当前位置： SCI文献检索 > NEURON期刊下所有文献 > Cortical maps and white matter tracts following long period of visual deprivation and retinal image restoration.

Cortical maps and white matter tracts following long period of visual deprivation and retinal image restoration.

Abstract：

:Abnormal visual input during development has dramatic effects on the visual system. How does the adult visual system respond when input is corrected? MM lost his left eye and became blind in the right due to corneal damage at the age of 3. At age 46, MM regained his retinal image, but his visual abilities, even seven years following the surgery, remain severely limited, and he does not rely on vision for daily life. Neuroimaging measurements reveal several differences among MM, sighted controls, sighted monocular, and early blind subjects. We speculate that these differences stem from damage during the critical period in development of retinal neurons with small, foveal receptive fields. In this case, restoration of functional vision requires more than improving retinal image contrast. In general, visual restoration will require accounting for the developmental trajectory of the individual and the consequences of the early deprivation on cortical circuitry.

journal_name

Neuron

journal_title

Neuron

authors

Levin N,Dumoulin SO,Winawer J,Dougherty RF,Wandell BA

doi

10.1016/j.neuron.2009.12.006

subject

Has Abstract

pub_date

2010-01-14 00:00:00

pages

21-31

issue

1

eissn

0896-6273

issn

1097-4199

pii

S0896-6273(09)00996-9

journal_volume

65

pub_type

杂志文章

相关文献

NEURON文献大全
  • Regulation of AMPA receptor function by the human memory-associated gene KIBRA.

    abstract：:KIBRA has recently been identified as a gene associated with human memory performance. Despite the elucidation of the role of KIBRA in several diverse processes in nonneuronal cells, the molecular function of KIBRA in neurons is unknown. We found that KIBRA directly binds to the protein interacting with C-kinase 1 (PI...

    journal_title：Neuron

    pub_type： 杂志文章

    doi：10.1016/j.neuron.2011.08.017

    authors： Makuch L,Volk L,Anggono V,Johnson RC,Yu Y,Duning K,Kremerskothen J,Xia J,Takamiya K,Huganir RL

    更新日期：2011-09-22 00:00:00

  • The mysterious motivational functions of mesolimbic dopamine.

    abstract：:Nucleus accumbens dopamine is known to play a role in motivational processes, and dysfunctions of mesolimbic dopamine may contribute to motivational symptoms of depression and other disorders, as well as features of substance abuse. Although it has become traditional to label dopamine neurons as "reward" neurons, this...

    journal_title：Neuron

    pub_type： 杂志文章,评审

    doi：10.1016/j.neuron.2012.10.021

    authors： Salamone JD,Correa M

    更新日期：2012-11-08 00:00:00

  • Motor Learning Consolidates Arc-Expressing Neuronal Ensembles in Secondary Motor Cortex.

    abstract：:Motor behaviors recruit task-specific neuronal ensembles in motor cortices, which are consolidated over subsequent learning. However, little is known about the molecules that can identify the participating neurons and predict the outcomes of the consolidation process. Using a mouse rotarod-learning task, we showed tha...

    journal_title：Neuron

    pub_type： 杂志文章

    doi：10.1016/j.neuron.2015.05.022

    authors： Cao VY,Ye Y,Mastwal S,Ren M,Coon M,Liu Q,Costa RM,Wang KH

    更新日期：2015-06-17 00:00:00

  • Undercover Power of Endocannabinoids: Postsynaptic Ion-Channel Modulator.

    abstract：:In this issue of Neuron, Gantz and Bean (2017) show that the endocannabinoid 2-arachidonoyl glycerol (2-AG) can directly alter the properties of native ion-channel Kv4.3 and accelerate the pacemaker activity of rodent dopamine neurons. These findings are one of the first demonstrations of postsynaptic, cell-autonomous...

    journal_title：Neuron

    pub_type： 杂志文章

    doi：10.1016/j.neuron.2017.03.014

    authors： Matsui A,Alvarez VA

    更新日期：2017-03-22 00:00:00

  • A lethal convergence of dopamine and calcium.

    abstract：:The controversy about whether dopamine contributes to cell loss in Parkinson's disease takes a new turn as Mosharov et al. in this issue of Neuron demonstrate that Ca2+ influx through L-type channels elevates dopamine synthesis to potentially toxic levels in vulnerable ventral mesencephalon neurons. ...

