Retrograde axonal transport of LIF is increased by peripheral nerve injury: correlation with increased LIF expression in distal nerve.

abstract：:Improvement in motor skill performance is known to continue for at least 24 hr following training, yet the relative contributions of time spent awake and asleep are unknown. Here we provide evidence that a night of sleep results in a 20% increase in motor speed without loss of accuracy, while an equivalent period of t...

journal_title：Neuron

authors： Walker MP,Brakefield T,Morgan A,Hobson JA,Stickgold R

更新日期：2002-07-03 00:00:00

abstract：:The panoply of cognitive, affective, motivational, and social functions that underpin everyday human experience requires precisely choreographed patterns of interaction between networked brain regions. Perhaps not surprisingly, diverse forms of psychopathology are characterized by breakdowns in these interregional rel...

journal_title：Neuron

authors： Buckholtz JW,Meyer-Lindenberg A

更新日期：2012-06-21 00:00:00

abstract：:Experience-dependent plasticity in somatosensory (S1) and visual (V1) cortex involves rapid depression of responses to a deprived sensory input (a closed eye or a trimmed whisker). Such depression occurs first in layer II/III and may reflect plasticity at vertical inputs from layer IV to layer II/III pyramids. Here, I...

journal_title：Neuron

authors： Feldman DE

更新日期：2000-07-01 00:00:00

abstract：:Inflammatory mediators act on peripheral sensory neurons to produce pain and hypersensitivity after tissue injury. In this issue of Neuron, Dina et al. report that inflammatory mediators, such as epinephrine and prostaglandins, appear to couple to specific G protein-coupled receptor signaling pathways through plastic ...

journal_title：Neuron

authors： Bhave G,Gereau RW 4th

更新日期：2003-08-14 00:00:00

abstract：:Sexually dimorphic behaviors are likely to involve neural pathways that express the androgen receptor (AR). We have genetically modified the AR locus to visualize dimorphisms in neuronal populations that express AR. Analysis of AR-positive neurons reveals both known dimorphisms in the preoptic area of the hypothalamus...

journal_title：Neuron

authors： Shah NM,Pisapia DJ,Maniatis S,Mendelsohn MM,Nemes A,Axel R

更新日期：2004-08-05 00:00:00

abstract：:Fragile X syndrome is a leading heritable cause of mental retardation that results from the loss of FMR1 gene function. A Drosophila model for Fragile X syndrome, based on the loss of dfmr1 activity, exhibits phenotypes that bear similarity to Fragile X-related symptoms. Herein, we demonstrate that treatment with meta...

journal_title：Neuron

authors： McBride SM,Choi CH,Wang Y,Liebelt D,Braunstein E,Ferreiro D,Sehgal A,Siwicki KK,Dockendorff TC,Nguyen HT,McDonald TV,Jongens TA

更新日期：2005-03-03 00:00:00

abstract：:The sympathetic innervation of rat sweat glands undergoes a target-induced switch from a noradrenergic to a cholinergic and peptidergic phenotype during development. Treatment of cultured sympathetic neurons with sweat gland extracts mimics many of the changes seen in vivo. Extracts induce choline acetyltransferase ac...

journal_title：Neuron

authors： Rao MS,Landis SC

更新日期：1990-12-01 00:00:00

abstract：:Seizure causes a rapid and protracted increase in transcription factor AP-1 levels in the brain. The composition of AP-1 nucleoprotein complexes changes with time after seizure as a result of the sequential appearance and disappearance of Fos and several Fos-related proteins. Although these changes occur over an 8 hr ...

journal_title：Neuron

authors： Sonnenberg JL,Macgregor-Leon PF,Curran T,Morgan JI

更新日期：1989-09-01 00:00:00

abstract：:The Fragile X mental retardation protein (FMRP) regulates neuronal RNA metabolism, and its absence or mutations leads to the Fragile X syndrome (FXS). The β-amyloid precursor protein (APP) is involved in Alzheimer's disease, plays a role in synapse formation, and is upregulated in intellectual disabilities. Here, we s...

journal_title：Neuron

authors： Pasciuto E,Ahmed T,Wahle T,Gardoni F,D'Andrea L,Pacini L,Jacquemont S,Tassone F,Balschun D,Dotti CG,Callaerts-Vegh Z,D'Hooge R,Müller UC,Di Luca M,De Strooper B,Bagni C

