Abstract:
:We provide physiological, pharmacological, and structural evidence that axons of hippocampal principal cells are electrically coupled, with prepotentials or spikelets forming the physiological substrate of electrical coupling as observed in cell somata. Antidromic activation of neighboring axons induced somatic spikelet potentials in neurons of CA3, CA1, and dentate gyrus areas of rat hippocampal slices. Somatic invasion by these spikelets was dependent on the activation of fast Na(+) channels in the postjunctional neuron. Antidromically elicited spikelets were suppressed by gap junction blockers and low intracellular pH. Paired axo-somatic and somato-dendritic recordings revealed that the coupling potentials appeared in the axon before invading the soma and the dendrite. Using confocal laser scanning microscopy we found that putative axons of principal cells were dye coupled. Our data thus suggest that hippocampal neurons are coupled by axo-axonal junctions, providing a novel mechanism for very fast electrical communication.
journal_name
Neuronjournal_title
Neuronauthors
Schmitz D,Schuchmann S,Fisahn A,Draguhn A,Buhl EH,Petrasch-Parwez E,Dermietzel R,Heinemann U,Traub RDdoi
10.1016/s0896-6273(01)00410-xsubject
Has Abstractpub_date
2001-09-13 00:00:00pages
831-40issue
5eissn
0896-6273issn
1097-4199pii
S0896-6273(01)00410-Xjournal_volume
31pub_type
杂志文章相关文献
NEURON文献大全abstract::Painful mechanical stimuli activate multiple peripheral sensory afferent subtypes simultaneously, including nociceptors and low-threshold mechanoreceptors (LTMRs). Using an optogenetic approach, we demonstrate that LTMRs do not solely serve as touch receptors but also play an important role in acute pain signaling. We...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2016.11.027
更新日期:2017-01-04 00:00:00
abstract::Phosphorylation of brain Na+ channels by protein kinase C (PKC) decreases peak Na+ current and slows macroscopic inactivation, but receptor-activated modulation of Na+ currents via the PKC pathway has not been demonstrated. We have examined modulation of Na+ channels by activation of muscarinic receptors in acutely-is...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(00)80125-7
更新日期:1996-05-01 00:00:00
abstract::It has been unclear whether the hippocampus is uniquely important for episodic memory (memory for events that are specific to time and place) or whether the hippocampus is also important for learning and remembering facts (semantic memory). In two studies, we assessed the capacity for semantic memory in patients with ...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(03)00146-6
更新日期:2003-04-10 00:00:00
abstract::Functional neural circuit formation during development involves massive elimination of redundant synapses. In the cerebellum, one-to-one connection from excitatory climbing fiber (CF) to Purkinje cell (PC) is established by elimination of early-formed surplus CFs. This process depends on glutamatergic excitatory input...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2012.02.032
更新日期:2012-04-26 00:00:00
abstract::The combination of brain imaging and genetics promises to identify neural mechanisms underlying complex traits such as cognition and psychiatric disorder. The study by Heck et al. (2014) in this issue of Neuron highlights voltage-gated cation channel activity as a likely link and culprit. ...
journal_title:Neuron
pub_type: 评论,杂志文章
doi:10.1016/j.neuron.2014.02.023
更新日期:2014-03-05 00:00:00
abstract::Experience is a powerful sculptor of developing neural connections. In the primary visual cortex (V1), cortical connections are particularly susceptible to the effects of sensory manipulation during a postnatal critical period. At the molecular level, this activity-dependent plasticity requires the transformation of s...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(02)00966-2
更新日期:2002-10-24 00:00:00
abstract::Among the three human apolipoprotein E (apoE) isoforms, apoE4 increases the risk of Alzheimer's disease (AD). While transporting cholesterol is a primary function, apoE also regulates amyloid-β (Aβ) metabolism, aggregation, and deposition. Although earlier work suggests that different affinities of apoE isoforms to Aβ...