    journal_title：Neuron

    pub_type： 评论,杂志文章

    doi：10.1016/j.neuron.2009.04.010

    authors： Surmeier DJ

    更新日期：2009-04-30 00:00:00

  • Coordinated Excitation and Inhibition of Prefrontal Ensembles during Awake Hippocampal Sharp-Wave Ripple Events.

    abstract：:Interactions between the hippocampus and prefrontal cortex (PFC) are critical for learning and memory. Hippocampal activity during awake sharp-wave ripple (SWR) events is important for spatial learning, and hippocampal SWR activity often represents past or potential future experiences. Whether or how this reactivation...

    journal_title：Neuron

    pub_type： 杂志文章

    doi：10.1016/j.neuron.2016.02.010

    authors： Jadhav SP,Rothschild G,Roumis DK,Frank LM

    更新日期：2016-04-06 00:00:00

  • Inhibitory Basal Ganglia Inputs Induce Excitatory Motor Signals in the Thalamus.

    abstract：:Basal ganglia (BG) circuits orchestrate complex motor behaviors predominantly via inhibitory synaptic outputs. Although these inhibitory BG outputs are known to reduce the excitability of postsynaptic target neurons, precisely how this change impairs motor performance remains poorly understood. Here, we show that opto...

    journal_title：Neuron

    pub_type： 杂志文章

    doi：10.1016/j.neuron.2017.08.028

    authors： Kim J,Kim Y,Nakajima R,Shin A,Jeong M,Park AH,Jeong Y,Jo S,Yang S,Park H,Cho SH,Cho KH,Shim I,Chung JH,Paik SB,Augustine GJ,Kim D

    更新日期：2017-08-30 00:00:00

  • Kinetics of a human glutamate transporter.

    abstract：:Currents mediated by a glutamate transporter cloned from human motor cortex were measured in Xenopus oocytes. In the absence of glutamate, voltage jumps induced Na(+)-dependent capacitive currents that were blocked by kainate, a competitive transport antagonist. The pre-steady-state currents can be described by an ord...

    journal_title：Neuron

    pub_type： 杂志文章

    doi：10.1016/0896-6273(95)90340-2

    authors： Wadiche JI,Arriza JL,Amara SG,Kavanaugh MP

    更新日期：1995-05-01 00:00:00

  • Basolateral amygdala neurons facilitate reward-seeking behavior by exciting nucleus accumbens neurons.

    abstract：:Both the nucleus accumbens (NAc) and basolateral amygdala (BLA) contribute to learned behavioral choice. Neurons in both structures that encode reward-predictive cues may underlie the decision to respond to such cues, but the neural circuits by which the BLA influences reward-seeking behavior have not been established...

    journal_title：Neuron

    pub_type： 杂志文章

    doi：10.1016/j.neuron.2008.07.004

    authors： Ambroggi F,Ishikawa A,Fields HL,Nicola SM

    更新日期：2008-08-28 00:00:00

  • An arousing discovery on catalepsy: orexin regulates vestibular motor functions.

    abstract：:A study by Zhang et al. in this issue of Neuron reveals a novel mechanism of control of vestibular motor functions by the orexin (hypocretin) system in the perifornical/LH area through the lateral vestibular nucleus in the brainstem. This knowledge provides new insights into the understanding of brain circuitry that c...

    journal_title：Neuron

    pub_type： 评论,杂志文章

    doi：10.1016/j.neuron.2011.02.017

    authors： Gao XB,Horvath TL

    更新日期：2011-02-24 00:00:00

  • How early is firing required for wiring?

    abstract：:Activity is known to be important for the refinement of neural connections in the developing brain. In this issue of Neuron, Hanson and Landmesser provide evidence that GABA-dependent spontaneous bursting of motor neurons in the embryonic spinal cord is required for the correct execution of an early axon pathfinding d...

    journal_title：Neuron

    pub_type： 评论,杂志文章,评审

    doi：10.1016/j.neuron.2004.08.027

    authors： Goulding M

    更新日期：2004-09-02 00:00:00

  • Great Expectations: Anticipatory Control of Magnocellular Vasopressin Neurons.

