The Jak/STAT pathway is involved in synaptic plasticity.

abstract：:It is widely believed that the brain performs approximate probabilistic inference to estimate causal variables in the world from ambiguous sensory data. To understand these computations, we need to analyze how information is represented and transformed by the actions of nonlinear recurrent neural networks. We propose ...

journal_title：Neuron

authors： Pitkow X,Angelaki DE

更新日期：2017-06-07 00:00:00

abstract：:Two types of ryanodine receptors, channels for Ca2+ release from intracellular stores, are known. We detected the skeletal muscle type only in cerebellum by immunoblot analysis of microsomes and partially purified proteins. The cardiac muscle type was found in all parts of the mouse brain. Immunohistochemical study sh...

journal_title：Neuron

authors： Kuwajima G,Futatsugi A,Niinobe M,Nakanishi S,Mikoshiba K

更新日期：1992-12-01 00:00:00

abstract：:Inhibitory neurons, which play a critical role in decision-making models, are often simplified as a single pool of non-selective neurons lacking connection specificity. This assumption is supported by observations in the primary visual cortex: inhibitory neurons are broadly tuned in vivo and show non-specific connecti...

journal_title：Neuron

authors： Najafi F,Elsayed GF,Cao R,Pnevmatikakis E,Latham PE,Cunningham JP,Churchland AK

更新日期：2020-01-08 00:00:00

abstract：:Serotonergic neurons are thought to play a role in depression and obsessive compulsive disorder. However, their functional transmitter repertoire is incompletely known. To investigate this repertoire, intracellular recordings were obtained from 132 cytochemically identified rat mesopontine serotonergic neurons that ha...

journal_title：Neuron

authors： Johnson MD

更新日期：1994-02-01 00:00:00

abstract：:A fundamental property of neuronal circuits is the ability to adapt to altered sensory inputs. It is well established that the functional synaptic changes underlying this adaptation are reflected by structural modifications in excitatory neurons. In contrast, the degree to which structural plasticity in inhibitory neu...

journal_title：Neuron

authors： Keck T,Scheuss V,Jacobsen RI,Wierenga CJ,Eysel UT,Bonhoeffer T,Hübener M

更新日期：2011-09-08 00:00:00

abstract：:Acute gene inactivation using short hairpin RNA (shRNA, knockdown) in developing brain is a powerful technique to study genetic function; however, discrepancies between knockdown and knockout murine phenotypes have left unanswered questions. For example, doublecortin (Dcx) knockdown but not knockout shows a neocortica...

journal_title：Neuron

authors： Baek ST,Kerjan G,Bielas SL,Lee JE,Fenstermaker AG,Novarino G,Gleeson JG

更新日期：2014-06-18 00:00:00

abstract：:It has been hypothesized that the direction of synaptic weight change elicited by synaptic activity depends on the magnitude of the activity-dependent rise in intracellular Ca2+ concentration. Several aspects of this hypothesis were examined at the Schaffer collateral CA1 synapse, where both long-term depression (LTD)...

journal_title：Neuron

authors： Cummings JA,Mulkey RM,Nicoll RA,Malenka RC

更新日期：1996-04-01 00:00:00

abstract：:Elevation of cerebral Mg2+ with a novel orally delivered ionophore, magnesium threonate, enhances cognition in young and old rats over a 12-24 day treatment interval, as outlined in a paper by Slutsky et al. in this issue of Neuron. Despite both Mg2+ and Zn2+ blocking the NMDA receptor channel, sustained extracellular...

journal_title：Neuron

authors： Bush AI

更新日期：2010-01-28 00:00:00

abstract：:von Recklinghausen's neurofibromatosis (NF1) is a common inherited human disease. The events leading to patient symptoms from inheritance of a defective NF1 gene are unknown. Since knowledge of the distribution of the normal NF1 gene product should improve understanding of the pathogenesis of the disease, we raised an...

journal_title：Neuron

authors： Daston MM,Scrable H,Nordlund M,Sturbaum AK,Nissen LM,Ratner N

更新日期：1992-03-01 00:00:00

abstract：:Despite tremendous progress in the study of voltage-gated channels, the molecular mechanism underlying voltage sensing has remained a matter of debate. We review five new studies that make major progress in the field. The studies employ a battery of distinct approaches that have the common aim of measuring the motion ...

journal_title：Neuron

authors： Tombola F,Pathak MM,Isacoff EY

更新日期：2005-12-08 00:00:00

abstract：:Long-term memory and synaptic plasticity are thought to require the synthesis of new proteins at activated synapses. The CPEB family of RNA binding proteins, including Drosophila Orb2, has been implicated in this process. The precise mechanism by which these molecules regulate memory formation is however poorly unders...

