Rates and rhythms: a synergistic view of frequency and temporal coding in neuronal networks.

Abstract:

:In the CNS, activity of individual neurons has a small but quantifiable relationship to sensory representations and motor outputs. Coactivation of a few 10s to 100s of neurons can code sensory inputs and behavioral task performance within psychophysical limits. However, in a sea of sensory inputs and demand for complex motor outputs how is the activity of such small subpopulations of neurons organized? Two theories dominate in this respect: increases in spike rate (rate coding) and sharpening of the coincidence of spiking in active neurons (temporal coding). Both have computational advantages and are far from mutually exclusive. Here, we review evidence for a bias in neuronal circuits toward temporal coding and the coexistence of rate and temporal coding during population rhythm generation. The coincident expression of multiple types of gamma rhythm in sensory cortex suggests a mechanistic substrate for combining rate and temporal codes on the basis of stimulus strength.

journal_name

Neuron

journal_title

Neuron

authors

Ainsworth M,Lee S,Cunningham MO,Traub RD,Kopell NJ,Whittington MA

doi

10.1016/j.neuron.2012.08.004

subject

Has Abstract

pub_date

2012-08-23 00:00:00

pages

572-83

issue

4

eissn

0896-6273

issn

1097-4199

pii

S0896-6273(12)00709-X

journal_volume

75

pub_type

杂志文章,评审

相关文献

NEURON文献大全
  • Polarized domains of myelinated axons.

    abstract::The entire length of myelinated axons is organized into a series of polarized domains that center around nodes of Ranvier. These domains, which are crucial for normal saltatory conduction, consist of distinct multiprotein complexes of cell adhesion molecules, ion channels, and scaffolding molecules; they also differ i...

    journal_title:Neuron

    pub_type: 杂志文章,评审

    doi:10.1016/s0896-6273(03)00628-7

    authors: Salzer JL

    更新日期:2003-10-09 00:00:00

  • Olfaction: diverse species, conserved principles.

    abstract::Olfaction is a vitally important sense for all animals. There are striking similarities between species in the organization of the olfactory pathway, from the nature of the odorant receptor proteins, to perireceptor processes, to the organization of the olfactory CNS, through odor-guided behavior and memory. These com...

    journal_title:Neuron

    pub_type: 杂志文章,评审

    doi:10.1016/j.neuron.2005.10.022

    authors: Ache BW,Young JM

    更新日期:2005-11-03 00:00:00

  • Layer-specific targeting of direction-selective neurons in the zebrafish optic tectum.

    abstract::Direction selectivity (DS) is an important neuronal property in the visual system, but how DS is generated beyond the retina remains controversial. Here, we report a close correspondence between the preferred direction (PD) and the morphology of DS cells in the optic tectum. Ca(2+) imaging in cells expressing the gene...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/j.neuron.2012.12.003

    authors: Gabriel JP,Trivedi CA,Maurer CM,Ryu S,Bollmann JH

    更新日期:2012-12-20 00:00:00

  • Transient slow gamma synchrony underlies hippocampal memory replay.

    abstract::The replay of previously stored memories during hippocampal sharp wave ripples (SWRs) is thought to support both memory retrieval and consolidation in distributed hippocampal-neocortical circuits. Replay events consist of precisely timed sequences of spikes from CA3 and CA1 neurons that are coordinated both within and...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/j.neuron.2012.06.014

    authors: Carr MF,Karlsson MP,Frank LM

    更新日期:2012-08-23 00:00:00

  • Retinal axon pathfinding in the optic chiasm: divergence of crossed and uncrossed fibers.

    abstract::In the developing mammalian visual system, retinal fibers grow through the optic chiasm, where one population crosses to the opposite side of the brain and the other does not. Evidence from labeling growing retinal axons with the carbocyanine dye Dil in mouse embryos indicates that the two subpopulations diverge at a ...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/0896-6273(90)90307-2

    authors: Godement P,Salaün J,Mason CA

    更新日期:1990-08-01 00:00:00

  • Involvement of the ubiquitin-proteasome system in the early stages of wallerian degeneration.

    abstract::Local axon degeneration is a common pathological feature of many neurodegenerative diseases and peripheral neuropathies. While it is believed to operate with an apoptosis-independent molecular program, the underlying molecular mechanisms are largely unknown. In this study, we used the degeneration of transected axons,...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/s0896-6273(03)00429-x

    authors: Zhai Q,Wang J,Kim A,Liu Q,Watts R,Hoopfer E,Mitchison T,Luo L,He Z

    更新日期:2003-07-17 00:00:00

  • Regulation of synaptic vesicle recycling by calcium and serotonin.

