Neuroscience of behavioral and pharmacological treatments for addictions.


:Although substantial advances have been made in behavioral and pharmacological treatments for addictions, moving treatment development to the next stage may require novel ways of approaching addictions, particularly ways based on new findings regarding the neurobiological underpinnings of addictions that also assimilate and incorporate relevant information from earlier approaches. In this review, we first briefly review theoretical and biological models of addiction and then describe existing behavioral and pharmacologic therapies for the addictions within this framework. We then propose new directions for treatment development and targets that are informed by recent evidence regarding the heterogeneity of addictions and the neurobiological contributions to these disorders.






Potenza MN,Sofuoglu M,Carroll KM,Rounsaville BJ




Has Abstract


2011-02-24 00:00:00
















  • Hierarchical Encoding of Attended Auditory Objects in Multi-talker Speech Perception.

    abstract::Humans can easily focus on one speaker in a multi-talker acoustic environment, but how different areas of the human auditory cortex (AC) represent the acoustic components of mixed speech is unknown. We obtained invasive recordings from the primary and nonprimary AC in neurosurgical patients as they listened to multi-t...


    pub_type: 杂志文章


    authors: O'Sullivan J,Herrero J,Smith E,Schevon C,McKhann GM,Sheth SA,Mehta AD,Mesgarani N

    更新日期:2019-12-18 00:00:00

  • Dopamine D3 receptor mutant mice exhibit increased behavioral sensitivity to concurrent stimulation of D1 and D2 receptors.

    abstract::The dopamine D3 receptor is expressed primarily in regions of the brain that are thought to influence motivation and motor functions. To specify in vivo D3 receptor function, we generated mutant mice lacking this receptor. Our analysis indicates that in a novel environment, D3 mutant mice are transiently more active t...


    pub_type: 杂志文章


    authors: Xu M,Koeltzow TE,Santiago GT,Moratalla R,Cooper DC,Hu XT,White NM,Graybiel AM,White FJ,Tonegawa S

    更新日期:1997-10-01 00:00:00

  • An essential role for a MEK-C/EBP pathway during growth factor-regulated cortical neurogenesis.

    abstract::Mammalian neurogenesis is determined by an interplay between intrinsic genetic mechanisms and extrinsic cues such as growth factors. Here we have defined a signaling cascade, a MEK-C/EBP pathway, that is essential for cortical progenitor cells to become postmitotic neurons. Inhibition of MEK or of the C/EBP family of ...


    pub_type: 杂志文章


    authors: Ménard C,Hein P,Paquin A,Savelson A,Yang XM,Lederfein D,Barnabé-Heider F,Mir AA,Sterneck E,Peterson AC,Johnson PF,Vinson C,Miller FD

    更新日期:2002-11-14 00:00:00

  • Making an effort to listen: mechanical amplification in the ear.

    abstract::The inner ear's performance is greatly enhanced by an active process defined by four features: amplification, frequency selectivity, compressive nonlinearity, and spontaneous otoacoustic emission. These characteristics emerge naturally if the mechanoelectrical transduction process operates near a dynamical instability...


    pub_type: 杂志文章,评审


    authors: Hudspeth AJ

    更新日期:2008-08-28 00:00:00

  • Drosophila Dscam is required for divergent segregation of sister branches and suppresses ectopic bifurcation of axons.

    abstract::Axon bifurcation results in the formation of sister branches, and divergent segregation of the sister branches is essential for efficient innervation of multiple targets. From a genetic mosaic screen, we find that a lethal mutation in the Drosophila Down syndrome cell adhesion molecule (Dscam) specifically perturbs se...


    pub_type: 杂志文章


    authors: Wang J,Zugates CT,Liang IH,Lee CH,Lee T

    更新日期:2002-02-14 00:00:00

  • Subunit composition of synaptic AMPA receptors revealed by a single-cell genetic approach.

    abstract::The precise subunit composition of synaptic ionotropic receptors in the brain is poorly understood. This information is of particular importance with regard to AMPA-type glutamate receptors, the multimeric complexes assembled from GluA1-A4 subunits, as the trafficking of these receptors into and out of synapses is pro...


    pub_type: 杂志文章


    authors: Lu W,Shi Y,Jackson AC,Bjorgan K,During MJ,Sprengel R,Seeburg PH,Nicoll RA

