Abstract:
:mRNAs for AMPA- and kainate-preferring glutamate receptor subunits are expressed abundantly in the CNS, yet functional studies of neurons and glia from brain suggest selective expression of AMPA receptors. We now show that glial cells of the O-2A lineage express rapidly desensitizing responses to kainate, mRNAs for GluR6, GluR7, KA-1, and KA-2, rapidly desensitizing responses to AMPA, and mRNAs for GluR-B, -C, and -D. Analysis of glutamate receptor currents in single cells reveals two receptor populations with high and low affinity for kainate and different sensitivity for potentiation by concanavalin A and for block of desensitization by cyclothiazide. Our experiments describe the characterization of native kainate-preferring receptors in glia and reveal coexpression in single cells of functional AMPA- and kainate-preferring receptors.
journal_name
Neuronjournal_title
Neuronauthors
Patneau DK,Wright PW,Winters C,Mayer ML,Gallo Vdoi
10.1016/0896-6273(94)90277-1subject
Has Abstractpub_date
1994-02-01 00:00:00pages
357-71issue
2eissn
0896-6273issn
1097-4199pii
0896-6273(94)90277-1journal_volume
12pub_type
杂志文章相关文献
NEURON文献大全abstract::Accumulation of specific proteins at synaptic structures is essential for synapse assembly and function, but mechanisms regulating local protein enrichment remain poorly understood. At the neuromuscular junction (NMJ), subsynaptic nuclei underlie motor axon terminals within extrafusal muscle fibers and are transcripti...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2007.07.028
更新日期:2007-09-06 00:00:00
abstract::Membrane potential recordings in awake mice have correlated cortical state with locomotion and whisker movements. In this issue of Neuron, Reimer et al. (2014) now reveal that pupil dilation in stationary mice equally signals a change in cortical state and an enhancement of visual processing. ...
journal_title:Neuron
pub_type: 评论,杂志文章
doi:10.1016/j.neuron.2014.10.005
更新日期:2014-10-22 00:00:00
abstract::Spike timing-dependent synaptic plasticity (STDP) serves as a key cellular correlate of associative learning, which is facilitated by elevated attentional and emotional states involving activation of adrenergic signaling. At cellular levels, adrenergic signaling increases dendrite excitability, but the underlying mech...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2016.12.039
更新日期:2017-01-18 00:00:00
abstract::The AMPA glutamate receptor (AMPAR) subunits GluR2 and GluR3 are thought to be important for synaptic targeting/stabilization of AMPARs and the expression of hippocampal long-term depression (LTD). In order to address this hypothesis genetically, we generated and analyzed knockout mice deficient in the expression of b...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(03)00368-4
更新日期:2003-07-03 00:00:00
abstract::Brandon et al. (2014) show that the formation of place cell representations in new environments is preserved under septal inactivation, and is thus likely independent of the hippocampal theta rhythm and, by implication, the firing of entorhinal grid cells and the process of path integration. ...
journal_title:Neuron
pub_type: 评论,杂志文章
doi:10.1016/j.neuron.2014.05.011
更新日期:2014-05-21 00:00:00
abstract::Neuroanatomical and functional asymmetries are universal features of the vertebrate CNS, but how asymmetry is generated is unknown. Here we show that zebrafish fgf8 mutants do not elaborate forebrain asymmetries, demonstrated by the failure of the parapineal nucleus to migrate from its initial midline position to the ...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2008.11.030
更新日期:2009-01-15 00:00:00
abstract::In this issue of Neuron,Lin et al. (2015) report an optical method to precisely manipulate the activity of GABAA receptors by designing a mutant receptor that binds photosensitive compounds. This allows for studying GABAA receptors in situ and represents a valuable tool to investigate how inhibition affects brain phys...
journal_title:Neuron
pub_type: 评论,杂志文章
doi:10.1016/j.neuron.2015.11.014
更新日期:2015-12-02 00:00:00
abstract::Advancing psychiatry requires understanding brain malfunction at a microscopic scale, where neurons and synapses operate under constraints imposed by behavior, cognition, and neural architecture. Nonhuman primates are unmatched in approximating the structural and computational environment of the human brain. ...
