Neuroscience of behavioral and pharmacological treatments for addictions.


:Although substantial advances have been made in behavioral and pharmacological treatments for addictions, moving treatment development to the next stage may require novel ways of approaching addictions, particularly ways based on new findings regarding the neurobiological underpinnings of addictions that also assimilate and incorporate relevant information from earlier approaches. In this review, we first briefly review theoretical and biological models of addiction and then describe existing behavioral and pharmacologic therapies for the addictions within this framework. We then propose new directions for treatment development and targets that are informed by recent evidence regarding the heterogeneity of addictions and the neurobiological contributions to these disorders.






Potenza MN,Sofuoglu M,Carroll KM,Rounsaville BJ




Has Abstract


2011-02-24 00:00:00
















  • More Than the Sum of Its Parts: A Role for the Hippocampus in Configural Reinforcement Learning.

    abstract::People often perceive configurations rather than the elements they comprise, a bias that may emerge because configurations often predict outcomes. But how does the brain learn to associate configurations with outcomes and how does this learning differ from learning about individual elements? We combined behavior, rein...


    pub_type: 杂志文章


    authors: Duncan K,Doll BB,Daw ND,Shohamy D

    更新日期:2018-05-02 00:00:00

  • Initiation of rhombomeric Hoxb4 expression requires induction by somites and a retinoid pathway.

    abstract::Anteroposterior (AP) patterning in the vertebrate hindbrain is dependent upon the establishment of segmental domains of Hox expression. We investigated the mechanism that governs the early expression of Hoxb4 and found that transient signaling from the paraxial mesoderm induces expression in the hindbrain. Induction i...


    pub_type: 杂志文章


    authors: Gould A,Itasaki N,Krumlauf R

    更新日期:1998-07-01 00:00:00

  • Facilitation of NMDAR-independent LTP and spatial learning in mutant mice lacking ryanodine receptor type 3.

    abstract::To evaluate the role in synaptic plasticity of ryanodine receptor type 3 (RyR3), which is normally enriched in hippocampal area CA1, we generated RyR3-deficient mice. Mutant mice exhibited facilitated CA1 long-term potentiation (LTP) induced by short tetanus (100 Hz, 100 ms) stimulation. Unlike LTP in wild-type mice, ...


    pub_type: 杂志文章


    authors: Futatsugi A,Kato K,Ogura H,Li ST,Nagata E,Kuwajima G,Tanaka K,Itohara S,Mikoshiba K

    更新日期:1999-11-01 00:00:00

  • Figuring space by time.

    abstract::Sensory information is encoded both in space and in time. Spatial encoding is based on the identity of activated receptors, while temporal encoding is based on the timing of activation. In order to generate accurate internal representations of the external world, the brain must decode both types of encoded information...


    pub_type: 杂志文章,评审


    authors: Ahissar E,Arieli A

    更新日期:2001-10-25 00:00:00

  • Detection of brain-derived neurotrophic factor-like activity in fibroblasts and Schwann cells: inhibition by antibodies to NGF.

    abstract::mRNA coding for brain-derived neurotrophic factor (BDNF) has been detected in cultured L929 fibroblasts, rat dermal fibroblasts, and sciatic nerve Schwann cells, as well as in rat skin. Medium conditioned by cultured fibroblasts and Schwann cells also stimulates neurite growth from retinal explants and promotes the su...


    pub_type: 杂志文章


    authors: Acheson A,Barker PA,Alderson RF,Miller FD,Murphy RA

    更新日期:1991-08-01 00:00:00

  • Adrenergic Gate Release for Spike Timing-Dependent Synaptic Potentiation.

    abstract::Spike timing-dependent synaptic plasticity (STDP) serves as a key cellular correlate of associative learning, which is facilitated by elevated attentional and emotional states involving activation of adrenergic signaling. At cellular levels, adrenergic signaling increases dendrite excitability, but the underlying mech...


    pub_type: 杂志文章


    authors: Liu Y,Cui L,Schwarz MK,Dong Y,Schlüter OM

    更新日期:2017-01-18 00:00:00

  • Multiple Running Speed Signals in Medial Entorhinal Cortex.

    abstract::Grid cells in medial entorhinal cortex (MEC) can be modeled using oscillatory interference or attractor dynamic mechanisms that perform path integration, a computation requiring information about running direction and speed. The two classes of computational models often use either an oscillatory frequency or a firing ...