更新日期：2015-07-15 00:00:00

abstract：:Two mutations in the sodium channel alpha subunit that have been implicated as the cause of periodic paralysis were studied by functional expression in a mammalian cell line. Both mutations disrupted inactivation without affecting the time course of the onset of the sodium current or the single-channel conductance. Th...

journal_title：Neuron

authors： Cannon SC,Strittmatter SM

更新日期：1993-02-01 00:00:00

abstract：:Brain-derived neurotrophic factor (BDNF) is expressed at high levels in hippocampal neurons, and its expression is modulated by neural activity. Knockout mice can be used to study the roles of molecules like BDNF in synaptic plasticity with more molecular specificity than is possible using pharmacological approaches. ...

journal_title：Neuron

authors： Patterson SL,Abel T,Deuel TA,Martin KC,Rose JC,Kandel ER

更新日期：1996-06-01 00:00:00

abstract：:Microglia are the immune cells of the brain. Here we show a massive infiltration of highly ramified and elongated microglia within the core of amyloid plaques in transgenic mouse models of Alzheimer's disease (AD). Many of these cells originate from the bone marrow, and the beta-amyloid-40 and -42 isoforms are able to...

journal_title：Neuron

authors： Simard AR,Soulet D,Gowing G,Julien JP,Rivest S

更新日期：2006-02-16 00:00:00

abstract：:The differentiation of neuronal cell progenitors depends on complex interactions between intrinsic cellular programs and environmental cues. Such interactions have recently been explored using an immortalized sympathoadrenal progenitor cell line, MAH. These studies have revealed that depolarizing conditions, in combin...

journal_title：Neuron

authors： Ip NY,Boulton TG,Li Y,Verdi JM,Birren SJ,Anderson DJ,Yancopoulos GD

更新日期：1994-08-01 00:00:00

abstract：:Recent progress in neurophysiological recording has developed in two directions. One relies on multimicroelectrodes to study correlations in neuron firing. The other relies on sophisticated tasks to distinguish successive stages of neuronal processing. In this issue of Neuron, Shichinohe et al. take this second approa...

journal_title：Neuron

authors： Schlag JD,Schlag-Rey M

更新日期：2009-06-11 00:00:00

abstract：:The relative timing of presynaptic and postsynaptic spikes plays a critical role in activity-induced synaptic modification. Here we examined whether plasticity of orientation selectivity in the visual cortex depends on stimulus timing. Repetitive pairing of visual stimuli at two orientations induced a shift in orienta...

journal_title：Neuron

authors： Yao H,Dan Y

更新日期：2001-10-25 00:00:00

abstract：:The molecular mechanisms involved in glial/neuronal fate decisions during embryonic development are largely unknown. Here we show that the segment-polarity gene engrailed, which encodes a homeodomain protein, controls these decisions within an insect CNS lineage. The grasshopper median neuroblast (MNB) generates both ...

journal_title：Neuron

authors： Condron BG,Patel NH,Zinn K

更新日期：1994-09-01 00:00:00

abstract：:Two articles in this issue of Neuron (Eichner et al. and Clark et al.) attack the problem of explaining how neuronal hardware in Drosophila implements the Reichardt motion detector, one of the most famous computational models in neuroscience, which has proven intractable up to now. ...

journal_title：Neuron

authors： Gabbiani F,Jones PW

更新日期：2011-06-23 00:00:00

abstract：:There has been a surge of interest in how inhibitory neurons influence the output of local circuits in the brain. In this issue of Neuron, Scholl et al. (2015) provide a compelling argument for what one class of inhibitory neurons actually does. ...

journal_title：Neuron

authors： Trachtenberg JT

更新日期：2015-07-15 00:00:00

abstract：:Little is known about the molecular mechanisms underlying differences in the ligand binding properties of AMPA, kainate, and NMDA subtype glutamate receptors. Crystal structures of the GluR5 and GluR6 kainate receptor ligand binding cores in complexes with glutamate, 2S,4R-4-methylglutamate, kainate, and quisqualate h...

journal_title：Neuron

authors： Mayer ML

更新日期：2005-02-17 00:00:00

abstract：:We have analyzed alternatively spliced beta amyloid protein precursor (beta APP) mRNAs by using the polymerase chain reaction to amplify beta APP cDNAs produced by reverse transcription. With this approach the three previously characterized beta APP mRNAs (beta APP695, beta APP751, and beta APP770) are readily detecte...

