Interaction between GRIP and liprin-alpha/SYD2 is required for AMPA receptor targeting.

abstract：:Short-term augmentation of synaptic transmission at sensory neuron synapses of Aplysia contributes to behavioral sensitization and is one of the current models for a cellular mechanism of learning. This neuromodulatory process, mediated at least in part by the facilitatory neurotransmitter serotonin (5-HT) acting thro...

journal_title：Neuron

authors： Klein M

更新日期：1994-07-01 00:00:00

abstract：:Much is known about the functions and properties of neuronal dendrites, but rarely has dendritic activation been monitored while the dendrite performs a computational task. In this issue of Neuron, Bollmann and Engert demonstrate that different regions of a dendrite in the tadpole optic tectum are tuned to stimuli in ...

journal_title：Neuron

authors： Waters J

更新日期：2009-03-26 00:00:00

abstract：:Elucidating the molecular mechanisms underlying quantitative neurocognitive phenotypes will further our understanding of the brain's structural and functional architecture and advance the diagnosis and treatment of the psychiatric disorders that these traits underlie. Although many neurocognitive traits are highly her...

journal_title：Neuron

authors： Congdon E,Poldrack RA,Freimer NB

更新日期：2010-10-21 00:00:00

abstract：:The motor symptoms of Parkinson's disease (PD) are thought to stem from an imbalance in the activity of striatal direct- and indirect-pathway spiny projection neurons (SPNs). Disease-induced alterations in the activity of networks controlling SPNs could contribute to this imbalance. One of these networks is anchored b...

journal_title：Neuron

authors： Tanimura A,Du Y,Kondapalli J,Wokosin DL,Surmeier DJ

更新日期：2019-02-06 00:00:00

abstract：:Postlingually deaf subjects learn the meaning of sounds after cochlear implantation by forming new associations between sounds and their sources. Implants generate coarse frequency responses, preventing place-coding fine enough to discriminate sounds with similar temporal characteristics, e.g., buck/duck. This limitat...

journal_title：Neuron

authors： Giraud AL,Price CJ,Graham JM,Truy E,Frackowiak RS

更新日期：2001-06-01 00:00:00

abstract：:How a single fertilized cell generates diverse neuronal populations has been a fundamental biological problem since the 19(th) century. Classical histological methods revealed that postmitotic neurons are produced in a precise temporal and spatial order from germinal cells lining the cerebral ventricles. In the 20(th)...

journal_title：Neuron

authors： Breunig JJ,Haydar TF,Rakic P

更新日期：2011-05-26 00:00:00

abstract：:We describe the extent to which presynaptic structures at the embryonic neuromuscular junction of Drosophila can form in mutants where development of postsynaptic somatic muscles is affected. Although twist mutant embryos lack mesoderm, motor axons still grow out of the CNS and form morphologically normal presynaptic ...

journal_title：Neuron

authors： Prokop A,Landgraf M,Rushton E,Broadie K,Bate M

更新日期：1996-10-01 00:00:00

abstract：:The fields of neuroscience and artificial intelligence (AI) have a long and intertwined history. In more recent times, however, communication and collaboration between the two fields has become less commonplace. In this article, we argue that better understanding biological brains could play a vital role in building i...

journal_title：Neuron

authors： Hassabis D,Kumaran D,Summerfield C,Botvinick M

更新日期：2017-07-19 00:00:00

abstract：:Quaternary ammonium (QA) compounds inhibit K+ conductance by entering and occluding the open pore of voltage-activated K+ channels. We characterized the effects of a series of alkyl-triethylammonium blockers on the Shaker K+ channel and tested them on a series of site-directed mutants of the channel protein in order t...

journal_title：Neuron

authors： Choi KL,Mossman C,Aubé J,Yellen G

更新日期：1993-03-01 00:00:00

abstract：:We recorded from single neurons in the hippocampus and entorhinal cortex (EC) of rats to investigate the role of these structures in navigation and memory representation. Our results revealed two novel phenomena: first, many cells in CA1 and the EC fired at significantly different rates when the animal was in the same...

journal_title：Neuron

authors： Frank LM,Brown EN,Wilson M

更新日期：2000-07-01 00:00:00

abstract：:A critical feature of neural networks is that they balance excitation and inhibition to prevent pathological dysfunction. How this is achieved is largely unknown, although deficits in the balance contribute to many neurological disorders. We show here that a microRNA (miR-101) is a key orchestrator of this essential f...