journal_title:Neuron
pub_type: 杂志文章,评审
doi:10.1016/j.neuron.2014.01.045
更新日期:2014-02-19 00:00:00
abstract::Quantitative differences in cadherin activity have been proposed to play important roles in patterning connections between pre- and postsynaptic neurons. However, no examples of such a function have yet been described, and the mechanisms that would allow such differences to direct growth cones to specific synaptic tar...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2008.01.007
更新日期:2008-04-10 00:00:00
abstract::Previous work has hinted that prospective and retrospective coding modes exist in hippocampus. Prospective coding is believed to reflect memory retrieval processes, whereas retrospective coding is thought to be important for memory encoding. Here, we show in rats that separate prospective and retrospective modes exist...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2014.03.013
更新日期:2014-05-07 00:00:00
abstract::Sustained rate-coded signals encode many types of sensory modalities. Some sensory synapses possess specialized ribbon structures, which tether vesicles, to enable high-frequency signaling. However, central synapses lack these structures, yet some can maintain signaling over a wide bandwidth. To analyze the underlying...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2010.10.026
更新日期:2010-11-18 00:00:00
abstract::Analysis of the Drosophila lark gene indicates that it encodes an RNA-binding protein that functions as a regulatory element of the circadian clock output pathway controlling adult eclosion. We now demonstrate that the lark RNA-binding protein oscillates in abundance during the circadian cycle; importantly, the phasin...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(00)80457-2
更新日期:1998-02-01 00:00:00
abstract::Homeostatic signaling systems are thought to interface with the mechanisms of neural plasticity to achieve stable yet flexible neural circuitry. However, the time course, molecular design, and implementation of homeostatic signaling remain poorly defined. Here we demonstrate that a homeostatic increase in presynaptic ...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2006.09.029
更新日期:2006-11-22 00:00:00
abstract::Sensory experience evokes long-lasting changes in neural circuits through activity-dependent gene expression. Ataman et al. (2016) report in Nature that primates evolved novel transcriptional responses to neuronal activity, including induction of musclin/osteocrin (OSTN), which may regulate specialized aspects of prim...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2016.11.024
更新日期:2016-11-23 00:00:00
abstract::Visual experience before eye-opening is not usually thought to have any developmental significance. Here we show that naturalistic visual stimuli presented through unopened eyelids robustly activate neurons in the ferret dorsal lateral geniculate nucleus. Further, dark-rearing prior to natural eye-opening has striking...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(02)01010-3
更新日期:2002-12-05 00:00:00
abstract::Since the early days of research into language and the brain, word meaning was assumed to be processed in specific brain regions, which most modern neuroscientists localize to the left temporal lobe. Here we use event-related fMRI to show that action words referring to face, arm, or leg actions (e.g., to lick, pick, o...
journal_title:Neuron
pub_type: 临床试验,杂志文章
doi:10.1016/s0896-6273(03)00838-9
更新日期:2004-01-22 00:00:00
abstract::Imaging large-scale circuit dynamics is crucial to understanding brain function, but most techniques have a limited depth of field. Here, we describe volumetric functional ultrasound imaging (vfUSI), a platform for brain-wide vfUSI of hemodynamic activity in awake head-fixed mice. We combined a high-frequency 1,024-ch...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2020.09.020
更新日期:2020-12-09 00:00:00
abstract::In this issue of Neuron, Winkowski and Knudsen reveal striking parallels between the attentional systems of the barn owl and the rhesus macaque. The observation of close similarities between the attentional systems of such distantly related organisms strongly suggest that key computational principles are at work. ...