journal_title:Neuron
pub_type: 杂志文章,评审
doi:10.1016/j.neuron.2019.02.030
更新日期:2019-04-03 00:00:00
abstract::Brain function is mediated by neural circuit connectivity, and elucidating the role of connections is aided by techniques to block their output. We developed cell-type-selective, reversible synaptic inhibition tools for mammalian neural circuits by leveraging G protein signaling pathways to suppress synaptic vesicle r...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2014.04.008
更新日期:2014-05-21 00:00:00
abstract::S-Nitrosylation is a redox-mediated posttranslational modification that regulates protein function via covalent reaction of nitric oxide (NO)-related species with a cysteine thiol group on the target protein. Under physiological conditions, S-nitrosylation can be an important modulator of signal transduction pathways,...
journal_title:Neuron
pub_type: 杂志文章,评审
doi:10.1016/j.neuron.2013.05.005
更新日期:2013-05-22 00:00:00
abstract::EPAC proteins are the guanine nucleotide exchange factors that act as the intracellular receptors for cyclic AMP. Two variants of EPAC genes including EPAC1 and EPAC2 are cloned and are widely expressed throughout the brain. But, their functions in the brain remain unknown. Here, we genetically delete EPAC1 (EPAC1(-/-...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2012.02.003
更新日期:2012-02-23 00:00:00
abstract::Commissural axons are attracted to the midline intermediate target by chemoattractants, but upon crossing the midline they switch off responsiveness to attractants and switch on responsiveness to midline repellents, which expel the axons from the midline and enable them to move on. Here we show that midline exit also ...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2008.01.006
更新日期:2008-02-28 00:00:00
abstract::The field of motor pattern generation and motor control has progressed markedly in the last decade. There has been a revolutionary shift in thinking from hard-wired circuits to multifunctional networks. Yet, it is clear that we still have a long way to go before we understand how very large ensembles of neurons produc...
journal_title:Neuron
pub_type: 杂志文章,评审
doi:10.1016/s0896-6273(00)80043-4
更新日期:1996-02-01 00:00:00
abstract::In rodents, each main olfactory bulb contains two mirror-symmetric glomerular maps, a feature not found in the initial topographic maps of other sensory systems. Targeting tracer injections to identified glomeruli revealed that isofunctional odor columns-translaminar assemblies connected to a given glomerulus-were spe...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(03)00194-6
更新日期:2003-04-24 00:00:00
abstract::The auditory cortex encodes information about sounds through the combined activity of large numbers of neurons, but the way this population activity is organized has not been clear. In this issue of Neuron, Bathellier et al. (2012) show that firing in the superficial layers of auditory cortex is organized into a small...
journal_title:Neuron
pub_type: 评论,杂志文章
doi:10.1016/j.neuron.2012.10.007
更新日期:2012-10-18 00:00:00
abstract::We have combined functional maps of retinotopy (eccentricity and meridian mapping), object category, and motion in a group of subjects to explore the large-scale topography of higher-order object areas. Our results reveal seven consistent category-related entities situated in the occipito-temporal cortex adjoining ear...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(03)00144-2
更新日期:2003-03-27 00:00:00
abstract::Sensory input reaching the brain from bilateral and offset channels is nonetheless perceived as unified. This unity could be explained by simultaneous projections to both hemispheres, or inter-hemispheric information transfer between sensory cortical maps. Odor input, however, is not topographically organized, nor doe...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2018.07.012
更新日期:2018-08-22 00:00:00
abstract::New technologies to probe the nervous system are propelling innovation and discovery at blinding speed, but are our trainees prepared to maximize this power? The growing role of engineering in research, such as materials, computing, electronics, and devices, compels us to rethink neuroscience education. Core technolog...
