Abstract:
:Extrasynaptic actions of glutamate are limited by high-affinity transporters expressed by perisynaptic astroglial processes (PAPs): this helps maintain point-to-point transmission in excitatory circuits. Memory formation in the brain is associated with synaptic remodeling, but how this affects PAPs and therefore extrasynaptic glutamate actions is poorly understood. Here, we used advanced imaging methods, in situ and in vivo, to find that a classical synaptic memory mechanism, long-term potentiation (LTP), triggers withdrawal of PAPs from potentiated synapses. Optical glutamate sensors combined with patch-clamp and 3D molecular localization reveal that LTP induction thus prompts spatial retreat of astroglial glutamate transporters, boosting glutamate spillover and NMDA-receptor-mediated inter-synaptic cross-talk. The LTP-triggered PAP withdrawal involves NKCC1 transporters and the actin-controlling protein cofilin but does not depend on major Ca2+-dependent cascades in astrocytes. We have therefore uncovered a mechanism by which a memory trace at one synapse could alter signal handling by multiple neighboring connections.
journal_name
Neuronjournal_title
Neuronauthors
Henneberger C,Bard L,Panatier A,Reynolds JP,Kopach O,Medvedev NI,Minge D,Herde MK,Anders S,Kraev I,Heller JP,Rama S,Zheng K,Jensen TP,Sanchez-Romero I,Jackson CJ,Janovjak H,Ottersen OP,Nagelhus EA,Oliet SHR,Stewardoi
10.1016/j.neuron.2020.08.030subject
Has Abstractpub_date
2020-12-09 00:00:00pages
919-936.e11issue
5eissn
0896-6273issn
1097-4199pii
S0896-6273(20)30661-9journal_volume
108pub_type
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