    更新日期:2009-04-30 00:00:00

  • Sequences of autophosphorylation sites in neuronal type II CaM kinase that control Ca2(+)-independent activity.

    abstract::After initial activation by Ca2+, the catalytic activity of type II Ca2+/calmodulin-dependent protein kinase rapidly becomes partially independent of Ca2+. The transition is caused by autophosphorylation of a few subunits in the dodecameric holoenzyme, which is composed of varying proportions of two homologous types o...


    pub_type: 杂志文章


    authors: Miller SG,Patton BL,Kennedy MB

    更新日期:1988-09-01 00:00:00

  • Innate immunity in the CNS: redefining the relationship between the CNS and Its environment.

    abstract::The concept of the CNS as an immune-privileged organ has led to a common misunderstanding that it is not an active immunological organ, guarded from its surroundings by the blood-brain barrier (BBB). Recent advances in this field clearly demonstrate that the CNS is a highly immunologically active organ, with complex i...


    pub_type: 杂志文章,评审


    authors: Lampron A,Elali A,Rivest S

    更新日期:2013-04-24 00:00:00

  • Anterior regions of monkey parietal cortex process visual 3D shape.

    abstract::The intraparietal cortex is involved in the control of visually guided actions, like reach-to-grasp movements, which require extracting the 3D shape and position of objects from 2D retinal images. Using fMRI in behaving monkeys, we investigated the role of the intraparietal cortex in processing stereoscopic informatio...


    pub_type: 杂志文章


    authors: Durand JB,Nelissen K,Joly O,Wardak C,Todd JT,Norman JF,Janssen P,Vanduffel W,Orban GA

    更新日期:2007-08-02 00:00:00

  • Recombinase-driver rat lines: tools, techniques, and optogenetic application to dopamine-mediated reinforcement.

    abstract::Currently there is no general approach for achieving specific optogenetic control of genetically defined cell types in rats, which provide a powerful experimental system for numerous established neurophysiological and behavioral paradigms. To overcome this challenge we have generated genetically restricted recombinase...


    pub_type: 杂志文章


    authors: Witten IB,Steinberg EE,Lee SY,Davidson TJ,Zalocusky KA,Brodsky M,Yizhar O,Cho SL,Gong S,Ramakrishnan C,Stuber GD,Tye KM,Janak PH,Deisseroth K

    更新日期:2011-12-08 00:00:00

  • Bayesian Computation through Cortical Latent Dynamics.

    abstract::Statistical regularities in the environment create prior beliefs that we rely on to optimize our behavior when sensory information is uncertain. Bayesian theory formalizes how prior beliefs can be leveraged and has had a major impact on models of perception, sensorimotor function, and cognition. However, it is not kno...


    pub_type: 杂志文章


    authors: Sohn H,Narain D,Meirhaeghe N,Jazayeri M

    更新日期:2019-09-04 00:00:00

  • Transient slow gamma synchrony underlies hippocampal memory replay.

    abstract::The replay of previously stored memories during hippocampal sharp wave ripples (SWRs) is thought to support both memory retrieval and consolidation in distributed hippocampal-neocortical circuits. Replay events consist of precisely timed sequences of spikes from CA3 and CA1 neurons that are coordinated both within and...


    pub_type: 杂志文章


    authors: Carr MF,Karlsson MP,Frank LM

    更新日期:2012-08-23 00:00:00

  • Identification of M-channels in outside-out patches excised from sympathetic ganglion cells.

    abstract::We have identified the species of K+ channel that underlies the neuronal M-current in rat sympathetic ganglion cells. The channels were kinetically and pharmacologically defined using outside-out and cell-attached patches. They exhibited multiple conductance levels, predominantly 3-9 pS. Their slow gating in response ...


    pub_type: 杂志文章


    authors: Stansfeld CE,Marsh SJ,Gibb AJ,Brown DA

    更新日期:1993-04-01 00:00:00

  • Blockade of ion channel expression in Xenopus oocytes with complementary DNA probes to Na+ and K+ channel mRNAs.

    abstract::Ionic currents were recorded from Xenopus oocytes injected with RNA isolated from chick or mouse brain. Three currents were studied: a rapid tetrodotoxin-sensitive Na+ current (Ina), an early outward K+ current sensitive to 4-aminopyridine (IA), and an inward current activated by the excitatory amino acid receptor ago...


