Abstract：
:The state of the brain and body constantly varies on rapid and slow timescales. These variations contribute to the apparent noisiness of sensory responses at both the neural and the behavioral level. Recent investigations of rapid state changes in awake, behaving animals have provided insight into the mechanisms by which optimal sensory encoding and behavioral performance are achieved. Fluctuations in state, as indexed by pupillometry, impact both the "signal" (sensory evoked response) and the "noise" (spontaneous activity) of cortical responses. By taking these fluctuations into account, neural response (co)variability is significantly reduced, revealing the brain to be more reliable and predictable than previously thought.
journal_name
Neuronjournal_title
Neuronauthors
McGinley MJ,Vinck M,Reimer J,Batista-Brito R,Zagha E,Cadwell CR,Tolias AS,Cardin JA,McCormick DAdoi
10.1016/j.neuron.2015.09.012subject
Has Abstractpub_date
2015-09-23 00:00:00pages
1143-1161issue
6eissn
0896-6273issn
1097-4199pii
S0896-6273(15)00769-2journal_volume
87pub_type
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