journal_title:Neuron
pub_type: 评论,杂志文章,评审
doi:10.1016/j.neuron.2008.11.006
更新日期:2008-11-26 00:00:00
abstract::Satb2 is a DNA-binding protein that regulates chromatin organization and gene expression. In the developing brain, Satb2 is expressed in cortical neurons that extend axons across the corpus callosum. To assess the role of Satb2 in neurons, we analyzed mice in which the Satb2 locus was disrupted by insertion of a LacZ ...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2007.12.012
更新日期:2008-02-07 00:00:00
abstract::Autism spectrum disorder (ASD) may arise from increased ratio of excitatory to inhibitory neurotransmission in the brain. Many pharmacological treatments have been tested in ASD, but only limited success has been achieved. Here we report that BTBR T(+)Itpr3(tf)/J (BTBR) mice, a model of idiopathic autism, have reduced...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2014.01.016
更新日期:2014-03-19 00:00:00
abstract::K(ATP) channels are large heteromultimeric complexes containing four subunits from the inwardly rectifying K+ channel family (Kir6.2) and four regulatory sulphonylurea receptor subunits from the ATP-binding cassette (ABC) transporter family (SUR1 and SUR2A/B). The molecular basis for interactions between these two unr...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(00)81146-0
更新日期:2000-04-01 00:00:00
abstract::Locomotion is controlled by spinal networks that generate rhythm and coordinate left-right and flexor-extensor patterning. Defined populations of spinal interneurons have been linked to patterning circuits; however, neurons comprising the rhythm-generating kernel have remained elusive. Here, we identify an ipsilateral...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2013.08.015
更新日期:2013-11-20 00:00:00
abstract::There have been several recent studies addressing the genetic architecture of depression. This review serves to take stock of what is known now about the genetics of depression, how it has increased our knowledge and understanding of its mechanisms, and how the information and knowledge can be leveraged to improve the...
journal_title:Neuron
pub_type: 杂志文章,评审
doi:10.1016/j.neuron.2019.03.022
更新日期:2019-04-03 00:00:00
abstract::Transmembrane channel-like (TMC) 1 and 2 are required for the mechanotransduction of mouse inner ear hair cells and localize to the site of mechanotransduction in mouse hair cell stereocilia. However, it remains unclear whether TMC1 and TMC2 are indeed ion channels and whether they can sense mechanical force directly....
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2019.10.017
更新日期:2020-01-22 00:00:00
abstract::Murine and canine narcolepsy can be caused by mutations of the hypocretin (Hcrt) (orexin) precursor or Hcrt receptor genes. In contrast to these animal models, most human narcolepsy is not familial, is discordant in identical twins, and has not been linked to mutations of the Hcrt system. Thus, the cause of human narc...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(00)00058-1
更新日期:2000-09-01 00:00:00
abstract::Modulation of evoked quantal transmitter release by protein kinase C (PKC) was investigated at an identified cholinergic neuro-neuronal synapse of the Aplysia buccal ganglion. Evoked acetylcholine release was increased by a diacylglycerol analog that activates PKC and was decreased by H-7, a blocker of PKC. FLRFamide ...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(90)90087-v
更新日期:1990-10-01 00:00:00
abstract::In uncertain environments, decision-makers must balance two goals: they must "exploit" rewarding options but also "explore" in order to discover rewarding alternatives. Exploring and exploiting necessarily change how the brain responds to identical stimuli, but little is known about how these states, and transitions b...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2017.12.007
更新日期:2018-01-17 00:00:00
abstract::Synchronized oscillatory activity at the gamma frequency (30-70 Hz) is thought to be important for information processing in many sensory systems. Here, I used patch-clamp recordings in neuron pairs in rat olfactory bulb slices to assess the mechanisms underlying such "gamma" activity in the olfactory system. Patterne...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2005.11.038
更新日期:2006-01-19 00:00:00
abstract::Insulin-like growth factor I (IGF-I) is a potent regulator of oligodendrocyte development and myelination in vitro, but its effect on myelination in vivo has never been tested directly. Therefore, we examined brain growth and myelination in a transgenic mouse line that overexpresses IGF-I. By postnatal day 55, when br...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(93)90173-o
更新日期:1993-04-01 00:00:00
abstract::The vertebrate ventral midbrain contains 3-4 x 10(4) dopaminergic neurons that influence motor activity, emotional behavior, and cognition. Recently, glial cell line-derived neurotrophic factor (GDNF) was shown to be a potent survival factor for these dopaminergic neurons in culture. However, many midbrain dopaminergi...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(94)90062-0
更新日期:1994-11-01 00:00:00
abstract::Injection of inositol 1,4,5 trisphosphate (InsP3) into Limulus ventral photoreceptors elevates the concentration of intracellular calcium ions and as a consequence depolarizes the photoreceptor. This InsP3-induced elevation can be inhibited by a prior injection of calcium or InsP3 delivered 1 s earlier. Recovery from ...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(90)90112-s
更新日期:1990-04-01 00:00:00