Peri-Synaptic Glia Recycles Brain-Derived Neurotrophic Factor for LTP Stabilization and Memory Retention.

abstract：:We have examined the long-term effects of notochord ablation at chick stages 9-10 on formation of the floor plate and motor neurons. Although missing or reduced 2 days postablation, the floor plate and motor neurons were morphologically normal by 4 postoperative days. When isolated whole or ventral, but not lateral, n...

journal_title：Neuron

authors： Artinger KB,Bronner-Fraser M

更新日期：1993-12-01 00:00:00

abstract：:Sensory systems change their sensitivity based on recent stimuli to adjust their response range to the range of inputs and to predict future sensory input. Here, we report the presence of retinal ganglion cells that have antagonistic plasticity, showing central adaptation and peripheral sensitization. Ganglion cell re...

journal_title：Neuron

authors： Kastner DB,Baccus SA

更新日期：2013-08-07 00:00:00

abstract：:Primary familial brain calcification (PFBC) is a genetically heterogeneous disorder characterized by bilateral calcifications in the basal ganglia and other brain regions. The genetic basis of this disorder remains unknown in a significant portion of familial cases. Here, we reported a recessive causal gene, MYORG, fo...

journal_title：Neuron

authors： Yao XP,Cheng X,Wang C,Zhao M,Guo XX,Su HZ,Lai LL,Zou XH,Chen XJ,Zhao Y,Dong EL,Lu YQ,Wu S,Li X,Fan G,Yu H,Xu J,Wang N,Xiong ZQ,Chen WJ

更新日期：2018-06-27 00:00:00

abstract：:Brandon et al. (2014) show that the formation of place cell representations in new environments is preserved under septal inactivation, and is thus likely independent of the hippocampal theta rhythm and, by implication, the firing of entorhinal grid cells and the process of path integration. ...

journal_title：Neuron

authors： Hayman R,Burgess N

更新日期：2014-05-21 00:00:00

abstract：:Diphosphoinositol-pentakisphosphate (InsP7) and bis-diphosphoinositol tetrakisphosphate (InsP8) possess pyrophosphate bonds. InsP7 is formed from inositol hexakisphosphate (InsP6) by recently identified InsP6 kinases designated InsP6K1 and InsP6K2. We now report the identification, cloning, and characterization of a n...

journal_title：Neuron

authors： Luo HR,Saiardi A,Nagata E,Ye K,Yu H,Jung TS,Luo X,Jain S,Sawa A,Snyder SH

更新日期：2001-08-16 00:00:00

abstract：:The eye often leads the way in the development of novel strategies for treating neurodegenerative disorders. Here, we highlight an exciting new study examining the potential for reactivating endogenous repair mechanisms and enabling the mammalian retina to repair itself. ...

journal_title：Neuron

authors： Pearson RA,Ali RR

更新日期：2018-11-07 00:00:00

abstract：:Nearly 25 years ago, the shared interests of psychologists and biologists in understanding the neural basis of social behavior led to the inception of social neuroscience. In the past decade, this field has exploded, in large part due to the infusion of studies that use fMRI. At the same time, tensions have arisen abo...

journal_title：Neuron

authors： Stanley DA,Adolphs R

更新日期：2013-10-30 00:00:00

abstract：:Retinal specializations such as cone-photoreceptor opsin-expression gradients, as found in several vertebrate species, are intuitively considered detrimental to color vision. In mice, the majority of cones coexpress both "blue" and "green" opsin. The coexpression ratio changes along the dorsoventral axis, resulting in...

journal_title：Neuron

authors： Chang L,Breuninger T,Euler T

更新日期：2013-02-06 00:00:00

abstract：:Recent binding studies in the central nervous system and other tissues provide evidence that the mammalian bombesin-like peptides, gastrin-releasing peptide (GRP) and neuromedin-B (NMB), exert their numerous physiological effects through at least two different receptors. We describe the structure and expression of a c...

journal_title：Neuron

authors： Wada E,Way J,Shapira H,Kusano K,Lebacq-Verheyden AM,Coy D,Jensen R,Battery J

更新日期：1991-03-01 00:00:00

abstract：:Elevation of cAMP can overcome myelin inhibitors to encourage regeneration of the CNS. We show that a consequence of elevated cAMP is the synthesis of polyamines, resulting from an up-regulation of Arginase I, a key enzyme in their synthesis. Inhibiting polyamine synthesis blocks the cAMP effect on regeneration. Eithe...