journal_title：Neuron

authors： Krüttner S,Stepien B,Noordermeer JN,Mommaas MA,Mechtler K,Dickson BJ,Keleman K

更新日期：2012-10-18 00:00:00

abstract：:Social environment modulates learning through unknown mechanisms. Here, we report that a pheromone mixture that signals overcrowding inhibits C. elegans from learning to avoid pathogenic bacteria. We find that learning depends on the balanced signaling of two insulin-like peptides (ILPs), INS-16 and INS-4, which act r...

journal_title：Neuron

authors： Wu T,Duan F,Yang W,Liu H,Caballero A,Fernandes de Abreu DA,Dar AR,Alcedo J,Ch'ng Q,Butcher RA,Zhang Y

更新日期：2019-12-18 00:00:00

abstract：:Two rabbit polyclonal antibodies generated against different portions of the amyloid precursor protein were used to localize this protein in normal rat brain. Light and electron microscopic immunohistochemical localizations demonstrate that the protein is widely distributed throughout the neuraxis, with the highest co...

journal_title：Neuron

authors： Card JP,Meade RP,Davis LG

更新日期：1988-11-01 00:00:00

abstract：:Ultra-slow, ∼0.1-Hz variations in the oxygenation level of brain blood are widely used as an fMRI-based surrogate of "resting-state" neuronal activity. The temporal correlations among these fluctuations across the brain are interpreted as "functional connections" for maps and neurological diagnostics. Ultra-slow varia...

journal_title：Neuron

authors： Drew PJ,Mateo C,Turner KL,Yu X,Kleinfeld D

更新日期：2020-09-09 00:00:00

abstract：:We have investigated the cell cycle-related mechanisms that lead to the emergence of primate areas 17 and 18. These areas are characterized by striking differences in cytoarchitectonics and neuron number. We show in vivo that (1) area 17 precursors of supragranular neurons exhibit a shorter cell cycle duration, a redu...

journal_title：Neuron

authors： Lukaszewicz A,Savatier P,Cortay V,Giroud P,Huissoud C,Berland M,Kennedy H,Dehay C

更新日期：2005-08-04 00:00:00

abstract：:Recent reports have overturned a series of dogmas that have been well entrenched in the neuroscience literature concerning NMDA-type glutamate receptors (NMDARs). The new data show that NMDARs exist on the myelin sheath formed by oligodendrocytes, that an uncompetitive NMDAR antagonist has successfully passed human cl...

journal_title：Neuron

authors： Lipton SA

更新日期：2006-04-06 00:00:00

abstract：:Using primary cultures and immortalized multipotential stem cell lines derived from wild-type and Mash1 mutant neural crest cells, we have analyzed the cellular function of MASH1 in autonomic neurogenesis. We present evidence for the existence of a precursor expressing MASH1 and neuronal markers such as neurofilament,...

journal_title：Neuron

authors： Sommer L,Shah N,Rao M,Anderson DJ

更新日期：1995-12-01 00:00:00

abstract：:The nanoscale topographical arrangement of voltage-gated calcium channels (VGCC) and synaptic vesicles (SVs) determines synaptic strength and plasticity, but whether distinct spatial distributions underpin diversity of synaptic function is unknown. We performed single bouton Ca2+ imaging, Ca2+ chelator competition, im...

journal_title：Neuron

authors： Rebola N,Reva M,Kirizs T,Szoboszlay M,Lőrincz A,Moneron G,Nusser Z,DiGregorio DA

更新日期：2019-11-20 00:00:00

abstract：:Our tactile perception of external objects depends on skin-object interactions. The mechanics of contact dictates the existence of fundamental spatiotemporal input features-contact initiation and cessation, slip, and rolling contact-that originate from the fact that solid objects do not interpenetrate. However, it is ...

journal_title：Neuron

authors： Jörntell H,Bengtsson F,Geborek P,Spanne A,Terekhov AV,Hayward V

更新日期：2014-09-17 00:00:00

abstract：:The development of GABAergic inhibitory circuits is shaped by neural activity, but the underlying mechanisms are unclear. Here, we demonstrate a novel function of GABA in regulating GABAergic innervation in the adolescent brain, when GABA is mainly known as an inhibitory transmitter. Conditional knockdown of the rate-...

journal_title：Neuron

authors： Chattopadhyaya B,Di Cristo G,Wu CZ,Knott G,Kuhlman S,Fu Y,Palmiter RD,Huang ZJ