    pub_type: 杂志文章


    authors: Hinman JR,Brandon MP,Climer JR,Chapman GW,Hasselmo ME

    更新日期:2016-08-03 00:00:00

  • Reactive astrocytes are substrates for the growth of adult CNS axons in the presence of elevated levels of nerve growth factor.

    abstract::To assess the necessary parameters for the growth of axons within the adult rat CNS, we have used intracerebral grafts of primary fibroblasts genetically engineered to express nerve growth factor (NGF). Following the implantation of NGF-producing primary fibroblasts within the striatum, cholinergic axons arising from ...


    pub_type: 杂志文章


    authors: Kawaja MD,Gage FH

    更新日期:1991-12-01 00:00:00

  • The protein product of the neurofibromatosis type 1 gene is expressed at highest abundance in neurons, Schwann cells, and oligodendrocytes.

    abstract::von Recklinghausen's neurofibromatosis (NF1) is a common inherited human disease. The events leading to patient symptoms from inheritance of a defective NF1 gene are unknown. Since knowledge of the distribution of the normal NF1 gene product should improve understanding of the pathogenesis of the disease, we raised an...


    pub_type: 杂志文章


    authors: Daston MM,Scrable H,Nordlund M,Sturbaum AK,Nissen LM,Ratner N

    更新日期:1992-03-01 00:00:00

  • Disruption of RNA Metabolism in Neurological Diseases and Emerging Therapeutic Interventions.

    abstract::RNA binding proteins are critical to the maintenance of the transcriptome via controlled regulation of RNA processing and transport. Alterations of these proteins impact multiple steps of the RNA life cycle resulting in various molecular phenotypes such as aberrant RNA splicing, transport, and stability. Disruption of...


    pub_type: 杂志文章,评审


    authors: Nussbacher JK,Tabet R,Yeo GW,Lagier-Tourenne C

    更新日期:2019-04-17 00:00:00

  • cGMP-mediated facilitation in nerve terminals by enhancement of the spike afterhyperpolarization.

    abstract::cGMP has long been suspected to play a role in synaptic plasticity, but the inaccessibility of nerve terminals to electrical recording has impeded tests of this hypothesis. In posterior pituitary nerve terminals, nitric oxide enhanced Ca(2+)-activated K+ channel activity by activating guanylate cyclase and PKG. This e...


    pub_type: 杂志文章


    authors: Klyachko VA,Ahern GP,Jackson MB

    更新日期:2001-09-27 00:00:00

  • LTP Induction Boosts Glutamate Spillover by Driving Withdrawal of Perisynaptic Astroglia.

    abstract::Extrasynaptic actions of glutamate are limited by high-affinity transporters expressed by perisynaptic astroglial processes (PAPs): this helps maintain point-to-point transmission in excitatory circuits. Memory formation in the brain is associated with synaptic remodeling, but how this affects PAPs and therefore extra...


    pub_type: 杂志文章


    authors: Henneberger C,Bard L,Panatier A,Reynolds JP,Kopach O,Medvedev NI,Minge D,Herde MK,Anders S,Kraev I,Heller JP,Rama S,Zheng K,Jensen TP,Sanchez-Romero I,Jackson CJ,Janovjak H,Ottersen OP,Nagelhus EA,Oliet SHR,Stewar

    更新日期:2020-12-09 00:00:00

  • Context-dependent encoding in the human auditory brainstem relates to hearing speech in noise: implications for developmental dyslexia.

    abstract::We examined context-dependent encoding of speech in children with and without developmental dyslexia by measuring auditory brainstem responses to a speech syllable presented in a repetitive or variable context. Typically developing children showed enhanced brainstem representation of features related to voice pitch in...


    pub_type: 杂志文章


    authors: Chandrasekaran B,Hornickel J,Skoe E,Nicol T,Kraus N

    更新日期:2009-11-12 00:00:00

  • Single-trial neural correlates of arm movement preparation.

    abstract::The process by which neural circuitry in the brain plans and executes movements is not well understood. Until recently, most available data were limited either to single-neuron electrophysiological recordings or to measures of aggregate field or metabolism. Neither approach reveals how individual neurons' activities a...


    pub_type: 杂志文章


    authors: Afshar A,Santhanam G,Yu BM,Ryu SI,Sahani M,Shenoy KV

    更新日期:2011-08-11 00:00:00

  • Spontaneous Synaptic Activation of Muscarinic Receptors by Striatal Cholinergic Neuron Firing.

    abstract::Cholinergic interneurons (CHIs) play a major role in motor and learning functions of the striatum. As acetylcholine does not directly evoke postsynaptic events at most striatal synapses, it remains unclear how postsynaptic cholinergic receptors encode the firing patterns of CHIs in the striatum. To examine the dynamic...


