Abstract：
:Currently, there are no medications that effectively treat the core symptoms of Autism Spectrum Disorder (ASD). We recently found that the bacterial species Lactobacillus (L.) reuteri reverses social deficits in maternal high-fat-diet offspring. However, whether the effect of L. reuteri on social behavior is generalizable to other ASD models and its mechanism(s) of action remains unknown. Here, we found that treatment with L. reuteri selectively rescues social deficits in genetic, environmental, and idiopathic ASD models. Interestingly, the effects of L. reuteri on social behavior are not mediated by restoring the composition of the host's gut microbiome, which is altered in all of these ASD models. Instead, L. reuteri acts in a vagus nerve-dependent manner and rescues social interaction-induced synaptic plasticity in the ventral tegmental area of ASD mice, but not in oxytocin receptor-deficient mice. Collectively, treatment with L. reuteri emerges as promising non-invasive microbial-based avenue to combat ASD-related social dysfunction.
journal_name
Neuronjournal_title
Neuronauthors
Sgritta M,Dooling SW,Buffington SA,Momin EN,Francis MB,Britton RA,Costa-Mattioli Mdoi
10.1016/j.neuron.2018.11.018subject
Has Abstractpub_date
2019-01-16 00:00:00pages
246-259.e6issue
2eissn
0896-6273issn
1097-4199pii
S0896-6273(18)31009-2journal_volume
101pub_type
杂志文章相关文献
NEURON文献大全abstract：:Visual information reaches the brain by way of a fine cable, the optic nerve. The million or so axons in the optic nerve represent an information bottleneck in the visual pathway-where the fewest number of neurons convey the visual scene. It has long been thought that to make the most of the optic nerve's limited capa...
journal_title：Neuron
pub_type： 评论,杂志文章,评审
doi：10.1016/j.neuron.2005.04.018
更新日期：2005-05-05 00:00:00
abstract：:We examined context-dependent encoding of speech in children with and without developmental dyslexia by measuring auditory brainstem responses to a speech syllable presented in a repetitive or variable context. Typically developing children showed enhanced brainstem representation of features related to voice pitch in...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2009.10.006
更新日期：2009-11-12 00:00:00
abstract：:GABA(B) (gamma-aminobutyric acid type B) receptors are important for keeping neuronal excitability under control. Cloned GABA(B) receptors do not show the expected pharmacological diversity of native receptors and it is unknown whether they contribute to pre- as well as postsynaptic functions. Here, we demonstrate tha...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/s0896-6273(01)00345-2
更新日期：2001-07-19 00:00:00
abstract：:The neural circuits governing vital behaviors, such as respiration and locomotion, are comprised of discrete neuronal populations residing within the brainstem and spinal cord. Work over the past decade has provided a fairly comprehensive understanding of the developmental pathways that determine the identity of major...
journal_title：Neuron
pub_type： 杂志文章,评审
doi：10.1016/j.neuron.2013.09.020
更新日期：2013-10-02 00:00:00
abstract：:Charybdotoxin (CTX) blocks high conductance Ca(2+)-activated K+ channels by binding to a receptor site in the externally facing "mouth." Toxin bound to the channel can be destabilized from its site by K+ entering the channel from the opposite, internal, solution. By analyzing point mutants of CTX expressed in E. coli,...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/0896-6273(92)90169-e
更新日期：1992-08-01 00:00:00
abstract：:Notch1 has been shown to induce glia in the peripheral nervous system. However, it has not been known whether Notch can direct commitment to glia from multipotent progenitors of the central nervous system. Here we present evidence that activated Notch1 and Notch3 promotes the differentiation of astroglia from the rat ...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/s0896-6273(01)00179-9
更新日期：2001-01-01 00:00:00
abstract：:The signaling mechanisms that control the survival of CNS neurons are poorly understood. Here we show that, in contrast to PNS neurons, the survival of purified postnatal rat retinal ganglion cells (RGCs) in vitro is not promoted by peptide trophic factors unless their intracellular cAMP is increased pharmacologically...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/0896-6273(95)90172-8
更新日期：1995-10-01 00:00:00
abstract：:The brain is a vulnerable metabolic organ and must adapt to different fuel conditions to sustain function. Nerve terminals are a locus of this vulnerability, but how they regulate ATP synthesis as fuel conditions vary is unknown. We show that synapses can switch from glycolytic to oxidative metabolism, but to do so, t...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2019.11.020
更新日期：2020-02-19 00:00:00
abstract：:The behavioral expression of fear ranges from active, cognitive responses to passive, freezing-like reactions. In this issue of Neuron, Gozzi, Jain, and colleagues suggest that neurons in the central amygdala orchestrate output signals toward either the brainstem or cholinergic basal forebrain and thereby can shift fe...