journal_title：Neuron

authors： Lippi G,Fernandes CC,Ewell LA,John D,Romoli B,Curia G,Taylor SR,Frady EP,Jensen AB,Liu JC,Chaabane MM,Belal C,Nathanson JL,Zoli M,Leutgeb JK,Biagini G,Yeo GW,Berg DK

更新日期：2016-12-21 00:00:00

abstract：:The study of patients with brain lesions has made major historical contributions to cognitive neuroscience. Here I argue for an increased investment in modern lesion mapping, complementing fMRI studies and laying the conceptual and analytic foundations for future techniques that could experimentally manipulate human b...

journal_title：Neuron

authors： Adolphs R

更新日期：2016-06-15 00:00:00

abstract：:In the developing mammalian retina, spontaneous waves of action potentials are present in the ganglion cell layer weeks before vision. These waves are known to be generated by a synaptically connected network of amacrine cells and retinal ganglion cells, and exhibit complex spatiotemporal patterns, characterized by sh...

journal_title：Neuron

authors： Feller MB,Butts DA,Aaron HL,Rokhsar DS,Shatz CJ

更新日期：1997-08-01 00:00:00

abstract：:Social group dynamics are highly complex. In this issue of Neuron, Anpilov et al. use a novel wireless optogenetic device to demonstrate that the repeated stimulation of oxytocin neurons modulates pro-social and agonistic behaviors in a time- and context-dependent manner. ...

journal_title：Neuron

authors： Maltese F,Papaleo F

更新日期：2020-08-19 00:00:00

abstract：:In this issue of Neuron, McGinty et al. (2013) report that the activity of cue-responsive neurons in the rat nucleus accumbens predicts the vigor of the subsequent approach movement. The characterization of this network state between motivation and action lends novel mechanistic insight to a spectrum of cue-elicited b...

journal_title：Neuron

authors： Catanese J,van der Meer M

更新日期：2013-06-05 00:00:00

abstract：:In this issue of Neuron, a study by Baumgartner et al. investigates the influence of oxytocin on trust behavior and its neural mechanisms. The authors report that, following breaches of trust, oxytocin facilitates prosocial behavior while modulating neural signals in the amygdala and caudate nucleus. The findings have...

journal_title：Neuron

authors： Delgado MR

更新日期：2008-05-22 00:00:00

abstract：:Genomic disorders are a group of human genetic diseases caused by genomic rearrangements resulting in copy-number variation (CNV) affecting a dosage-sensitive gene or genes critical for normal development or maintenance. These disorders represent a wide range of clinically distinct entities but include many diseases a...

journal_title：Neuron

authors： Lee JA,Lupski JR

更新日期：2006-10-05 00:00:00

abstract：:Inflammatory mediators act on peripheral sensory neurons to produce pain and hypersensitivity after tissue injury. In this issue of Neuron, Dina et al. report that inflammatory mediators, such as epinephrine and prostaglandins, appear to couple to specific G protein-coupled receptor signaling pathways through plastic ...

journal_title：Neuron

authors： Bhave G,Gereau RW 4th

更新日期：2003-08-14 00:00:00

abstract：:The entire length of myelinated axons is organized into a series of polarized domains that center around nodes of Ranvier. These domains, which are crucial for normal saltatory conduction, consist of distinct multiprotein complexes of cell adhesion molecules, ion channels, and scaffolding molecules; they also differ i...

journal_title：Neuron

authors： Salzer JL

更新日期：2003-10-09 00:00:00

abstract：:Interactions between the hippocampus and prefrontal cortex (PFC) are critical for learning and memory. Hippocampal activity during awake sharp-wave ripple (SWR) events is important for spatial learning, and hippocampal SWR activity often represents past or potential future experiences. Whether or how this reactivation...

journal_title：Neuron

authors： Jadhav SP,Rothschild G,Roumis DK,Frank LM

更新日期：2016-04-06 00:00:00

abstract：:Synaptic transmission is bioenergetically demanding, and the diverse processes underlying synaptic plasticity elevate these demands. Therefore, mitochondrial functions, including ATP synthesis and Ca2+ handling, are likely essential for plasticity. Although axonal mitochondria have been extensively analyzed, LTP is pr...

journal_title：Neuron

authors： Divakaruni SS,Van Dyke AM,Chandra R,LeGates TA,Contreras M,Dharmasri PA,Higgs HN,Lobo MK,Thompson SM,Blanpied TA