    pub_type: 杂志文章


    authors: Mamaligas AA,Ford CP

    更新日期:2016-08-03 00:00:00

  • Presynaptic partners of dorsal raphe serotonergic and GABAergic neurons.

    abstract::The serotonin system powerfully modulates physiology and behavior in health and disease, yet the circuit mechanisms underlying serotonin neuron activity are poorly understood. The major source of forebrain serotonergic innervation is from the dorsal raphe nucleus (DR), which contains both serotonin and GABA neurons. U...


    pub_type: 杂志文章


    authors: Weissbourd B,Ren J,DeLoach KE,Guenthner CJ,Miyamichi K,Luo L

    更新日期:2014-08-06 00:00:00

  • Nucleus Accumbens Subnuclei Regulate Motivated Behavior via Direct Inhibition and Disinhibition of VTA Dopamine Subpopulations.

    abstract::Mesolimbic dopamine (DA) neurons play a central role in motivation and reward processing. Although the activity of these mesolimbic DA neurons is controlled by afferent inputs, little is known about the circuits in which they are embedded. Using retrograde tracing, electrophysiology, optogenetics, and behavioral assay...


    pub_type: 杂志文章


    authors: Yang H,de Jong JW,Tak Y,Peck J,Bateup HS,Lammel S

    更新日期:2018-01-17 00:00:00

  • Axo-axonal coupling. a novel mechanism for ultrafast neuronal communication.

    abstract::We provide physiological, pharmacological, and structural evidence that axons of hippocampal principal cells are electrically coupled, with prepotentials or spikelets forming the physiological substrate of electrical coupling as observed in cell somata. Antidromic activation of neighboring axons induced somatic spikel...


    pub_type: 杂志文章


    authors: Schmitz D,Schuchmann S,Fisahn A,Draguhn A,Buhl EH,Petrasch-Parwez E,Dermietzel R,Heinemann U,Traub RD

    更新日期:2001-09-13 00:00:00

  • Signatures of a Statistical Computation in the Human Sense of Confidence.

    abstract::Human confidence judgments are thought to originate from metacognitive processes that provide a subjective assessment about one's beliefs. Alternatively, confidence is framed in mathematics as an objective statistical quantity: the probability that a chosen hypothesis is correct. Despite similar terminology, it remain...


    pub_type: 杂志文章


    authors: Sanders JI,Hangya B,Kepecs A

    更新日期:2016-05-04 00:00:00

  • Disruption of ClC-3, a chloride channel expressed on synaptic vesicles, leads to a loss of the hippocampus.

    abstract::Several plasma membrane chloride channels are well characterized, but much less is known about the molecular identity and function of intracellular Cl- channels. ClC-3 is thought to mediate swelling-activated plasma membrane currents, but we now show that this broadly expressed chloride channel is present in endosomal...


    pub_type: 杂志文章


    authors: Stobrawa SM,Breiderhoff T,Takamori S,Engel D,Schweizer M,Zdebik AA,Bösl MR,Ruether K,Jahn H,Draguhn A,Jahn R,Jentsch TJ

    更新日期:2001-01-01 00:00:00

  • Peripheral demyelination and neuropathic pain behavior in periaxin-deficient mice.

    abstract::The Prx gene in Schwann cells encodes L- and S-periaxin, two abundant PDZ domain proteins thought to have a role in the stabilization of myelin in the peripheral nervous system (PNS). Mice lacking a functional Prx gene assemble compact PNS myelin. However, the sheath is unstable, leading to demyelination and reflex be...


    pub_type: 杂志文章


    authors: Gillespie CS,Sherman DL,Fleetwood-Walker SM,Cottrell DF,Tait S,Garry EM,Wallace VC,Ure J,Griffiths IR,Smith A,Brophy PJ

    更新日期:2000-05-01 00:00:00

  • Organization and evolution of brain lipidome revealed by large-scale analysis of human, chimpanzee, macaque, and mouse tissues.

    abstract::Lipids are prominent components of the nervous system. Here we performed a large-scale mass spectrometry-based analysis of the lipid composition of three brain regions as well as kidney and skeletal muscle of humans, chimpanzees, rhesus macaques, and mice. The human brain shows the most distinct lipid composition: 76%...


    pub_type: 杂志文章


    authors: Bozek K,Wei Y,Yan Z,Liu X,Xiong J,Sugimoto M,Tomita M,Pääbo S,Sherwood CC,Hof PR,Ely JJ,Li Y,Steinhauser D,Willmitzer L,Giavalisco P,Khaitovich P