    abstract::Serotonin, a neuromodulator at the crayfish neuromuscular junction, regulates neurotransmission without changing intracellular calcium levels. However, the mechanism of this regulation remains unclear. By analysis of synaptic depression using a depletion model and measurement of vesicle recycling using the styryl dye ...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/s0896-6273(00)80523-1

    authors: Wang C,Zucker RS

    更新日期:1998-07-01 00:00:00

  • Activating Injury-Responsive Genes with Hypoxia Enhances Axon Regeneration through Neuronal HIF-1α.

    abstract::Injured peripheral neurons successfully activate a proregenerative transcriptional program to enable axon regeneration and functional recovery. How transcriptional regulators coordinate the expression of such program remains unclear. Here we show that hypoxia-inducible factor 1α (HIF-1α) controls multiple injury-induc...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/j.neuron.2015.09.050

    authors: Cho Y,Shin JE,Ewan EE,Oh YM,Pita-Thomas W,Cavalli V

    更新日期:2015-11-18 00:00:00

  • Single-photon absorptions evoke synaptic depression in the retina to extend the operational range of rod vision.

    abstract::Adaptation or gain control allows sensory neurons to encode diverse stimuli using a limited range of output signals. Rod vision exemplifies a general challenge facing adaptational mechanisms-balancing the benefits of averaging to create a reliable signal for adaptation with the need to adapt rapidly and locally. The s...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/j.neuron.2008.01.031

    authors: Dunn FA,Rieke F

    更新日期:2008-03-27 00:00:00

  • Does neuronal synchrony underlie visual feature grouping?

    abstract::Previous research suggests that synchronous neural activity underlies perceptual grouping of visual image features. The generality of this mechanism is unclear, however, as previous studies have focused on pairs of neurons with overlapping or collinear receptive fields. By sampling more broadly and employing stimuli t...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/j.neuron.2005.03.002

    authors: Palanca BJ,DeAngelis GC

    更新日期:2005-04-21 00:00:00

  • Structure and assembly mechanism for heteromeric kainate receptors.

    abstract::Native glutamate receptor ion channels are tetrameric assemblies containing two or more different subunits. NMDA receptors are obligate heteromers formed by coassembly of two or three divergent gene families. While some AMPA and kainate receptors can form functional homomeric ion channels, the KA1 and KA2 subunits are...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/j.neuron.2011.05.038

    authors: Kumar J,Schuck P,Mayer ML

    更新日期:2011-07-28 00:00:00

  • Inhibition of high voltage-activated calcium currents by L-glutamate receptor-mediated calcium influx.

    abstract::The modulation of high voltage-activated (HVA) Ca2+ currents by L-glutamate and its agonists was investigated in cultured rat hypothalamic neurons. L-Glutamate and agonists selective for NMDA or non-NMDA receptors reversibly inhibited HVA Ca2+ currents. The putative presynaptic glutamate receptor agonist L-2-amino-4-p...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/0896-6273(93)90203-4

    authors: Zeilhofer HU,Müller TH,Swandulla D

    更新日期:1993-05-01 00:00:00

  • Spontaneous Synaptic Activation of Muscarinic Receptors by Striatal Cholinergic Neuron Firing.

    abstract::Cholinergic interneurons (CHIs) play a major role in motor and learning functions of the striatum. As acetylcholine does not directly evoke postsynaptic events at most striatal synapses, it remains unclear how postsynaptic cholinergic receptors encode the firing patterns of CHIs in the striatum. To examine the dynamic...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/j.neuron.2016.06.021

    authors: Mamaligas AA,Ford CP

    更新日期:2016-08-03 00:00:00

  • Patterns of fMRI activity dissociate overlapping functional brain areas that respond to biological motion.

    abstract::Accurate perception of the actions and intentions of other people is essential for successful interactions in a social environment. Several cortical areas that support this process respond selectively in fMRI to static and dynamic displays of human bodies and faces. Here we apply pattern-analysis techniques to arrive ...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/j.neuron.2006.02.004

    authors: Peelen MV,Wiggett AJ,Downing PE

    更新日期:2006-03-16 00:00:00

  • Drosophila SLC22A Transporter Is a Memory Suppressor Gene that Influences Cholinergic Neurotransmission to the Mushroom Bodies.