更新日期：2007-06-21 00:00:00

abstract：:To investigate the role of the entorhinal cortex in memory at a molecular level, we developed transgenic mice in which transgene expression was inducible and limited to the superficial layers of the medial entorhinal cortex, pre- and parasubiculum. We found that expression of a constitutively active mutant form of CaM...

journal_title：Neuron

authors： Yasuda M,Mayford MR

更新日期：2006-04-20 00:00:00

abstract：:Using high resolution capacitance measurements, we have characterized an ultrafast component of transmitter release in ribbon-type synaptic terminals of retinal bipolar neurons. During depolarization, capacitance increases to a plateau of approximately 30 fF with a time constant of approximately 1.5 ms. When not limit...

journal_title：Neuron

authors： Mennerick S,Matthews G

更新日期：1996-12-01 00:00:00

abstract：:The brain basis of language, music, and emotion can be studied from the perspective of the psychological and cognitive sciences. Does this approach link to concerns of the humanities meaningfully? We outline prospects of developing a genuine neurohumanities research program. ...

journal_title：Neuron

authors： Hartley CA,Poeppel D

更新日期：2020-11-25 00:00:00

abstract：:Neuronal population responses can vary across trials as a result of differences in the relative timing of internal brain processes. In this issue of Neuron, Williams et al. (2020) present an algorithm for inferring and inverting such trial-to-trial differences, thereby revealing an a priori hidden, precise temporal st...

journal_title：Neuron

authors： Okun M

更新日期：2020-01-22 00:00:00

abstract：:Precise apposition of presynaptic and postsynaptic domains is a fundamental property of all neuronal circuits. Experiments in vitro suggest that Neuroligins and Neurexins function as key regulatory proteins in this process. In a genetic screen, we recovered several mutant alleles of Drosophila neuroligin 1 (dnlg1) tha...

journal_title：Neuron

authors： Banovic D,Khorramshahi O,Owald D,Wichmann C,Riedt T,Fouquet W,Tian R,Sigrist SJ,Aberle H

更新日期：2010-06-10 00:00:00

abstract：:EPAC proteins are the guanine nucleotide exchange factors that act as the intracellular receptors for cyclic AMP. Two variants of EPAC genes including EPAC1 and EPAC2 are cloned and are widely expressed throughout the brain. But, their functions in the brain remain unknown. Here, we genetically delete EPAC1 (EPAC1(-/-...

journal_title：Neuron

authors： Yang Y,Shu X,Liu D,Shang Y,Wu Y,Pei L,Xu X,Tian Q,Zhang J,Qian K,Wang YX,Petralia RS,Tu W,Zhu LQ,Wang JZ,Lu Y

更新日期：2012-02-23 00:00:00

abstract：:Non-human primate neuroimaging is a rapidly growing area of research that promises to transform and scale translational and cross-species comparative neuroscience. Unfortunately, the technological and methodological advances of the past two decades have outpaced the accrual of data, which is particularly challenging g...

journal_title：Neuron

authors： Milham MP,Ai L,Koo B,Xu T,Amiez C,Balezeau F,Baxter MG,Blezer ELA,Brochier T,Chen A,Croxson PL,Damatac CG,Dehaene S,Everling S,Fair DA,Fleysher L,Freiwald W,Froudist-Walsh S,Griffiths TD,Guedj C,Hadj-Bouziane F,

更新日期：2018-10-10 00:00:00

abstract：:Here we describe the properties of a synapse in the Drosophila antennal lobe and show how they can explain certain sensory computations in this brain region. The synapse between olfactory receptor neurons (ORNs) and projection neurons (PNs) is very strong, reflecting a large number of release sites and high release pr...

journal_title：Neuron

authors： Kazama H,Wilson RI

更新日期：2008-05-08 00:00:00

abstract：:Adjustments in neural activity can drive cortical plasticity, but the underlying circuit components remain unclear. In this issue of Neuron, Barnes et al. (2015) show that visual deprivation-induced homeostatic plasticity invokes specific changes among select categories of V1 neurons. ...

journal_title：Neuron

authors： Seabrook TA,Huberman AD

更新日期：2015-06-03 00:00:00

abstract：:A critical feature of neural networks is that they balance excitation and inhibition to prevent pathological dysfunction. How this is achieved is largely unknown, although deficits in the balance contribute to many neurological disorders. We show here that a microRNA (miR-101) is a key orchestrator of this essential f...

journal_title：Neuron

authors： Lippi G,Fernandes CC,Ewell LA,John D,Romoli B,Curia G,Taylor SR,Frady EP,Jensen AB,Liu JC,Chaabane MM,Belal C,Nathanson JL,Zoli M,Leutgeb JK,Biagini G,Yeo GW,Berg DK

更新日期：2016-12-21 00:00:00