Abstract：
:The MAG-deficient mouse was used to test whether MAG acts as a significant inhibitor of axonal regeneration in the adult mammalian CNS, as suggested by cell culture experiments. Cell spreading, neurite elongation, or growth cone collapse of different cell types in vitro was not significantly different when myelin preparations or optic nerve cryosections from either MAG-deficient or wild-type mice were used as a substrate. More importantly, the extent of axonal regrowth in lesioned optic nerve and corticospinal tract in vivo was similarly poor in MAG-deficient and wild-type mice. However, axonal regrowth increased significantly and to a similar extent in both genotypes after application of the IN-1 antibody directed against the neurite growth inhibitors NI-35 and NI-250. These observations do not support the view that MAG is a significant inhibitor of axonal regeneration in the adult CNS.
journal_name
Neuronjournal_title
Neuronauthors
Bartsch U,Bandtlow CE,Schnell L,Bartsch S,Spillmann AA,Rubin BP,Hillenbrand R,Montag D,Schwab ME,Schachner Mdoi
10.1016/0896-6273(95)90015-2subject
Has Abstractpub_date
1995-12-01 00:00:00pages
1375-81issue
6eissn
0896-6273issn
1097-4199pii
0896-6273(95)90015-2journal_volume
15pub_type
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