradient of Hebbian plasticity in neocortical...
journal_title：Neuron
pub_type： 评论,杂志文章,评审
doi：10.1016/j.neuron.2006.07.003
更新日期：2006-07-20 00:00:00
abstract：:Feeding is dynamically regulated by the palatability of the food source and the physiological needs of the animal. How consumption is controlled by external sensory cues and internal metabolic state remains under intense investigation. Here, we identify four GABAergic interneurons in the Drosophila brain that establis...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2014.05.006
更新日期：2014-07-02 00:00:00
abstract：:We generated transgenic mice that specifically express foreign genes in myelinating Schwann cells. A 1.1 kb segment of 5' flanking sequence from the rat P0 gene was used to drive expression of the genes encoding human growth hormone (hGH) and bacterial diphtheria toxin A chain (DT-A). The P0-hGH mice expressed hGH in ...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/0896-6273(92)90279-m
更新日期：1992-03-01 00:00:00
abstract：:Synapses have a limited pool of vesicles that are docked and primed for rapid release. In neuroendocrine cells, splice variants of the SNARE protein SNAP-25 and phosphorylation of SNAP-25 independently influence the size of the releasable vesicle pool, possibly by altering the rate of vesicle depriming. Pre- and postt...
journal_title：Neuron
pub_type： 评论,杂志文章
doi：10.1016/s0896-6273(04)00039-x
更新日期：2004-02-05 00:00:00
abstract：:Brief depolarization of cerebellar Purkinje cells was found to inhibit parallel fiber and climbing fiber EPSCs for tens of seconds. This depolarization-induced suppression of excitation (DSE) is accompanied by altered paired-pulse plasticity, suggesting a presynaptic locus. Fluorometric imaging revealed that postsynap...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/s0896-6273(01)00246-x
更新日期：2001-03-01 00:00:00
abstract：:Ca(2+)-calmodulin (CaM) function was selectively disrupted in a specific subset of growth cones in transgenic Drosophila embryos in which a specific enhancer element drives the expression of the kinesin motor domain fused to a CaM antagonist peptide (kinesin-antagonist or KA, which blocks CaM binding to target protein...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/0896-6273(95)90239-2
更新日期：1995-01-01 00:00:00
abstract：:Primary familial brain calcification (PFBC) is a genetically heterogeneous disorder characterized by bilateral calcifications in the basal ganglia and other brain regions. The genetic basis of this disorder remains unknown in a significant portion of familial cases. Here, we reported a recessive causal gene, MYORG, fo...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2018.05.037
更新日期：2018-06-27 00:00:00
abstract：:The visual perception of words is known to activate the auditory representation of their spoken forms automatically. We examined the neural mechanism for this phonological activation using transcranial magnetic stimulation (TMS) with a masked priming paradigm. The stimulation sites (left superior temporal gyrus [L-STG...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2006.09.030
更新日期：2006-11-09 00:00:00
abstract：:Neural crest cells of vertebrate embryos produce neurons, glia, pigment cells, and connective tissue in vivo and in vitro. To test the developmental potential of apparently undifferentiated crest cells, we have used the monoclonal antibody A2B5, which recognizes a cell surface glycolipid characteristic of neurons, to ...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/0896-6273(88)90106-7
更新日期：1988-09-01 00:00:00
abstract：:By using a tau construct with two mimicked acetylation sites as identified in AD brains, Tracy et al. (2016) found that acetylated tau promotes synaptic dysfunction through disruption of postsynaptic KIBRA signaling pathways, actin dynamics, and AMPA receptor trafficking. ...
journal_title：Neuron
pub_type： 评论,杂志文章
doi：10.1016/j.neuron.2016.04.008
更新日期：2016-04-20 00:00:00
abstract：:S-Nitrosylation is a redox-mediated posttranslational modification that regulates protein function via covalent reaction of nitric oxide (NO)-related species with a cysteine thiol group on the target protein. Under physiological conditions, S-nitrosylation can be an important modulator of signal transduction pathways,...
