Abstract：
:Innate defensive responses are essential for animal survival and are conserved across species. The ventral tegmental area (VTA) plays important roles in learned appetitive and aversive behaviors, but whether it plays a role in mediating or modulating innate defensive responses is currently unknown. We report that VTAGABA+ neurons respond to a looming stimulus. Inhibition of VTAGABA+ neurons reduced looming-evoked defensive flight behavior, and photoactivation of these neurons resulted in defense-like flight behavior. Using viral tracing and electrophysiological recordings, we show that VTAGABA+ neurons receive direct excitatory inputs from the superior colliculus (SC). Furthermore, we show that glutamatergic SC-VTA projections synapse onto VTAGABA+ neurons that project to the central nucleus of the amygdala (CeA) and that the CeA is involved in mediating the defensive behavior. Our findings demonstrate that aerial threat-related visual information is relayed to VTAGABA+ neurons mediating innate behavioral responses, suggesting a more general role of the VTA.
journal_name
Neuronjournal_title
Neuronauthors
Zhou Z,Liu X,Chen S,Zhang Z,Liu Y,Montardy Q,Tang Y,Wei P,Liu N,Li L,Song R,Lai J,He X,Chen C,Bi G,Feng G,Xu F,Wang Ldoi
10.1016/j.neuron.2019.05.027subject
Has Abstractpub_date
2019-08-07 00:00:00pages
473-488.e6issue
3eissn
0896-6273issn
1097-4199pii
S0896-6273(19)30480-5journal_volume
103pub_type
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