Abstract：
:The paraventricular nucleus of the thalamus (PVT) is thought to regulate behavioral responses under emotionally arousing conditions. Reward-associated cues activate PVT neurons; however, the specific PVT efferents regulating reward seeking remain elusive. Using a cued sucrose-seeking task, we manipulated PVT activity under two emotionally distinct conditions: (1) when reward was available during the cue as expected or (2) when reward was unexpectedly omitted during the cue. Pharmacological inactivation of the anterior PVT (aPVT), but not the posterior PVT, increased sucrose seeking only when reward was omitted. Consistent with this, photoactivation of aPVT neurons abolished sucrose seeking, and the firing of aPVT neurons differentiated reward availability. Photoinhibition of aPVT projections to the nucleus accumbens or to the amygdala increased or decreased, respectively, sucrose seeking only when reward was omitted. Our findings suggest that PVT bidirectionally modulates sucrose seeking under the negative (frustrative) conditions of reward omission.
journal_name
Neuronjournal_title
Neuronauthors
Do-Monte FH,Minier-Toribio A,Quiñones-Laracuente K,Medina-Colón EM,Quirk GJdoi
10.1016/j.neuron.2017.03.036subject
Has Abstractpub_date
2017-04-19 00:00:00pages
388-400.e4issue
2eissn
0896-6273issn
1097-4199pii
S0896-6273(17)30258-1journal_volume
94pub_type
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