journal_title：Neuron

authors： Cai D,Deng K,Mellado W,Lee J,Ratan RR,Filbin MT

更新日期：2002-08-15 00:00:00

abstract：:The presynaptic active zone is composed of a protein network that contains ELKS2alpha (a.k.a. CAST) as a central component. Here we demonstrate that in mice, deletion of ELKS2alpha caused a large increase in inhibitory, but not excitatory, neurotransmitter release, and potentiated the size, but not the properties, of ...

journal_title：Neuron

authors： Kaeser PS,Deng L,Chávez AE,Liu X,Castillo PE,Südhof TC

更新日期：2009-10-29 00:00:00

abstract：UNLABELLED:Developmental dyslexia is a reading disorder, yet deficits also manifest in the magnocellular-dominated dorsal visual system. Uncertainty about whether visual deficits are causal or consequential to reading disability encumbers accurate identification and appropriate treatment of this common learning disabil...

journal_title：Neuron

authors： Olulade OA,Napoliello EM,Eden GF

更新日期：2013-07-10 00:00:00

abstract：:Olfactory receptor neurons (ORNs) do not express the typical neuronal intermediate filament proteins (IFPs), the neurofilament triplet proteins. Immunocytochemical evidence shows that ORNs coexpress vimentin and peripherin but distribute them differently. Specifically, ORNs contain vimentin in dendrites, cell bodies, ...

journal_title：Neuron

authors： Gorham JD,Ziff EB,Baker H

更新日期：1991-09-01 00:00:00

abstract：:GABARAP recognizes and binds the gamma2 subunit of the GABA(A) receptor, interacts with microtubules and the N-ethyl maleimide sensitive factor, and is proposed to function in GABA(A) receptor trafficking and postsynaptic localization. We have determined the crystal structure of human GABARAP at 1.6 A resolution. The ...

journal_title：Neuron

authors： Coyle JE,Qamar S,Rajashankar KR,Nikolov DB

更新日期：2002-01-03 00:00:00

abstract：:Since the inflammatory process develops after transplantation to the brain, we sought to determine the presence of cytokines following a surgical trauma to the brain of an adult mouse. We report the early and marked presence of tumor necrosis factor-alpha and interleukin-1 alpha in neuronal somata of the striatum foll...

journal_title：Neuron

authors： Tchelingerian JL,Quinonero J,Booss J,Jacque C

更新日期：1993-02-01 00:00:00

abstract：:Much recent discussion about the origin of Parkinsonian symptoms has centered around the idea that they arise with the increase of beta frequency waves in the EEG. This activity may be closely related to an oscillation between subthalamic nucleus (STN) and globus pallidus. Since STN is the target of deep brain stimula...

journal_title：Neuron

authors： Li Q,Ke Y,Chan DC,Qian ZM,Yung KK,Ko H,Arbuthnott GW,Yung WH

更新日期：2012-12-06 00:00:00

abstract：:Synapse-to-nucleus signaling leading to CREB-mediated transcription is important for neuronal plasticity. Nuclear CREB phosphorylation at Ser133 allows convergence of multiple kinase pathways driven by neuronal activity and links them to transcriptional activation. But, can various pathways share a common effector mec...

journal_title：Neuron

authors： Deisseroth K,Tsien RW

更新日期：2002-04-11 00:00:00

abstract：:The enteric nervous system (ENS) in vertebrates is derived mainly from vagal neural crest cells that enter the foregut and colonize the entire wall of the gastrointestinal tract. Failure to completely colonize the gut results in the absence of enteric ganglia (Hirschsprung's disease). Two signaling systems mediated by...

journal_title：Neuron

authors： Barlow A,de Graaff E,Pachnis V

更新日期：2003-12-04 00:00:00

abstract：:Retinal bipolar cells are essential to the transmission of light information. Although bipolar cell dysfunction can result in blindness, little is known about the factors required for bipolar cell development and functional maturation. The basic helix-loop-helix (bHLH) transcription factor Bhlhb4 was found to be expre...

journal_title：Neuron

authors： Bramblett DE,Pennesi ME,Wu SM,Tsai MJ

更新日期：2004-09-16 00:00:00

abstract：:Autism spectrum disorder (ASD) is a heritable, common neurodevelopmental disorder with diverse genetic causes. Several studies have implicated protein synthesis as one among several of its potential convergent mechanisms. We originally identified Janus kinase and microtubule-interacting protein 1 (JAKMIP1) as differen...

