Abstract：
:Elucidating the molecular mechanisms underlying quantitative neurocognitive phenotypes will further our understanding of the brain's structural and functional architecture and advance the diagnosis and treatment of the psychiatric disorders that these traits underlie. Although many neurocognitive traits are highly heritable, little progress has been made in identifying genetic variants unequivocally associated with these phenotypes. A major obstacle to such progress is the difficulty in identifying heritable neurocognitive measures that are precisely defined and systematically assessed and represent unambiguous mental constructs, yet are also amenable to the high-throughput phenotyping necessary to obtain adequate power for genetic association studies. In this perspective we compare the current status of genetic investigations of neurocognitive phenotypes to that of other categories of biomedically relevant traits and suggest strategies for genetically dissecting traits that may underlie disorders of brain and behavior.
journal_name
Neuronjournal_title
Neuronauthors
Congdon E,Poldrack RA,Freimer NBdoi
10.1016/j.neuron.2010.10.007subject
Has Abstractpub_date
2010-10-21 00:00:00pages
218-30issue
2eissn
0896-6273issn
1097-4199pii
S0896-6273(10)00831-7journal_volume
68pub_type
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