    pub_type: 杂志文章


    authors: Lotan I,Volterra A,Dash P,Siegelbaum SA,Goelet P

    更新日期:1988-12-01 00:00:00

  • Conscious Processing and the Global Neuronal Workspace Hypothesis.

    abstract::We review the central tenets and neuroanatomical basis of the global neuronal workspace (GNW) hypothesis, which attempts to account for the main scientific observations regarding the elementary mechanisms of conscious processing in the human brain. The GNW hypothesis proposes that, in the conscious state, a non-linear...


    pub_type: 杂志文章,评审


    authors: Mashour GA,Roelfsema P,Changeux JP,Dehaene S

    更新日期:2020-03-04 00:00:00

  • Selective gating of glutamatergic inputs to excitatory neurons of amygdala by presynaptic GABAb receptor.

    abstract::GABAb receptor (GABAbR)-mediated suppression of glutamate release is critical for limiting glutamatergic transmission across the central nervous system (CNS). Here we show that, upon tetanic stimulation of afferents to lateral amygdala, presynaptic GABAbR-mediated inhibition only occurs in glutamatergic inputs to prin...


    pub_type: 杂志文章


    authors: Pan BX,Dong Y,Ito W,Yanagawa Y,Shigemoto R,Morozov A

    更新日期:2009-03-26 00:00:00

  • A Mirror-Symmetric Excitatory Link Coordinates Odor Maps across Olfactory Bulbs and Enables Odor Perceptual Unity.

    abstract::Sensory input reaching the brain from bilateral and offset channels is nonetheless perceived as unified. This unity could be explained by simultaneous projections to both hemispheres, or inter-hemispheric information transfer between sensory cortical maps. Odor input, however, is not topographically organized, nor doe...


    pub_type: 杂志文章


    authors: Grobman M,Dalal T,Lavian H,Shmuel R,Belelovsky K,Xu F,Korngreen A,Haddad R

    更新日期:2018-08-22 00:00:00

  • Synapses with inhibitory neurons differentiate anterior cingulate from dorsolateral prefrontal pathways associated with cognitive control.

    abstract::The primate dorsolateral prefrontal cortex (DLPFC) and anterior cingulate cortex (ACC) focus attention on relevant signals and suppress noise in cognitive tasks. However, their synaptic interactions and unique roles in cognitive control are unknown. We report that two distinct pathways to DLPFC area 9, one from the ne...


    pub_type: 杂志文章


    authors: Medalla M,Barbas H

    更新日期:2009-02-26 00:00:00

  • Reorganization of striatal inhibitory microcircuits leads to pathological synchrony in the Basal Ganglia.

    abstract::Neural synchronization plays an important role in information flow in the nervous system under healthy and pathological conditions. In this issue of Neuron, Gittis et al. show that reorganization of striatal microcircuits promotes synchronous activity and may underlie the pathological network oscillations at the root ...


    pub_type: 评论,杂志文章


    authors: Belujon P,Grace AA

    更新日期:2011-09-08 00:00:00

  • Location and Plasticity of the Sodium Spike Initiation Zone in Nociceptive Terminals In Vivo.

    abstract::Nociceptive terminals possess the elements for detecting, transmitting, and modulating noxious signals, thus being pivotal for pain sensation. Despite this, a functional description of the transduction process by the terminals, in physiological conditions, has not been fully achieved. Here, we studied how nociceptive ...


    pub_type: 杂志文章


    authors: Goldstein RH,Barkai O,Íñigo-Portugués A,Katz B,Lev S,Binshtok AM

    更新日期:2019-05-22 00:00:00

  • Initiation of rhombomeric Hoxb4 expression requires induction by somites and a retinoid pathway.

    abstract::Anteroposterior (AP) patterning in the vertebrate hindbrain is dependent upon the establishment of segmental domains of Hox expression. We investigated the mechanism that governs the early expression of Hoxb4 and found that transient signaling from the paraxial mesoderm induces expression in the hindbrain. Induction i...


    pub_type: 杂志文章


    authors: Gould A,Itasaki N,Krumlauf R

    更新日期:1998-07-01 00:00:00

  • Independent binocular rivalry processes for motion and form.

    abstract::During binocular rivalry, conflicting monocular images undergo alternating suppression. This study explores rivalry suppression by probing visual sensitivity during rivalry with various probe stimuli. When two faces engage in rivalry, sensitivity to face probes is reduced 4-fold during suppression. Rivaling global mot...