    abstract：:Real-time activity measurements of genetically identified neuroendocrine vasopressin neurons show they can anticipate osmotic challenges. In this issue of Neuron, Mandelblat-Cerf et al. (2017) show that correlating these results with ongoing behavior and plasma osmolality points to the existence of brain networks that...

    journal_title：Neuron

    pub_type： 杂志文章

    doi：10.1016/j.neuron.2016.12.033

    authors： Watts AG

    更新日期：2017-01-04 00:00:00

  • NPAS1 represses the generation of specific subtypes of cortical interneurons.

    abstract：:Little is known about genetic mechanisms that regulate the ratio of cortical excitatory and inhibitory neurons. We show that NPAS1 and NPAS3 transcription factors (TFs) are expressed in progenitor domains of the mouse basal ganglia (subpallium, MGE, and CGE). NPAS1(-/-) mutants had increased proliferation, ERK signali...

    journal_title：Neuron

    pub_type： 杂志文章

    doi：10.1016/j.neuron.2014.10.040

    authors： Stanco A,Pla R,Vogt D,Chen Y,Mandal S,Walker J,Hunt RF,Lindtner S,Erdman CA,Pieper AA,Hamilton SP,Xu D,Baraban SC,Rubenstein JL

    更新日期：2014-12-03 00:00:00

  • Is top-down control from prefrontal cortex necessary for visual categorization?

    abstract：:The brain mechanisms underlying visual object categorization remain unclear. In this issue of Neuron, Minamimoto and colleagues introduce a novel task that associates each category with a different incentive value, and they demonstrate that it can be learned within a single session even after ablation of the lateral p...

    journal_title：Neuron

    pub_type： 评论,杂志文章

    doi：10.1016/j.neuron.2010.05.012

    authors： Buckley MJ,Sigala N

    更新日期：2010-05-27 00:00:00

  • Myosin II is involved in transmitter release at synapses formed between rat sympathetic neurons in culture.

    abstract：:The presynaptic function of myosin II was studied at cholinergic synapses formed between rat superior cervical ganglion neurons in culture. Immunofluorescent staining showed that myosin II was colocalized with synaptophysin at the presynaptic nerve terminals. Antimyosin II antibody introduced into presynaptic neurons ...

    journal_title：Neuron

    pub_type： 杂志文章

    doi：10.1016/0896-6273(94)90051-5

    authors： Mochida S,Kobayashi H,Matsuda Y,Yuda Y,Muramoto K,Nonomura Y

    更新日期：1994-11-01 00:00:00

  • A key role of starburst amacrine cells in originating retinal directional selectivity and optokinetic eye movement.

    abstract：:The directional selectivity of retinal ganglion cell responses represents a primitive pattern recognition that operates within a retinal neural circuit. The cellular origin and mechanism of directional selectivity were investigated by selectively eliminating retinal starburst amacrine cells, using immunotoxin-mediated...

    journal_title：Neuron

    pub_type： 杂志文章

    doi：10.1016/s0896-6273(01)00316-6

    authors： Yoshida K,Watanabe D,Ishikane H,Tachibana M,Pastan I,Nakanishi S

    更新日期：2001-06-01 00:00:00

  • The representation of time for motor learning.

    abstract：:We have identified factors that control precise motor timing by studying learning in smooth pursuit eye movements. Monkeys tracked a target that moved horizontally for a fixed time interval before changing direction through the addition of a vertical component of motion. After repeated presentations of the same target...

    journal_title：Neuron

    pub_type： 杂志文章

    doi：10.1016/j.neuron.2004.12.017

    authors： Medina JF,Carey MR,Lisberger SG

    更新日期：2005-01-06 00:00:00

  • Seeing Is Believing: Myelin Dynamics in the Adult CNS.

    abstract：:Live imaging studies in mice show that adult-born oligodendrocytes and myelin are remarkably stable. Neural activity enhances oligodendrocyte integration, arguing that internode addition rather than alteration represents the mechanism for any experience-dependent cortical myelination changes that might underpin learni...

