Abstract：
:Analysis of the Drosophila lark gene indicates that it encodes an RNA-binding protein that functions as a regulatory element of the circadian clock output pathway controlling adult eclosion. We now demonstrate that the lark RNA-binding protein oscillates in abundance during the circadian cycle; importantly, the phasing of the lark rhythm is consistent with gene-dosage studies, which indicate that the protein behaves as a repressor molecule. The lark protein rhythm persists in constant conditions (continuous darkness and constant temperature) and is eliminated by period gene null mutations, confirming that it is under clock control and suggesting that it acts as an output mechanism that mediates the temporal regulation of adult eclosion. We also show that lark protein oscillates in abundance within a defined group of neuropeptide (CCAP) -containing neurons of the ventral nervous system (VNS), which in other insects are thought to comprise cellular elements of the clock output pathway regulating eclosion.
journal_name
Neuronjournal_title
Neuronauthors
McNeil GP,Zhang X,Genova G,Jackson FRdoi
10.1016/s0896-6273(00)80457-2subject
Has Abstractpub_date
1998-02-01 00:00:00pages
297-303issue
2eissn
0896-6273issn
1097-4199pii
S0896-6273(00)80457-2journal_volume
20pub_type
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