Abstract：
:Using high resolution capacitance measurements, we have characterized an ultrafast component of transmitter release in ribbon-type synaptic terminals of retinal bipolar neurons. During depolarization, capacitance increases to a plateau of approximately 30 fF with a time constant of approximately 1.5 ms. When not limited by activation kinetics of calcium current, the small pool is depleted even faster, with a time constant of 0.5 ms. After the ultrafast pool is depleted, capacitance rises with a slower time constant of approximately 300 ms. EGTA (5 mM) depresses the slower capacitance rise but leaves the ultrafast phase intact. BAPTA (5 mM) depresses both components of exocytosis. With paired-pulse stimulation, the ultrafast pool recovers from depletion with a time constant of approximately 4 s. The ultrafast component may represent fusion of docked vesicles at the base of the synaptic ribbon, while the slower component represents more distal vesicles on the ribbon.
journal_name
Neuronjournal_title
Neuronauthors
Mennerick S,Matthews Gdoi
10.1016/s0896-6273(00)80254-8subject
Has Abstractpub_date
1996-12-01 00:00:00pages
1241-9issue
6eissn
0896-6273issn
1097-4199pii
S0896-6273(00)80254-8journal_volume
17pub_type
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