    abstract::The mechanisms that constrain memory formation are of special interest because they provide insights into the brain's memory management systems and potential avenues for correcting cognitive disorders. RNAi knockdown in the Drosophila mushroom body neurons (MBn) of a newly discovered memory suppressor gene, Solute Car...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/j.neuron.2016.03.017

    authors: Gai Y,Liu Z,Cervantes-Sandoval I,Davis RL

    更新日期:2016-05-04 00:00:00

  • Differential regulation of AMPA receptor subunit trafficking by palmitoylation of two distinct sites.

    abstract::Modification of AMPA receptor function is a major mechanism for the regulation of synaptic transmission and underlies several forms of synaptic plasticity. Post-translational palmitoylation is a reversible modification that regulates localization of many proteins. Here, we report that palmitoylation of the AMPA recept...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/j.neuron.2005.06.035

    authors: Hayashi T,Rumbaugh G,Huganir RL

    更新日期:2005-09-01 00:00:00

  • From Healthcare to Warfare and Reverse: How Should We Regulate Dual-Use Neurotechnology?

    abstract::Recent advances in military-funded neurotechnology and novel opportunities for misusing neurodevices show that the problem of dual use is inherent to neuroscience. This paper discusses how the neuroscience community should respond to these dilemmas and delineates a neuroscience-specific biosecurity framework. This neu...

    journal_title:Neuron

    pub_type: 杂志文章,评审

    doi:10.1016/j.neuron.2017.12.017

    authors: Ienca M,Jotterand F,Elger BS

    更新日期:2018-01-17 00:00:00

  • Gq alpha protein function in vivo: genetic dissection of its role in photoreceptor cell physiology.

    abstract::Heterotrimeric G proteins mediate a variety of signaling processes by coupling seven-transmembrane receptors to intracellular effector molecules. The Drosophila phototransduction cascade is a G protein-coupled signaling cascade that utilizes a phospholipase C (PLC beta) effector. PLC beta has been shown to be activate...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/0896-6273(95)90182-5

    authors: Scott K,Becker A,Sun Y,Hardy R,Zuker C

    更新日期:1995-10-01 00:00:00

  • Sensory deprivation unmasks a PKA-dependent synaptic plasticity mechanism that operates in parallel with CaMKII.

    abstract::Calcium/calmodulin kinase II (CaMKII) is required for LTP and experience-dependent potentiation in the barrel cortex. Here, we find that whisker deprivation increases LTP in the layer IV to II/III pathway and that PKA antagonists block the additional LTP. No LTP was seen in undeprived CaMKII-T286A mice, but whisker de...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/j.neuron.2008.10.018

    authors: Hardingham N,Wright N,Dachtler J,Fox K

    更新日期:2008-12-10 00:00:00

  • VRILLE feeds back to control circadian transcription of Clock in the Drosophila circadian oscillator.

    abstract::The Drosophila circadian oscillator consists of interlocked period (per)/timeless (tim) and Clock (Clk) transcriptional/translational feedback loops. Within these feedback loops, CLK and CYCLE (CYC) activate per and tim transcription at the same time as they repress Clk transcription, thus controlling the opposite cyc...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/s0896-6273(03)00002-3

    authors: Glossop NR,Houl JH,Zheng H,Ng FS,Dudek SM,Hardin PE

    更新日期:2003-01-23 00:00:00

  • Multiple Running Speed Signals in Medial Entorhinal Cortex.

    abstract::Grid cells in medial entorhinal cortex (MEC) can be modeled using oscillatory interference or attractor dynamic mechanisms that perform path integration, a computation requiring information about running direction and speed. The two classes of computational models often use either an oscillatory frequency or a firing ...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/j.neuron.2016.06.027

    authors: Hinman JR,Brandon MP,Climer JR,Chapman GW,Hasselmo ME

    更新日期:2016-08-03 00:00:00

  • Histone deacetylase 5 limits cocaine reward through cAMP-induced nuclear import.

    abstract::Chromatin remodeling by histone deacetylases (HDACs) is a key mechanism regulating behavioral adaptations to cocaine use. We report here that cocaine and cyclic adenosine monophosphate (cAMP) signaling induce the transient nuclear accumulation of HDAC5 in rodent striatum. We show that cAMP-stimulated nuclear import of...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/j.neuron.2011.10.032

    authors: Taniguchi M,Carreira MB,Smith LN,Zirlin BC,Neve RL,Cowan CW

    更新日期:2012-01-12 00:00:00

  • Asymmetric clathrin-mediated endocytosis drives repulsive growth cone guidance.