    journal_title：Neuron

    pub_type： 杂志文章,评审

    doi：10.1016/j.neuron.2018.05.005

    authors： Swire M,Ffrench-Constant C

    更新日期：2018-05-16 00:00:00

  • Dynamic encoding of perception, memory, and movement in a C. elegans chemotaxis circuit.

    abstract：:Brain circuits endow behavioral flexibility. Here, we study circuits encoding flexible chemotaxis in C. elegans, where the animal navigates up or down NaCl gradients (positive or negative chemotaxis) to reach the salt concentration of previous growth (the set point). The ASER sensory neuron mediates positive and negat...

    journal_title：Neuron

    pub_type： 杂志文章

    doi：10.1016/j.neuron.2014.05.010

    authors： Luo L,Wen Q,Ren J,Hendricks M,Gershow M,Qin Y,Greenwood J,Soucy ER,Klein M,Smith-Parker HK,Calvo AC,Colón-Ramos DA,Samuel AD,Zhang Y

    更新日期：2014-06-04 00:00:00

  • LTP inhibits LTD in the hippocampus via regulation of GSK3beta.

    abstract：:Glycogen synthase kinase-3 (GSK3) has been implicated in major neurological disorders, but its role in normal neuronal function is largely unknown. Here we show that GSK3beta mediates an interaction between two major forms of synaptic plasticity in the brain, N-methyl-D-aspartate (NMDA) receptor-dependent long-term po...

    journal_title：Neuron

    pub_type： 杂志文章

    doi：10.1016/j.neuron.2007.01.029

    authors： Peineau S,Taghibiglou C,Bradley C,Wong TP,Liu L,Lu J,Lo E,Wu D,Saule E,Bouschet T,Matthews P,Isaac JT,Bortolotto ZA,Wang YT,Collingridge GL

    更新日期：2007-03-01 00:00:00

  • Knot/Collier and cut control different aspects of dendrite cytoskeleton and synergize to define final arbor shape.

    abstract：:In a complex nervous system, neuronal functional diversity is reflected in the wide variety of dendritic arbor shapes. Different neuronal classes are defined by class-specific transcription factor combinatorial codes. We show that the combination of the transcription factors Knot and Cut is particular to Drosophila cl...

    journal_title：Neuron

    pub_type： 杂志文章

    doi：10.1016/j.neuron.2007.10.031

    authors： Jinushi-Nakao S,Arvind R,Amikura R,Kinameri E,Liu AW,Moore AW

    更新日期：2007-12-20 00:00:00

  • Discrete Stepping and Nonlinear Ramping Dynamics Underlie Spiking Responses of LIP Neurons during Decision-Making.

    abstract：:Neurons in LIP exhibit ramping trial-averaged responses during decision-making. Recent work sparked debate over whether single-trial LIP spike trains are better described by discrete "stepping" or continuous "ramping" dynamics. We extended latent dynamical spike train models and used Bayesian model comparison to addre...

    journal_title：Neuron

    pub_type： 杂志文章

    doi：10.1016/j.neuron.2019.04.031

    authors： Zoltowski DM,Latimer KW,Yates JL,Huk AC,Pillow JW

    更新日期：2019-06-19 00:00:00

  • A Mirror-Symmetric Excitatory Link Coordinates Odor Maps across Olfactory Bulbs and Enables Odor Perceptual Unity.

    abstract：:Sensory input reaching the brain from bilateral and offset channels is nonetheless perceived as unified. This unity could be explained by simultaneous projections to both hemispheres, or inter-hemispheric information transfer between sensory cortical maps. Odor input, however, is not topographically organized, nor doe...

    journal_title：Neuron

    pub_type： 杂志文章

    doi：10.1016/j.neuron.2018.07.012

    authors： Grobman M,Dalal T,Lavian H,Shmuel R,Belelovsky K,Xu F,Korngreen A,Haddad R

    更新日期：2018-08-22 00:00:00

  • The balance between capture and dissociation of presynaptic proteins controls the spatial distribution of synapses.

    abstract：:The location, size, and number of synapses critically influence the specificity and strength of neural connections. In axons, synaptic vesicle (SV) and active zone (AZ) proteins are transported by molecular motors and accumulate at discrete presynaptic loci. Little is known about the mechanisms coordinating presynapti...

