Glial cells of the oligodendrocyte lineage express both kainate- and AMPA-preferring subtypes of glutamate receptor.

Abstract:

:mRNAs for AMPA- and kainate-preferring glutamate receptor subunits are expressed abundantly in the CNS, yet functional studies of neurons and glia from brain suggest selective expression of AMPA receptors. We now show that glial cells of the O-2A lineage express rapidly desensitizing responses to kainate, mRNAs for GluR6, GluR7, KA-1, and KA-2, rapidly desensitizing responses to AMPA, and mRNAs for GluR-B, -C, and -D. Analysis of glutamate receptor currents in single cells reveals two receptor populations with high and low affinity for kainate and different sensitivity for potentiation by concanavalin A and for block of desensitization by cyclothiazide. Our experiments describe the characterization of native kainate-preferring receptors in glia and reveal coexpression in single cells of functional AMPA- and kainate-preferring receptors.

journal_name

Neuron

journal_title

Neuron

authors

Patneau DK,Wright PW,Winters C,Mayer ML,Gallo V

doi

10.1016/0896-6273(94)90277-1

subject

Has Abstract

pub_date

1994-02-01 00:00:00

pages

357-71

issue

2

eissn

0896-6273

issn

1097-4199

pii

0896-6273(94)90277-1

journal_volume

12

pub_type

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