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Paradoxical Rules of Spike Train Decoding Revealed at the Sensitivity Limit of Vision.

Abstract：

:All sensory information is encoded in neural spike trains. It is unknown how the brain utilizes this neural code to drive behavior. Here, we unravel the decoding rules of the brain at the most elementary level by linking behavioral decisions to retinal output signals in a single-photon detection task. A transgenic mouse line allowed us to separate the two primary retinal outputs, ON and OFF pathways, carrying information about photon absorptions as increases and decreases in spiking, respectively. We measured the sensitivity limit of rods and the most sensitive ON and OFF ganglion cells and correlated these results with visually guided behavior using markerless head and eye tracking. We show that behavior relies only on the ON pathway even when the OFF pathway would allow higher sensitivity. Paradoxically, behavior does not rely on the spike code with maximal information but instead relies on a decoding strategy based on increases in spiking.

journal_name

Neuron

journal_title

Neuron

authors

Smeds L,Takeshita D,Turunen T,Tiihonen J,Westö J,Martyniuk N,Seppänen A,Ala-Laurila P

doi

10.1016/j.neuron.2019.08.005

subject

Has Abstract

pub_date

2019-11-06 00:00:00

pages

576-587.e11

issue

3

eissn

0896-6273

issn

1097-4199

pii

S0896-6273(19)30689-0

journal_volume

104

pub_type

杂志文章

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