    pub_type: 杂志文章


    authors: Alais D,Parker A

    更新日期:2006-12-07 00:00:00

  • Semantic memory and the human hippocampus.

    abstract::It has been unclear whether the hippocampus is uniquely important for episodic memory (memory for events that are specific to time and place) or whether the hippocampus is also important for learning and remembering facts (semantic memory). In two studies, we assessed the capacity for semantic memory in patients with ...


    pub_type: 杂志文章


    authors: Manns JR,Hopkins RO,Squire LR

    更新日期:2003-04-10 00:00:00

  • Selective reduction of one mode of M-channel gating by muscarine in sympathetic neurons.

    abstract::M-current is widespread in the nervous system. It stabilizes cell excitability, and its suppression by muscarinic receptor activation underlies slow synaptic transmission in sympathetic neurons. Suppression of M-current was one of the first examples of neuromodulation of a potassium current, but the mechanism is not u...


    pub_type: 杂志文章


    authors: Marrion NV

    更新日期:1993-07-01 00:00:00

  • A Central Move for CB2 Receptors.

    abstract::The function of the CB2 cannabinoid receptor in the brain has long been a matter of debate. In this issue of Neuron, Stempel et al. (2016) describe a mechanism whereby endocannabinoid production leads to a cell-intrinsic hyperpolarization that controls self activity. ...


    pub_type: 评论,杂志文章,评审


    authors: Quraishi SA,Paladini CA

    更新日期:2016-05-18 00:00:00

  • Resolving Memory Circuits with Layer-Dependent fMRI.

    abstract::Memory encoding and retrieval require directional exchange of information between different areas in the medial temporal lobe. In this issue of Neuron, Koster et al. (2018) use high-resolution fMRI combined with state-of-the-art data analysis methods to trace the information flow in memory circuits in hippocampus and ...


    pub_type: 评论,杂志文章


    authors: Goense J

    更新日期:2018-09-19 00:00:00

  • Ultrafast exocytosis elicited by calcium current in synaptic terminals of retinal bipolar neurons.

    abstract::Using high resolution capacitance measurements, we have characterized an ultrafast component of transmitter release in ribbon-type synaptic terminals of retinal bipolar neurons. During depolarization, capacitance increases to a plateau of approximately 30 fF with a time constant of approximately 1.5 ms. When not limit...


    pub_type: 杂志文章


    authors: Mennerick S,Matthews G

    更新日期:1996-12-01 00:00:00

  • Differential Coding of Itch and Pain by a Subpopulation of Primary Afferent Neurons.

    abstract::Itch and pain are distinct unpleasant sensations that can be triggered from the same receptive fields in the skin, raising the question of how pruriception and nociception are coded and discriminated. Here, we tested the multimodal capacity of peripheral first-order neurons, focusing on the genetically defined subpopu...


    pub_type: 杂志文章


    authors: Sharif B,Ase AR,Ribeiro-da-Silva A,Séguéla P

    更新日期:2020-06-17 00:00:00

  • Localization of the alpha 1 and alpha 2 subunits of the dihydropyridine receptor and ankyrin in skeletal muscle triads.

    abstract::We have studied the subcellular distribution of the alpha 1 and alpha 2 subunits of the dihydropyridine (DHP) receptor and ankyrin in rat skeletal muscle with immunofluorescence and immunogold labeling techniques. All three proteins were concentrated in the triad junction formed between the T-tubules and sarcoplasmic ...


    pub_type: 杂志文章


    authors: Flucher BE,Morton ME,Froehner SC,Daniels MP

    更新日期:1990-09-01 00:00:00

  • Unusual topography of bovine rhodopsin promoter-lacZ fusion gene expression in transgenic mouse retinas.

    abstract::To define the cis-acting DNA elements required for rhodopsin expression, we generated lines of transgenic mice carrying sequences upstream of the bovine rhodopsin gene fused to the E. coli beta-galactosidase gene (lacZ). Upstream sequences extending from -2174 to +70 bp, from -734 to +70 bp, and from -222 to +70 bp di...


    pub_type: 杂志文章


    authors: Zack DJ,Bennett J,Wang Y,Davenport C,Klaunberg B,Gearhart J,Nathans J

    更新日期:1991-02-01 00:00:00