Abstract:
:The retinal pigment epithelium (RPE) plays an essential role in the normal development of the underlying neural retina, but the mechanisms by which this regulation occurs are largely unknown. Ca2+ transients, induced by the neurotransmitter ATP acting on purinergic receptors, both increase proliferation and stimulate DNA synthesis in neural retinal progenitor cells. Here, we show that the RPE regulates proliferation in the underlying neural retina by the release of a soluble factor and identify that factor as ATP. Further, we show that this ATP is released by efflux through gap junction connexin 43 hemichannels, the opening of which is evoked by spontaneous elevations of Ca2+ in trigger cells in the RPE. This release mechanism is localized within the RPE cells to the membranes facing the neural retina, a location ideally positioned to influence neural retinal development. ATP released from RPE hemichannels speeds both cell division and proliferation in the neural retina.
journal_name
Neuronjournal_title
Neuronauthors
Pearson RA,Dale N,Llaudet E,Mobbs Pdoi
10.1016/j.neuron.2005.04.024subject
Has Abstractpub_date
2005-06-02 00:00:00pages
731-44issue
5eissn
0896-6273issn
1097-4199pii
S0896-6273(05)00360-0journal_volume
46pub_type
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