journal_title:Neuron
pub_type: 杂志文章,评审
doi:10.1016/j.neuron.2015.03.029
更新日期:2015-04-08 00:00:00
abstract::To advance the understanding of sleep regulation, we screened for sleep-promoting cells and identified neurons expressing neuropeptide Y-like short neuropeptide F (sNPF). Sleep induction by sNPF meets all relevant criteria. Rebound sleep following sleep deprivation is reduced by activation of sNPF neurons, and flies e...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2013.07.029
更新日期:2013-10-02 00:00:00
abstract::Evolutionary conservation of members of the NGF family in vertebrates was studied by DNA sequence analysis of PCR fragments for NGF, BDNF, and NT-3 from human, rat, chicken, viper, Xenopus, salmon, and ray. The results showed that the three factors are highly conserved from fishes to mammals. Phylogenetic trees reflec...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(91)90180-8
更新日期:1991-05-01 00:00:00
abstract::At least 30 types of retinal ganglion cells (RGCs) send distinct messages through the optic nerve to the brain. Available strategies of promoting axon regeneration act on only some of these types. Here we tested the hypothesis that overexpressing developmentally important transcription factors in adult RGCs could repr...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2017.05.035
更新日期:2017-06-21 00:00:00
abstract::In the precedence effect, sounds emanating directly from the source are localized preferentially over their reflections. Although most studies have focused on the delay between the onset of a sound and its echo, humans still experience the precedence effect when this onset delay is removed. We tested in barn owls the ...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2010.07.014
更新日期:2010-08-26 00:00:00
abstract::We sought to obtain novel insights into schizophrenia pathogenesis by exploiting the association between the disorder and chromosomal copy number (CNV) burden. We combined data from 5,745 cases and 10,675 controls with other published datasets containing genome-wide CNV data. In this much-enlarged sample of 11,355 cas...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2015.04.022
更新日期:2015-06-03 00:00:00
abstract::Unequivocal proof that the activity of a localized cortical neuronal population provides sufficient basis for a specific cognitive function has rarely been obtained. We looked for such proof in monkeys trained to discriminate between two mechanical flutter stimuli applied sequentially to the fingertips. Microelectrode...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(00)81156-3
更新日期:2000-04-01 00:00:00
abstract::Primates can learn to recognize a virtually limitless number of visual objects. A candidate neural substrate for this adult plasticity is the inferior temporal cortex (ITC). Using a large stimulus set, we explored the impact that long-term experience has on the response properties of two classes of neurons in ITC: bro...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2012.01.032
更新日期:2012-04-12 00:00:00
abstract::We measured brain activity during mental rotation and object recognition with objects rotated around three different axes. Activity in the superior parietal lobe (SPL) increased proportionally to viewpoint disparity during mental rotation, but not during object recognition. In contrast, the fusiform gyrus was preferen...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(02)00622-0
更新日期:2002-03-28 00:00:00
abstract::Voltage-gated ion channels generate electrical signals in species from bacteria to man. Their voltage-sensing modules are responsible for initiation of action potentials and graded membrane potential changes in response to synaptic input and other physiological stimuli. Extensive structure-function studies, structure ...
journal_title:Neuron
pub_type: 杂志文章,评审
doi:10.1016/j.neuron.2010.08.021
更新日期:2010-09-23 00:00:00
abstract::To study the effect of cell type-restricted hamster PrP expression on susceptibility to the hamster scrapie agent, we generated transgenic mice using a 1 kb hamster cDNA clone containing the 0.76 kb HPrP open reading frame under control of the neuron-specific enolase promoter. In these mice, expression of HPrP was det...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(95)90105-1
更新日期:1995-11-01 00:00:00
abstract::MicroRNAs (miRNAs) are noncoding RNAs that suppress translation of specific mRNAs. The miRNA machinery interacts with fragile X mental retardation protein (FMRP), which functions as translational repressor. We show that miR-125b and miR-132, as well as several other miRNAs, are associated with FMRP in mouse brain. miR...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2010.01.005
更新日期:2010-02-11 00:00:00
abstract::To achieve simultaneous measurement of multiple cellular events in molecularly defined groups of neurons in vivo, we designed a spectrometer-based fiber photometry system that allows for spectral unmixing of multiple fluorescence signals recorded from deep brain structures in behaving animals. Using green and red Ca2+...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2018.04.012
更新日期:2018-05-16 00:00:00