Abstract:
:Injection of inositol 1,4,5 trisphosphate (InsP3) into Limulus ventral photoreceptors elevates the concentration of intracellular calcium ions and as a consequence depolarizes the photoreceptor. This InsP3-induced elevation can be inhibited by a prior injection of calcium or InsP3 delivered 1 s earlier. Recovery from this inhibition has a half-time of between 1.5 and 5 s at 20 degrees C. Calcium released by InsP3 therefore inhibits further release of calcium from InsP3-sensitive calcium stores. This feedback inhibition may protect the calcium stores from depletion during prolonged bright illumination. Feedback inhibition, rather than periodic depletion of calcium stores, may also underlie the oscillatory bursts of InsP3-induced calcium release that have been observed in many cell types.
journal_name
Neuronjournal_title
Neuronauthors
Payne R,Flores TM,Fein Adoi
10.1016/0896-6273(90)90112-ssubject
Has Abstractpub_date
1990-04-01 00:00:00pages
547-55issue
4eissn
0896-6273issn
1097-4199pii
0896-6273(90)90112-Sjournal_volume
4pub_type
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