journal_title：Neuron
pub_type： 评论,杂志文章
doi：10.1016/j.neuron.2010.08.009
更新日期：2010-08-26 00:00:00
abstract：:Excitotoxic cell death stimulated by quinolinic acid injection into the striatum has a long history of "mimicking" many aspects of motor, behavioral, and neurochemical changes observed in Huntington's disease patients. In this issue of Neuron, provide insight into the role of NMDA receptors in the cell-specific excito...
journal_title：Neuron
pub_type： 评论,杂志文章
doi：10.1016/s0896-6273(02)00631-1
更新日期：2002-03-14 00:00:00
abstract：:In this issue of Neuron, Orbán et al. (2016) test whether the brain represents probabilities by sampling: do neurons interpret the world by generating causal explanations of sense data and quickly sample different interpretations over time? Orbán et al. (2016) find agreement between this model's predictions and neural...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2016.10.007
更新日期：2016-10-19 00:00:00
abstract：:Successful visual navigation requires a sense of the geometry of the local environment. How do our brains extract this information from retinal images? Here we visually presented scenes with all possible combinations of five scene-bounding elements (left, right, and back walls; ceiling; floor) to human subjects during...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2019.04.014
更新日期：2019-07-03 00:00:00
abstract：:Application of Clostridium difficile toxin B, an inhibitor of the Rho family of GTPases, at the Aplysia sensory to motor neuron synapse blocks long-term facilitation and the associated growth of new sensory neuron varicosities induced by repeated pulses of serotonin (5-HT). We have isolated cDNAs encoding Aplysia Rho,...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2005.01.044
更新日期：2005-03-24 00:00:00
abstract：UNLABELLED:Developmental dyslexia is a reading disorder, yet deficits also manifest in the magnocellular-dominated dorsal visual system. Uncertainty about whether visual deficits are causal or consequential to reading disability encumbers accurate identification and appropriate treatment of this common learning disabil...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2013.05.002
更新日期：2013-07-10 00:00:00
abstract：:The apical tuft of layer 5 pyramidal neurons is innervated by a large number of inhibitory inputs with unknown functions. Here, we studied the functional consequences and underlying molecular mechanisms of apical inhibition on dendritic spike activity. Extracellular stimulation of layer 1, during blockade of glutamate...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2006.04.019
更新日期：2006-05-18 00:00:00
abstract：:Ultrasound has received widespread attention as an emerging technology for targeted, non-invasive neuromodulation based on its ability to evoke electrophysiological and motor responses in animals. However, little is known about the spatiotemporal pattern of ultrasound-induced brain activity that could drive these resp...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2018.05.009
更新日期：2018-06-06 00:00:00
abstract：:Hippocampal pyramidal cells can be divided into place cells, which fire action potentials when an animal is in specific locations, and silent cells, which are not spatially selective. In this issue of Neuron, Epsztein et al. find intracellular differences between place and silent cells by using whole-cell recordings i...