    journal_title：Neuron

    pub_type： 杂志文章

    doi：10.1016/j.neuron.2013.04.035

    authors： Wu YE,Huo L,Maeder CI,Feng W,Shen K

    更新日期：2013-06-19 00:00:00

  • Synaptic homeostasis on the fast track.

    abstract：:Synaptic homeostasis is a phenomenon that prevents the nervous system from descending into chaos. In this issue of Neuron, Frank et al. overturn the notion that synaptic homeostasis at Drosophila NMJs is a slow developmental process. They report that postsynaptic changes are offset within minutes by a homeostatic incr...

    journal_title：Neuron

    pub_type： 评论,杂志文章,评审

    doi：10.1016/j.neuron.2006.11.006

    authors： Macleod GT,Zinsmaier KE

    更新日期：2006-11-22 00:00:00

  • Insulin-like growth factor I increases brain growth and central nervous system myelination in transgenic mice.

    abstract：:Insulin-like growth factor I (IGF-I) is a potent regulator of oligodendrocyte development and myelination in vitro, but its effect on myelination in vivo has never been tested directly. Therefore, we examined brain growth and myelination in a transgenic mouse line that overexpresses IGF-I. By postnatal day 55, when br...

    journal_title：Neuron

    pub_type： 杂志文章

    doi：10.1016/0896-6273(93)90173-o

    authors： Carson MJ,Behringer RR,Brinster RL,McMorris FA

    更新日期：1993-04-01 00:00:00

  • From Healthcare to Warfare and Reverse: How Should We Regulate Dual-Use Neurotechnology?

    abstract：:Recent advances in military-funded neurotechnology and novel opportunities for misusing neurodevices show that the problem of dual use is inherent to neuroscience. This paper discusses how the neuroscience community should respond to these dilemmas and delineates a neuroscience-specific biosecurity framework. This neu...

    journal_title：Neuron

    pub_type： 杂志文章,评审

    doi：10.1016/j.neuron.2017.12.017

    authors： Ienca M,Jotterand F,Elger BS

    更新日期：2018-01-17 00:00:00

  • Biallelic Mutations in MYORG Cause Autosomal Recessive Primary Familial Brain Calcification.

    abstract：:Primary familial brain calcification (PFBC) is a genetically heterogeneous disorder characterized by bilateral calcifications in the basal ganglia and other brain regions. The genetic basis of this disorder remains unknown in a significant portion of familial cases. Here, we reported a recessive causal gene, MYORG, fo...

    journal_title：Neuron

    pub_type： 杂志文章

    doi：10.1016/j.neuron.2018.05.037

    authors： Yao XP,Cheng X,Wang C,Zhao M,Guo XX,Su HZ,Lai LL,Zou XH,Chen XJ,Zhao Y,Dong EL,Lu YQ,Wu S,Li X,Fan G,Yu H,Xu J,Wang N,Xiong ZQ,Chen WJ

    更新日期：2018-06-27 00:00:00

  • Expression of beta amyloid protein precursor mRNAs: recognition of a novel alternatively spliced form and quantitation in Alzheimer's disease using PCR.

    abstract：:We have analyzed alternatively spliced beta amyloid protein precursor (beta APP) mRNAs by using the polymerase chain reaction to amplify beta APP cDNAs produced by reverse transcription. With this approach the three previously characterized beta APP mRNAs (beta APP695, beta APP751, and beta APP770) are readily detecte...

    journal_title：Neuron

    pub_type： 杂志文章

    doi：10.1016/0896-6273(90)90100-t

    authors： Golde TE,Estus S,Usiak M,Younkin LH,Younkin SG

    更新日期：1990-02-01 00:00:00

  • Pathfinding and synapse formation in a zebrafish mutant lacking functional acetylcholine receptors.

    abstract：:We induced and characterized a recessive lethal mutation, nic-1, in zebrafish that blocks the function of muscle acetylcholine (ACh) receptors. Homozygous nic-1 embryos are nonmotile and fail to respond to exogenous application of cholinergic agonists, although their muscles contract in response to direct electrical s...

    journal_title：Neuron

    pub_type： 杂志文章

    doi：10.1016/0896-6273(90)90139-7

    authors： Westerfield M,Liu DW,Kimmel CB,Walker C

    更新日期：1990-06-01 00:00:00