journal_title：Neuron

authors： Golde TE,Estus S,Usiak M,Younkin LH,Younkin SG

更新日期：1990-02-01 00:00:00

abstract：:Sensory systems change their sensitivity based on recent stimuli to adjust their response range to the range of inputs and to predict future sensory input. Here, we report the presence of retinal ganglion cells that have antagonistic plasticity, showing central adaptation and peripheral sensitization. Ganglion cell re...

journal_title：Neuron

authors： Kastner DB,Baccus SA

更新日期：2013-08-07 00:00:00

abstract：:Changes in intracellular calcium (Ca) concentration following synaptic and suprathreshold activity are mediated by a wide range of sources and contribute to the regulation of myriad neuronal functions. The development of Ca imaging techniques has dramatically increased our understanding of the complex interactions bet...

journal_title：Neuron

authors： Higley MJ,Sabatini BL

更新日期：2008-09-25 00:00:00

abstract：:In this issue of Neuron, Stepanyants et al. embark on quantitative analyses of the axonal and dendritic arbors of cortical neurons. They test whether the paths taken by axons actually bring them closer to their true synaptic partners than they would have gotten by chance encounters based on the same axon trajectories....

journal_title：Neuron

authors： Callaway EM

更新日期：2004-07-22 00:00:00

abstract：:The retinal pigment epithelium (RPE) plays an essential role in the normal development of the underlying neural retina, but the mechanisms by which this regulation occurs are largely unknown. Ca2+ transients, induced by the neurotransmitter ATP acting on purinergic receptors, both increase proliferation and stimulate ...

journal_title：Neuron

authors： Pearson RA,Dale N,Llaudet E,Mobbs P

更新日期：2005-06-02 00:00:00

abstract：:The prefrontal cortex (PFC) plays a key role in controlling goal-directed behavior. Although a variety of task-related signals have been observed in the PFC, whether they are differentially encoded by various cell types remains unclear. Here we performed cellular-resolution microendoscopic Ca(2+) imaging from genetica...

journal_title：Neuron

authors： Pinto L,Dan Y

更新日期：2015-07-15 00:00:00

abstract：:Neuroscientific findings are rarely translated into public policies that improve the health and well-being of people experiencing serious disorders. I advocate here for investment in policymaker-scientist networks dedicated to such translation for a range of diseases. ...

journal_title：Neuron

authors： Humphreys K

更新日期：2019-09-25 00:00:00

abstract：:Although animal studies provided significant insights in understanding the neural basis of learning and adaptation, they often cannot dissociate between different learning mechanisms due to the lack of verbal communication. To overcome this limitation, we examined the mechanisms of learning and its limits in a human i...

journal_title：Neuron

authors： Sakellaridi S,Christopoulos VN,Aflalo T,Pejsa KW,Rosario ER,Ouellette D,Pouratian N,Andersen RA

更新日期：2019-05-08 00:00:00

abstract：:Synaptic remodeling has been postulated as a mechanism underlying synaptic plasticity, and cadherin adhesion molecules are thought to be a regulator of such a process. We examined the effects of cadherin blockage on synaptogenesis in cultured hippocampal neurons. This blockade resulted in alterations of dendritic spin...

journal_title：Neuron

authors： Togashi H,Abe K,Mizoguchi A,Takaoka K,Chisaka O,Takeichi M

更新日期：2002-07-03 00:00:00

abstract：:Interactions between genetic and epigenetic effects shape brain function, behavior, and the risk for mental illness. Random X inactivation and genomic imprinting are epigenetic allelic effects that are well known to influence genetic architecture and disease risk. Less is known about the nature, prevalence, and conser...

journal_title：Neuron

authors： Huang WC,Ferris E,Cheng T,Hörndli CS,Gleason K,Tamminga C,Wagner JD,Boucher KM,Christian JL,Gregg C

更新日期：2017-03-08 00:00:00

abstract：:Identifying the spatial organization of tissues at cellular resolution from single-cell gene expression profiles is essential to understanding biological systems. Using an in situ 3D multiplexed imaging method, seqFISH, we identify unique transcriptional states by quantifying and clustering up to 249 genes in 16,958 c...

journal_title：Neuron

authors： Shah S,Lubeck E,Zhou W,Cai L

更新日期：2016-10-19 00:00:00