journal_title：Neuron
pub_type： 评论,杂志文章
doi：10.1016/j.neuron.2011.03.015
更新日期：2011-04-14 00:00:00
abstract：:Long non-coding RNAs (lncRNAs) are a diverse and poorly conserved category of transcripts that have expanded greatly in primates, particularly in the brain. We identified an lncRNA, which has acquired 16 microRNA response elements for miR-143-3p in the Catarrhini branch of primates. This lncRNA, termed LncND (neurodev...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2016.05.005
更新日期：2016-06-15 00:00:00
abstract：:We have investigated the cell cycle-related mechanisms that lead to the emergence of primate areas 17 and 18. These areas are characterized by striking differences in cytoarchitectonics and neuron number. We show in vivo that (1) area 17 precursors of supragranular neurons exhibit a shorter cell cycle duration, a redu...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2005.06.032
更新日期：2005-08-04 00:00:00
abstract：:Using high resolution capacitance measurements, we have characterized an ultrafast component of transmitter release in ribbon-type synaptic terminals of retinal bipolar neurons. During depolarization, capacitance increases to a plateau of approximately 30 fF with a time constant of approximately 1.5 ms. When not limit...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/s0896-6273(00)80254-8
更新日期：1996-12-01 00:00:00
abstract：:Spinocerebellar ataxia type 1 (SCA1), due to the expansion of a polyglutamine repeat within the ubiquitously expressed Ataxin-1 protein, leads to the premature degeneration of Purkinje cells (PCs), the cause of which is poorly understood. Here, we identified the unique proteomic signature of Sca1(154Q/2Q) PCs at an ea...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2015.11.033
更新日期：2016-01-06 00:00:00
abstract：:Biochemical studies suggest that syntaxin 1A participates in multiple protein-protein interactions in the synaptic terminal, but the in vivo significance of these interactions is poorly understood. We used a targeted mutagenesis approach to eliminate specific syntaxin binding interactions and demonstrate that Drosophi...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/s0896-6273(00)80811-9
更新日期：1999-07-01 00:00:00
abstract：:In the olfactory bulb of vertebrates or the homologous antennal lobe of insects, odor quality is represented by stereotyped patterns of neuronal activity that are reproducible within and between individuals. Using optical imaging to monitor synaptic activity in the Drosophila antennal lobe, we show here that classical...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/s0896-6273(04)00217-x
更新日期：2004-05-13 00:00:00
abstract：:Given that cocaine induces neuroadaptations through regulation of gene expression, we investigated whether chromatin remodeling at specific gene promoters may be a key mechanism. We show that cocaine induces specific histone modifications at different gene promoters in striatum, a major neural substrate for cocaine's ...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2005.09.023
更新日期：2005-10-20 00:00:00
abstract：:As a means to automate the three-dimensional histological analysis of brain tissue, we demonstrate the use of femtosecond laser pulses to iteratively cut and image fixed as well as fresh tissue. Cuts are accomplished with 1 to 10 microJ pulses to ablate tissue with micron precision. We show that the permeability, immu...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/s0896-6273(03)00370-2
更新日期：2003-07-03 00:00:00
abstract：:In this issue of Neuron, Holz et al. (2019) show that the synaptic protein Homer1a switches mGluR5 signaling to increase AMPA receptor activity for the rapid antidepressant actions of sleep deprivation. ...
journal_title：Neuron
pub_type： 评论,杂志文章
doi：10.1016/j.neuron.2019.10.003
更新日期：2019-10-23 00:00:00
abstract：:Nucleus accumbens dopamine is known to play a role in motivational processes, and dysfunctions of mesolimbic dopamine may contribute to motivational symptoms of depression and other disorders, as well as features of substance abuse. Although it has become traditional to label dopamine neurons as "reward" neurons, this...
journal_title：Neuron
pub_type： 杂志文章,评审
doi：10.1016/j.neuron.2012.10.021
更新日期：2012-11-08 00:00:00
abstract：:Rapid, experience-dependent plasticity in developing visual cortex is thought to be competitive. After monocular visual deprivation, the reduction in response of binocular neurons to one eye is matched by a corresponding increase to the other. Chronic optical imaging in mice deficient in TNFalpha reveals the normal in...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2008.04.023
更新日期：2008-06-12 00:00:00
abstract：:The production of new neurons in the adult hippocampus is exquisitely regulated, and alterations in this process may underlie both normal and pathological hippocampal function. In this issue of Neuron, Tozuka et al. describe electrophysiological recordings that target proliferating progenitor cells in adult mouse hipp...
journal_title：Neuron
pub_type： 评论,杂志文章
doi：10.1016/j.neuron.2005.08.029
更新日期：2005-09-15 00:00:00
abstract：:We report that EphB receptors direct unique axonal behaviors required for mapping the dorsal-ventral (D-V) retinal axis along the lateral-medial (L-M) axis of the superior colliculus (SC). EphBs are expressed in a D-V gradient, ephrin-B1 in a L-M gradient in SC, and ephrin-B3 at its midline. EphBs and ephrin-Bs are ex...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/s0896-6273(02)00799-7
更新日期：2002-08-01 00:00:00