journal_title：Neuron
pub_type： 杂志文章,评审
doi：10.1016/j.neuron.2013.05.005
更新日期：2013-05-22 00:00:00
abstract：:Synaptic transmission is bioenergetically demanding, and the diverse processes underlying synaptic plasticity elevate these demands. Therefore, mitochondrial functions, including ATP synthesis and Ca2+ handling, are likely essential for plasticity. Although axonal mitochondria have been extensively analyzed, LTP is pr...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2018.09.025
更新日期：2018-11-21 00:00:00
abstract：:In this issue of Neuron, Kupferschmidt et al. (2017) reveal the shifting dynamics of functionally defined corticostriatal pathways during skill learning in mice using fiber photometry. They show different time courses in plasticity of associative and sensorimotor circuits across learning that involve changes at both t...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2017.09.046
更新日期：2017-10-11 00:00:00
abstract：:The mechanisms that constrain memory formation are of special interest because they provide insights into the brain's memory management systems and potential avenues for correcting cognitive disorders. RNAi knockdown in the Drosophila mushroom body neurons (MBn) of a newly discovered memory suppressor gene, Solute Car...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2016.03.017
更新日期：2016-05-04 00:00:00
abstract：:Given that cocaine induces neuroadaptations through regulation of gene expression, we investigated whether chromatin remodeling at specific gene promoters may be a key mechanism. We show that cocaine induces specific histone modifications at different gene promoters in striatum, a major neural substrate for cocaine's ...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2005.09.023
更新日期：2005-10-20 00:00:00
abstract：:Slob is a novel protein that binds to the carboxy-terminal domain of the Drosophila Slowpoke (dSlo) calcium-dependent potassium (K(Ca)) channel. A yeast two-hybrid screen with Slob as bait identifies the zeta isoform of 14-3-3 as a Slob-binding protein. Coimmunoprecipitation experiments from Drosophila heads and trans...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/s0896-6273(00)80739-4
更新日期：1999-04-01 00:00:00
abstract：:Recent work has suggested a link between h channels and epilepsy. In this issue of Neuron, Shah et al. demonstrate that a robust, postseizure decrease in h channels during a critical phase of epileptogenesis mechanistically underlies dendritic hyperexcitability in entorhinal-hippocampal pyramidal cells. ...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2004.10.018
更新日期：2004-10-28 00:00:00
abstract：:Habits are notoriously difficult to break and, if broken, are usually replaced by new routines. To examine the neural basis of these characteristics, we recorded spike activity in cortical and striatal habit sites as rats learned maze tasks. Overtraining induced a shift from purposeful to habitual behavior. This shift...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2013.05.038
更新日期：2013-07-24 00:00:00
abstract：:The process by which neural circuitry in the brain plans and executes movements is not well understood. Until recently, most available data were limited either to single-neuron electrophysiological recordings or to measures of aggregate field or metabolism. Neither approach reveals how individual neurons' activities a...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2011.05.047
更新日期：2011-08-11 00:00:00
abstract：:The retinal pigment epithelium (RPE) plays an essential role in the normal development of the underlying neural retina, but the mechanisms by which this regulation occurs are largely unknown. Ca2+ transients, induced by the neurotransmitter ATP acting on purinergic receptors, both increase proliferation and stimulate ...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2005.04.024
更新日期：2005-06-02 00:00:00
abstract：:The behavioral expression of fear ranges from active, cognitive responses to passive, freezing-like reactions. In this issue of Neuron, Gozzi, Jain, and colleagues suggest that neurons in the central amygdala orchestrate output signals toward either the brainstem or cholinergic basal forebrain and thereby can shift fe...
journal_title：Neuron
pub_type： 评论,杂志文章
doi：10.1016/j.neuron.2010.08.009
更新日期：2010-08-26 00:00:00
abstract：:In order to deal effectively with danger, it is imperative to know about it. This is what nociceptors do--these primary sensory neurons are specialized to detect intense stimuli and represent, therefore, the first line of defense against any potentially threatening or damaging environmental inputs. By sensing noxious ...
journal_title：Neuron
pub_type： 杂志文章,评审
doi：10.1016/j.neuron.2007.07.016
更新日期：2007-08-02 00:00:00
abstract：:In this issue of Neuron, Holz et al. (2019) show that the synaptic protein Homer1a switches mGluR5 signaling to increase AMPA receptor activity for the rapid antidepressant actions of sleep deprivation. ...
journal_title：Neuron
pub_type： 评论,杂志文章
doi：10.1016/j.neuron.2019.10.003
更新日期：2019-10-23 00:00:00
abstract：:NMDA receptor subunit composition varies throughout the brain, providing molecular diversity in NMDA receptor function. The NR2 subunits (NR2A-D) in large part dictate the distinct functional properties of NMDA receptors and differentially regulate receptor trafficking. Although the NR2C subunit is highly enriched in ...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2009.04.015
更新日期：2009-05-28 00:00:00
abstract：:Degeneration of basal forebrain cholinergic neurons (BFCNs) contributes to cognitive dysfunction in Alzheimer's disease (AD) and Down's syndrome (DS). We used Ts65Dn and Ts1Cje mouse models of DS to show that the increased dose of the amyloid precursor protein gene, App, acts to markedly decrease NGF retrograde transp...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2006.05.022
更新日期：2006-07-06 00:00:00
abstract：:The Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway is involved in many cellular processes, including cell growth and differentiation, immune functions and cancer. It is activated by various cytokines, growth factors, and protein tyrosine kinases (PTKs) and regulates the transcriptio...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2011.11.024
更新日期：2012-01-26 00:00:00
abstract：:How do neurons develop, control, and maintain their electrical signaling properties in spite of ongoing protein turnover and perturbations to activity? From generic assumptions about the molecular biology underlying channel expression, we derive a simple model and show how it encodes an "activity set point" in single ...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2014.04.002
更新日期：2014-05-21 00:00:00
abstract：:The state of the brain and body constantly varies on rapid and slow timescales. These variations contribute to the apparent noisiness of sensory responses at both the neural and the behavioral level. Recent investigations of rapid state changes in awake, behaving animals have provided insight into the mechanisms by wh...
journal_title：Neuron
pub_type： 杂志文章,评审
doi：10.1016/j.neuron.2015.09.012
更新日期：2015-09-23 00:00:00
abstract：:Vesicular transporters are required for the storage of all classical and amino acid neurotransmitters in synaptic vesicles. Some neurons lack known vesicular transporters, suggesting additional neurotransmitter systems remain unidentified. Insect mushroom bodies (MBs) are critical for several behaviors, including lear...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2011.08.032
更新日期：2011-10-20 00:00:00
