V3 spinal neurons establish a robust and balanced locomotor rhythm during walking.

Abstract:

:A robust and well-organized rhythm is a key feature of many neuronal networks, including those that regulate essential behaviors such as circadian rhythmogenesis, breathing, and locomotion. Here we show that excitatory V3-derived neurons are necessary for a robust and organized locomotor rhythm during walking. When V3-mediated neurotransmission is selectively blocked by the expression of the tetanus toxin light chain subunit (TeNT), the regularity and robustness of the locomotor rhythm is severely perturbed. A similar degeneration in the locomotor rhythm occurs when the excitability of V3-derived neurons is reduced acutely by ligand-induced activation of the allatostatin receptor. The V3-derived neurons additionally function to balance the locomotor output between both halves of the spinal cord, thereby ensuring a symmetrical pattern of locomotor activity during walking. We propose that the V3 neurons establish a regular and balanced motor rhythm by distributing excitatory drive between both halves of the spinal cord.

journal_name

Neuron

journal_title

Neuron

authors

Zhang Y,Narayan S,Geiman E,Lanuza GM,Velasquez T,Shanks B,Akay T,Dyck J,Pearson K,Gosgnach S,Fan CM,Goulding M

doi

10.1016/j.neuron.2008.09.027

subject

Has Abstract

pub_date

2008-10-09 00:00:00

pages

84-96

issue

1

eissn

0896-6273

issn

1097-4199

pii

S0896-6273(08)00806-4

journal_volume

60

pub_type

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