journal_title：Neuron

authors： Berg JM,Lee C,Chen L,Galvan L,Cepeda C,Chen JY,Peñagarikano O,Stein JL,Li A,Oguro-Ando A,Miller JA,Vashisht AA,Starks ME,Kite EP,Tam E,Gdalyahu A,Al-Sharif NB,Burkett ZD,White SA,Fears SC,Levine MS,Wohlschlegel

更新日期：2015-12-16 00:00:00

abstract：:AMPA but not kainate produces a rapidly desensitizing response in mouse hippocampal neurons. The characteristic action of these agonists appears to arise from activation of a single receptor with active and desensitized states, for which AMPA and kainate have different relative affinity. The equilibrium potency of a s...

journal_title：Neuron

authors： Patneau DK,Mayer ML

更新日期：1991-05-01 00:00:00

abstract：:Real-time activity measurements of genetically identified neuroendocrine vasopressin neurons show they can anticipate osmotic challenges. In this issue of Neuron, Mandelblat-Cerf et al. (2017) show that correlating these results with ongoing behavior and plasma osmolality points to the existence of brain networks that...

journal_title：Neuron

authors： Watts AG

更新日期：2017-01-04 00:00:00

abstract：:While nerve growth factor (NGF) is best known for its trophic functions, recent experiments indicate that it can also cause cell death during development by activating the neurotrophin receptor p75. We now identify microglial cells as the source of NGF as a killing agent in the developing eye. When the retina is separ...

journal_title：Neuron

authors： Frade JM,Barde YA

更新日期：1998-01-01 00:00:00

abstract：:The targeting of sensory afferent neurons in the leech CNS occurs in two discrete steps that are mediated via different carbohydrate recognitions, as shown by molecular perturbations of cultured embryos. A constitutive carbohydrate marker that is generic to all of these neurons mediates their initial defasciculation a...

journal_title：Neuron

authors： Song J,Zipser B

更新日期：1995-03-01 00:00:00

abstract：:The Prx gene in Schwann cells encodes L- and S-periaxin, two abundant PDZ domain proteins thought to have a role in the stabilization of myelin in the peripheral nervous system (PNS). Mice lacking a functional Prx gene assemble compact PNS myelin. However, the sheath is unstable, leading to demyelination and reflex be...

journal_title：Neuron

authors： Gillespie CS,Sherman DL,Fleetwood-Walker SM,Cottrell DF,Tait S,Garry EM,Wallace VC,Ure J,Griffiths IR,Smith A,Brophy PJ

更新日期：2000-05-01 00:00:00

abstract：:Sanders et al. (2014) demonstrate in this issue of Neuron that the natively unfolded protein tau can propagate indefinitely in distinct stable strains, therefore supporting the general idea that tau has prion-like properties, with implications for Alzheimer's disease and other tauopathies. ...

journal_title：Neuron

authors： Hyman BT

更新日期：2014-06-18 00:00:00

abstract：:We recently applied multiplexed seqFISH to profile expressions of hundreds of genes at the single-cell level in situ (Shah et al., 2016) and provided a map of spatial heterogeneity within each subregion, reconciling previously contradictory descriptions of CA1 at lower spatial resolutions. The accompanying Matters Ari...

journal_title：Neuron

authors： Shah S,Lubeck E,Zhou W,Cai L

更新日期：2017-05-17 00:00:00

abstract：:We have identified the species of K+ channel that underlies the neuronal M-current in rat sympathetic ganglion cells. The channels were kinetically and pharmacologically defined using outside-out and cell-attached patches. They exhibited multiple conductance levels, predominantly 3-9 pS. Their slow gating in response ...

journal_title：Neuron

authors： Stansfeld CE,Marsh SJ,Gibb AJ,Brown DA

更新日期：1993-04-01 00:00:00

abstract：:Although associative learning has been localized to specific brain areas in many animals, identifying the underlying synaptic processes in vivo has been difficult. Here, we provide the first demonstration of long-term synaptic plasticity at the output site of the Drosophila mushroom body. Pairing an odor with activati...

journal_title：Neuron

authors： Hige T,Aso Y,Modi MN,Rubin GM,Turner GC

更新日期：2015-12-02 00:00:00

abstract：:The neurotrophic proteins BDNF and NGF are related in their primary structures, and both have high- and low-affinity receptors on their responsive neurons. In this study, we investigate the extent to which these receptors can discriminate between BDNF and NGF. We found that a 1000-fold excess of the heterologous ligan...

journal_title：Neuron

authors： Rodriguez-Tébar A,Dechant G,Barde YA

更新日期：1990-04-01 00:00:00