    abstract::Asymmetric Ca(2+) elevations across the axonal growth cone mediate its turning responses to attractive and repulsive guidance cues. Here we show that clathrin-mediated endocytosis acts downstream of Ca(2+) signals as driving machinery for growth cone turning. In dorsal root ganglion neurons, the formation of clathrin-...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/j.neuron.2010.04.007

    authors: Tojima T,Itofusa R,Kamiguchi H

    更新日期:2010-05-13 00:00:00

  • Hox genes: choreographers in neural development, architects of circuit organization.

    abstract::The neural circuits governing vital behaviors, such as respiration and locomotion, are comprised of discrete neuronal populations residing within the brainstem and spinal cord. Work over the past decade has provided a fairly comprehensive understanding of the developmental pathways that determine the identity of major...

    journal_title:Neuron

    pub_type: 杂志文章,评审

    doi:10.1016/j.neuron.2013.09.020

    authors: Philippidou P,Dasen JS

    更新日期:2013-10-02 00:00:00

  • Rod photoreceptor development in vitro: intrinsic properties of proliferating neuroepithelial cells change as development proceeds in the rat retina.

    abstract::We describe a reaggregated cell culture system in which retinal neuroepithelial cells from embryonic rats proliferate extensively and give rise to rod photoreceptors on the same schedule in vitro as they do in vivo. Both the proliferative potential of the embryonic neuroepithelial cells and the timing of their differe...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/0896-6273(90)90058-n

    authors: Watanabe T,Raff MC

    更新日期:1990-03-01 00:00:00

  • Glial cells maintain synaptic structure and function and promote development of the neuromuscular junction in vivo.

    abstract::To investigate the in vivo role of glial cells in synaptic function, maintenance, and development, we have developed an approach to selectively ablate perisynaptic Schwann cells (PSCs), the glial cells at the neuromuscular junction (NMJ), en masse from live frog muscles. In adults, following acute PSC ablation, synapt...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/s0896-6273(03)00682-2

    authors: Reddy LV,Koirala S,Sugiura Y,Herrera AA,Ko CP

    更新日期:2003-10-30 00:00:00

  • A Meta-Analysis Suggests Different Neural Correlates for Implicit and Explicit Learning.

    abstract::A meta-analysis of non-human primates performing three different tasks (Object-Match, Category-Match, and Category-Saccade associations) revealed signatures of explicit and implicit learning. Performance improved equally following correct and error trials in the Match (explicit) tasks, but it improved more after corre...

    journal_title:Neuron

    pub_type: 杂志文章,meta分析

    doi:10.1016/j.neuron.2017.09.032

    authors: Loonis RF,Brincat SL,Antzoulatos EG,Miller EK

    更新日期:2017-10-11 00:00:00

  • Curbing the excesses of youth: molecular insights into axonal pruning.

    abstract::The embryonic nervous system is refined over the course of development as a result of the twin processes of naturally occurring cell death and selective axon pruning. Recent studies provide new insights into the molecular events that underlie axon pruning and underscore the diversity of refinement processes employed b...

    journal_title:Neuron

    pub_type: 评论,杂志文章,评审

    doi:10.1016/s0896-6273(03)00364-7

    authors: Kantor DB,Kolodkin AL

    更新日期:2003-06-19 00:00:00

  • Rescuing Over-activated Microglia Restores Cognitive Performance in Juvenile Animals of the Dp(16) Mouse Model of Down Syndrome.

    abstract::Microglia are brain-resident immune cells and regulate mechanisms essential for cognitive functions. Down syndrome (DS), the most frequent cause of genetic intellectual disability, is caused by a supernumerary chromosome 21, containing also genes related to the immune system. In the hippocampus of the Dp(16) mouse mod...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/j.neuron.2020.09.010

    authors: Pinto B,Morelli G,Rastogi M,Savardi A,Fumagalli A,Petretto A,Bartolucci M,Varea E,Catelani T,Contestabile A,Perlini LE,Cancedda L

    更新日期:2020-12-09 00:00:00

  • The neural basis of perceptual learning.

    abstract::Perceptual learning is a lifelong process. We begin by encoding information about the basic structure of the natural world and continue to assimilate information about specific patterns with which we become familiar. The specificity of the learning suggests that all areas of the cerebral cortex are plastic and can rep...

    journal_title:Neuron

    pub_type: 杂志文章,评审

    doi:10.1016/s0896-6273(01)00424-x

    authors: Gilbert CD,Sigman M,Crist RE

    更新日期:2001-09-13 00:00:00