更新日期：2018-11-21 00:00:00

abstract：:The hippocampus is essential for spatiotemporal cognition. Sequences of neuronal activation provide a substrate for this fundamental function. At the behavioral timescale, these sequences have been shown to occur either in the presence of successive external landmarks or through internal mechanisms within an episodic ...

journal_title：Neuron

authors： Villette V,Malvache A,Tressard T,Dupuy N,Cossart R

更新日期：2015-10-21 00:00:00

abstract：:Protein kinase A (PKA) is a key regulator of neurosecretion, but the molecular targets remain elusive. We combined pharmacological manipulations of kinase and phosphatase activities with mutational studies on the exocytotic machinery driving fusion of catecholamine-containing vesicles from chromaffin cells. We found t...

journal_title：Neuron

authors： Nagy G,Reim K,Matti U,Brose N,Binz T,Rettig J,Neher E,Sørensen JB

更新日期：2004-02-05 00:00:00

abstract：:Kainate receptors signal through both ionotropic and metabotropic pathways. The high-affinity subunits, GluK4 and GluK5, are unique among the five receptor subunits, as they do not form homomeric receptors but modify the properties of heteromeric assemblies. Disruption of the Grik4 gene locus resulted in a significant...

journal_title：Neuron

authors： Fernandes HB,Catches JS,Petralia RS,Copits BA,Xu J,Russell TA,Swanson GT,Contractor A

更新日期：2009-09-24 00:00:00

abstract：:The blood-brain barrier (BBB) poses a major challenge for developing effective antibody therapies for neurological diseases. Using transcriptomic and proteomic profiling, we searched for proteins in mouse brain endothelial cells (BECs) that could potentially be exploited to transport antibodies across the BBB. Due to ...

journal_title：Neuron

authors： Zuchero YJ,Chen X,Bien-Ly N,Bumbaca D,Tong RK,Gao X,Zhang S,Hoyte K,Luk W,Huntley MA,Phu L,Tan C,Kallop D,Weimer RM,Lu Y,Kirkpatrick DS,Ernst JA,Chih B,Dennis MS,Watts RJ

更新日期：2016-01-06 00:00:00

abstract：:Properly functional CNS circuits depend on inhibitory interneurons that in turn rely upon activity-dependent gene expression for morphological development, connectivity, and excitatory-inhibitory coordination. Despite its importance, excitation-transcription coupling in inhibitory interneurons is poorly understood. We...

journal_title：Neuron

authors： Cohen SM,Ma H,Kuchibhotla KV,Watson BO,Buzsáki G,Froemke RC,Tsien RW

更新日期：2016-04-20 00:00:00

abstract：:The rhodopsin regulatory protein, visual arrestin, undergoes light-dependent trafficking in mammalian and Drosophila photoreceptor cells, though the mechanisms underlying these movements are poorly understood. In Drosophila, the movement of the visual arrestin, Arr2, functions in long-term adaptation and is dependent ...

journal_title：Neuron

authors： Lee SJ,Montell C

更新日期：2004-07-08 00:00:00

abstract：:To interpret visual-motion events, the underlying computation must involve internal reference to the motion status of the observer's head. We show here that layer 6 (L6) principal neurons in mouse primary visual cortex (V1) receive a diffuse, vestibular-mediated synaptic input that signals the angular velocity of hori...

journal_title：Neuron

authors： Vélez-Fort M,Bracey EF,Keshavarzi S,Rousseau CV,Cossell L,Lenzi SC,Strom M,Margrie TW

更新日期：2018-04-04 00:00:00

abstract：:Lattice-like structures known as perineuronal nets (PNNs) are key components of the extracellular matrix (ECM). Once fully crystallized by adulthood, they are largely stable throughout life. Contrary to previous reports that PNNs inhibit processes involving plasticity, here we report that the dynamic regulation of PNN...

journal_title：Neuron

authors： Banerjee SB,Gutzeit VA,Baman J,Aoued HS,Doshi NK,Liu RC,Ressler KJ

更新日期：2017-07-05 00:00:00

abstract：:Early postnatal mammals, including human babies, can perform only basic motor tasks. The acquisition of skilled behaviors occurs later, requiring anatomical changes in neural circuitry to support the development of coordinated activation or suppression of functionally related muscle groups. How this circuit reorganiza...

journal_title：Neuron

authors： Gu Z,Serradj N,Ueno M,Liang M,Li J,Baccei ML,Martin JH,Yoshida Y

更新日期：2017-05-03 00:00:00