    更新日期:2015-02-18 00:00:00

  • Epimetronomics: m6A Marks the Tempo of Corticogenesis.

    abstract::Yoon et al. (2017) uncover a key role for the m6A RNA mark in regulating the timing of cerebral cortex development in mouse and human. This discovery opens new avenues of exploration into how the epitranscriptome helps orchestrate central nervous system formation. ...


    pub_type: 评论,杂志文章


    authors: Boles NC,Temple S

    更新日期:2017-11-15 00:00:00

  • Parkin: a multipurpose neuroprotective agent?

    abstract::An autosomal recessive juvenile-onset form of Parkinson's disease (AR-JP) is caused by loss-of-function mutations of the parkin gene, which encodes a ubiquitin-protein ligase. Three recent reports demonstrate that parkin can protect neurons from diverse cellular insults, including alpha-synuclein toxicity, proteasomal...


    pub_type: 杂志文章


    authors: Feany MB,Pallanck LJ

    更新日期:2003-04-10 00:00:00

  • Connecting the dots: from actin polymerization to synapse formation.

    abstract::Protrusive behavior of dendritic spines on developing neurons has been previously suggested to mediate the formation of new axodendritic synaptic contacts. A study by Zito et al. in this issue of Neuron links actin polymerization in dendritic spines with the motility that the spines exhibit and the synapses that they ...


    pub_type: 评论,杂志文章


    authors: Dunaevsky A

    更新日期:2004-10-14 00:00:00

  • Synaptic vesicles immunoisolated from rat cerebral cortex contain high levels of glutamate.

    abstract::L-Glutamate is regarded as the major excitatory neurotransmitter in the mammalian CNS. However, whether the released transmitter originates from a cytosolic pool or is discharged from synaptic vesicles by exocytosis (vesicle hypothesis) remains controversial. A problem with the general acceptance of the vesicle hypoth...


    pub_type: 杂志文章


    authors: Burger PM,Mehl E,Cameron PL,Maycox PR,Baumert M,Lottspeich F,De Camilli P,Jahn R

    更新日期:1989-12-01 00:00:00

  • New modules are added to vibrissal premotor circuitry with the emergence of exploratory whisking.

    abstract::Rodents begin to use bilaterally coordinated, rhythmic sweeping of their vibrissae ("whisking") for environmental exploration around 2 weeks after birth. Whether (and how) the vibrissal control circuitry changes after birth is unknown, and the relevant premotor circuitry remains poorly characterized. Using a modified ...


    pub_type: 杂志文章


    authors: Takatoh J,Nelson A,Zhou X,Bolton MM,Ehlers MD,Arenkiel BR,Mooney R,Wang F

    更新日期:2013-01-23 00:00:00

  • Phospholipase C-gamma and phosphoinositide 3-kinase mediate cytoplasmic signaling in nerve growth cone guidance.

    abstract::Expression of rat TrkA in Xenopus spinal neurons confers responsiveness of these neurons to nerve growth factor (NGF) in assays of neuronal survival and growth cone chemotropism. Mutational analysis indicates that coactivation of phospholipase C-gamma (PLC-gamma) and phosphoinositide 3-kinase (PI3-kinase) by specific ...


    pub_type: 杂志文章


    authors: Ming G,Song H,Berninger B,Inagaki N,Tessier-Lavigne M,Poo M

    更新日期:1999-05-01 00:00:00

  • …with Love, from Post to Pre.

    abstract::In this issue of Neuron, Costa et al. (2017) introduce a theoretical framework that predicts the ratio of presynaptic and postsynaptic changes taking place during LTP and LTD and show that these processes co-operate so as to optimize the postsynaptic response statistics. ...


    pub_type: 杂志文章


    authors: Poirazi P,Kastellakis G

    更新日期:2017-09-27 00:00:00

  • A c-Jun dominant negative mutant protects sympathetic neurons against programmed cell death.

    abstract::Sympathetic neurons depend on nerve growth factor (NGF) for survival and die by apoptosis in its absence. We have investigated the pattern of expression of the Jun and Fos family of transcription factors in dying sympathetic neurons using antibodies specific for each family member. When sympathetic neurons are deprive...


    pub_type: 杂志文章


    authors: Ham J,Babij C,Whitfield J,Pfarr CM,Lallemand D,Yaniv M,Rubin LL

    更新日期:1995-05-01 00:00:00