Abstract:
:The structural plasticity of dendritic spines is considered to be essential for various forms of synaptic plasticity, learning, and memory. The process is mediated by a complex signaling network consisting of numerous species of molecules. Furthermore, the spatiotemporal dynamics of the biochemical signaling are regulated in a complicated manner because of geometrical restrictions from the unique morphology of the dendritic branches and spines. Recent advances in optical techniques have enabled the exploration of the spatiotemporal aspects of the signal regulations in spines and dendrites and have provided many insights into the principle of the biochemical computation that underlies spine structural plasticity.
journal_name
Neuronjournal_title
Neuronauthors
Nishiyama J,Yasuda Rdoi
10.1016/j.neuron.2015.05.043subject
Has Abstractpub_date
2015-07-01 00:00:00pages
63-75issue
1eissn
0896-6273issn
1097-4199pii
S0896-6273(15)00482-1journal_volume
87pub_type
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